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Items: 1 to 20 of 117

1.

In vitro and in vivo evaluation of a hydrogel reservoir as a continuous drug delivery system for inner ear treatment.

Hütten M, Dhanasingh A, Hessler R, Stöver T, Esser KH, Möller M, Lenarz T, Jolly C, Groll J, Scheper V.

PLoS One. 2014 Aug 8;9(8):e104564. doi: 10.1371/journal.pone.0104564. eCollection 2014.

2.

A novel controlled local drug delivery system for inner ear disease.

Paulson DP, Abuzeid W, Jiang H, Oe T, O'Malley BW, Li D.

Laryngoscope. 2008 Apr;118(4):706-11. doi: 10.1097/MLG.0b013e31815f8e41.

PMID:
18182968
3.

Effects of intraoperatively applied glucocorticoid hydrogels on residual hearing and foreign body reaction in a guinea pig model of cochlear implantation.

Honeder C, Landegger LD, Engleder E, Gabor F, Plasenzotti R, Plenk H, Kaider A, Hirtler L, Gstoettner W, Arnoldner C.

Acta Otolaryngol. 2015 Apr;135(4):313-9. doi: 10.3109/00016489.2014.986758. Epub 2015 Feb 26.

4.

Distribution of dexamethasone and preservation of inner ear function following intratympanic delivery of a gel-based formulation.

Salt AN, Hartsock J, Plontke S, LeBel C, Piu F.

Audiol Neurootol. 2011;16(5):323-35. doi: 10.1159/000322504. Epub 2010 Dec 19.

5.

Trans-Oval-Window Implants, A New Approach for Drug Delivery to the Inner Ear: Extended Dexamethasone Release From Silicone-based Implants.

Sircoglou J, Gehrke M, Tardivel M, Siepmann F, Siepmann J, Vincent C.

Otol Neurotol. 2015 Sep;36(9):1572-9. doi: 10.1097/MAO.0000000000000855.

PMID:
26375981
6.

Intra-cochlear administration of dexamethasone attenuates aminoglycoside ototoxicity in the guinea pig.

Himeno C, Komeda M, Izumikawa M, Takemura K, Yagi M, Weiping Y, Doi T, Kuriyama H, Miller JM, Yamashita T.

Hear Res. 2002 May;167(1-2):61-70.

PMID:
12117531
7.

Protection of inner ear function after cochlear implantation: compound action potential measurements after local application of glucocorticoids in the guinea pig cochlea.

Braun S, Ye Q, Radeloff A, Kiefer J, Gstoettner W, Tillein J.

ORL J Otorhinolaryngol Relat Spec. 2011;73(4):219-28. doi: 10.1159/000329791. Epub 2011 Jul 21.

PMID:
21778784
8.

Round window delivery of dexamethasone ameliorates local and remote hearing loss produced by cochlear implantation into the second turn of the guinea pig cochlea.

Eastwood H, Chang A, Kel G, Sly D, Richardson R, O'Leary SJ.

Hear Res. 2010 Jun 14;265(1-2):25-9. doi: 10.1016/j.heares.2010.03.006. Epub 2010 Mar 18.

PMID:
20303400
9.

Assessment of PLGA-PEG-PLGA copolymer hydrogel for sustained drug delivery in the ear.

Feng L, Ward JA, Li SK, Tolia G, Hao J, Choo DI.

Curr Drug Deliv. 2014;11(2):279-86.

10.

Targeted therapy of the inner ear.

Maini S, Lisnichuk H, Eastwood H, Pinder D, James D, Richardson RT, Chang A, Connolly T, Sly D, Kel G, O'Leary SJ.

Audiol Neurootol. 2009;14(6):402-10. doi: 10.1159/000241897. Epub 2009 Nov 16.

PMID:
19923810
11.
12.

Inner ear delivery of dexamethasone using injectable silk-polyethylene glycol (PEG) hydrogel.

Yu D, Sun C, Zheng Z, Wang X, Chen D, Wu H, Wang X, Shi F.

Int J Pharm. 2016 Apr 30;503(1-2):229-37. doi: 10.1016/j.ijpharm.2016.02.048. Epub 2016 Mar 10.

PMID:
26972377
13.

Technical note on microcatheter implantation for local inner ear drug delivery: surgical technique and safety aspects.

Plontke SK, Zimmermann R, Zenner HP, Löwenheim H.

Otol Neurotol. 2006 Oct;27(7):912-7.

PMID:
17006340
14.

A novel chitosan-hydrogel-based nanoparticle delivery system for local inner ear application.

Lajud SA, Nagda DA, Qiao P, Tanaka N, Civantos A, Gu R, Cheng Z, Tsourkas A, O'Malley BW Jr, Li D.

Otol Neurotol. 2015 Feb;36(2):341-7. doi: 10.1097/MAO.0000000000000445.

15.

Hydrogel coated and dexamethasone releasing cochlear implants: quantification of fibrosis in guinea pigs and evaluation of insertion forces in a human cochlea model.

Wrzeszcz A, Steffens M, Balster S, Warnecke A, Dittrich B, Lenarz T, Reuter G.

J Biomed Mater Res B Appl Biomater. 2015 Jan;103(1):169-78. doi: 10.1002/jbm.b.33187. Epub 2014 May 8.

PMID:
24811046
16.

Growth factor-eluting cochlear implant electrode: impact on residual auditory function, insertional trauma, and fibrosis.

Kikkawa YS, Nakagawa T, Ying L, Tabata Y, Tsubouchi H, Ido A, Ito J.

J Transl Med. 2014 Oct 4;12:280. doi: 10.1186/s12967-014-0280-4.

17.

Dose-dependent sustained release of dexamethasone in inner ear cochlear fluids using a novel local delivery approach.

Wang X, Dellamary L, Fernandez R, Harrop A, Keithley EM, Harris JP, Ye Q, Lichter J, LeBel C, Piu F.

Audiol Neurootol. 2009;14(6):393-401. doi: 10.1159/000241896. Epub 2009 Nov 16.

PMID:
19923809
18.

Effect of both local and systemically administered dexamethasone on long-term hearing and tissue response in a Guinea pig model of cochlear implantation.

Lee J, Ismail H, Lee JH, Kel G, O'Leary J, Hampson A, Eastwood H, O'Leary SJ.

Audiol Neurootol. 2013;18(6):392-405. doi: 10.1159/000353582. Epub 2013 Nov 1.

PMID:
24192718
19.

Effects of sustained release dexamethasone hydrogels in hearing preservation cochlear implantation.

Honeder C, Zhu C, Schöpper H, Gausterer JC, Walter M, Landegger LD, Saidov N, Riss D, Plasenzotti R, Gabor F, Arnoldner C.

Hear Res. 2016 Aug 9;341:43-49. doi: 10.1016/j.heares.2016.08.001. [Epub ahead of print]

20.

A regulated delivery system for inner ear drug application.

Lajud SA, Han Z, Chi FL, Gu R, Nagda DA, Bezpalko O, Sanyal S, Bur A, Han Z, O'Malley BW Jr, Li D.

J Control Release. 2013 Mar 28;166(3):268-76. doi: 10.1016/j.jconrel.2012.12.031. Epub 2013 Jan 8.

PMID:
23313113
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