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Items: 1 to 20 of 92

1.

Bi-HAC vector system toward gene and cell therapy.

Iida Y, Kazuki Y, Hayashi M, Ueda Y, Hasegawa M, Kouprina N, Larionov V, Oshimura M.

ACS Synth Biol. 2014 Feb 21;3(2):83-90. doi: 10.1021/sb400166j. Epub 2014 Jan 9.

2.

Human artificial chromosome with a conditional centromere for gene delivery and gene expression.

Iida Y, Kim JH, Kazuki Y, Hoshiya H, Takiguchi M, Hayashi M, Erliandri I, Lee HS, Samoshkin A, Masumoto H, Earnshaw WC, Kouprina N, Larionov V, Oshimura M.

DNA Res. 2010 Oct;17(5):293-301. doi: 10.1093/dnares/dsq020. Epub 2010 Aug 26.

3.

Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells.

Kim JH, Kononenko A, Erliandri I, Kim TA, Nakano M, Iida Y, Barrett JC, Oshimura M, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20048-53. doi: 10.1073/pnas.1114483108. Epub 2011 Nov 28.

4.

A method for producing transgenic cells using a multi-integrase system on a human artificial chromosome vector.

Yamaguchi S, Kazuki Y, Nakayama Y, Nanba E, Oshimura M, Ohbayashi T.

PLoS One. 2011 Feb 24;6(2):e17267. doi: 10.1371/journal.pone.0017267.

5.

A novel system for simultaneous or sequential integration of multiple gene-loading vectors into a defined site of a human artificial chromosome.

Suzuki T, Kazuki Y, Oshimura M, Hara T.

PLoS One. 2014 Oct 10;9(10):e110404. doi: 10.1371/journal.pone.0110404. eCollection 2014.

6.

Integration-free and stable expression of FVIII using a human artificial chromosome.

Kurosaki H, Hiratsuka M, Imaoka N, Iida Y, Uno N, Kazuki Y, Ishihara C, Yakura Y, Mimuro J, Sakata Y, Takeya H, Oshimura M.

J Hum Genet. 2011 Oct;56(10):727-33. doi: 10.1038/jhg.2011.88. Epub 2011 Aug 11.

PMID:
21833006
7.

Construction of a novel human artificial chromosome vector for gene delivery.

Katoh M, Ayabe F, Norikane S, Okada T, Masumoto H, Horike S, Shirayoshi Y, Oshimura M.

Biochem Biophys Res Commun. 2004 Aug 20;321(2):280-90.

PMID:
15358173
8.

Protecting a transgene expression from the HAC-based vector by different chromatin insulators.

Lee NC, Kononenko AV, Lee HS, Tolkunova EN, Liskovykh MA, Masumoto H, Earnshaw WC, Tomilin AN, Larionov V, Kouprina N.

Cell Mol Life Sci. 2013 Oct;70(19):3723-37. doi: 10.1007/s00018-013-1362-9. Epub 2013 May 16.

9.

Integration-free iPS cells engineered using human artificial chromosome vectors.

Hiratsuka M, Uno N, Ueda K, Kurosaki H, Imaoka N, Kazuki K, Ueno E, Akakura Y, Katoh M, Osaki M, Kazuki Y, Nakagawa M, Yamanaka S, Oshimura M.

PLoS One. 2011;6(10):e25961. doi: 10.1371/journal.pone.0025961. Epub 2011 Oct 5.

10.

Telomerase-mediated life-span extension of human primary fibroblasts by human artificial chromosome (HAC) vector.

Shitara S, Kakeda M, Nagata K, Hiratsuka M, Sano A, Osawa K, Okazaki A, Katoh M, Kazuki Y, Oshimura M, Tomizuka K.

Biochem Biophys Res Commun. 2008 May 9;369(3):807-11. doi: 10.1016/j.bbrc.2008.02.119. Epub 2008 Mar 5.

PMID:
18328257
11.

A gene delivery system with a human artificial chromosome vector based on migration of mesenchymal stem cells towards human glioblastoma HTB14 cells.

Kinoshita Y, Kamitani H, Mamun MH, Wasita B, Kazuki Y, Hiratsuka M, Oshimura M, Watanabe T.

Neurol Res. 2010 May;32(4):429-37. doi: 10.1179/174313209X455718. Epub 2009 Jul 8.

PMID:
19589205
12.

Introduction of a CD40L genomic fragment via a human artificial chromosome vector permits cell-type-specific gene expression and induces immunoglobulin secretion.

Yamada H, Li YC, Nishikawa M, Oshimura M, Inoue T.

J Hum Genet. 2008;53(5):447-53. doi: 10.1007/s10038-008-0268-0. Epub 2008 Mar 6.

PMID:
18322642
13.

Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette.

Kononenko AV, Lee NC, Liskovykh M, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.

Nucleic Acids Res. 2015 May 19;43(9):e57. doi: 10.1093/nar/gkv124. Epub 2015 Feb 20.

14.

A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells.

Kakeda M, Nagata K, Osawa K, Matsuno H, Hiratsuka M, Sano A, Okazaki A, Shitara S, Nishikawa S, Masuya A, Hata T, Wako S, Osaki M, Kazuki Y, Oshimura M, Tomizuka K.

Biochem Biophys Res Commun. 2011 Nov 25;415(3):439-44. doi: 10.1016/j.bbrc.2011.10.088. Epub 2011 Oct 22.

PMID:
22051050
15.

Efficient assembly of de novo human artificial chromosomes from large genomic loci.

Basu J, Compitello G, Stromberg G, Willard HF, Van Bokkelen G.

BMC Biotechnol. 2005 Jul 5;5:21.

16.

Refined human artificial chromosome vectors for gene therapy and animal transgenesis.

Kazuki Y, Hoshiya H, Takiguchi M, Abe S, Iida Y, Osaki M, Katoh M, Hiratsuka M, Shirayoshi Y, Hiramatsu K, Ueno E, Kajitani N, Yoshino T, Kazuki K, Ishihara C, Takehara S, Tsuji S, Ejima F, Toyoda A, Sakaki Y, Larionov V, Kouprina N, Oshimura M.

Gene Ther. 2011 Apr;18(4):384-93. doi: 10.1038/gt.2010.147. Epub 2010 Nov 18.

17.

A novel human artificial chromosome vector provides effective cell lineage-specific transgene expression in human mesenchymal stem cells.

Ren X, Katoh M, Hoshiya H, Kurimasa A, Inoue T, Ayabe F, Shibata K, Toguchida J, Oshimura M.

Stem Cells. 2005 Nov-Dec;23(10):1608-16. Epub 2005 Sep 1.

18.

Retargeting of microcell fusion towards recipient cell-oriented transfer of human artificial chromosome.

Hiratsuka M, Ueda K, Uno N, Uno K, Fukuhara S, Kurosaki H, Takehara S, Osaki M, Kazuki Y, Kurosawa Y, Nakamura T, Katoh M, Oshimura M.

BMC Biotechnol. 2015 Jun 19;15:58. doi: 10.1186/s12896-015-0142-z.

19.

Organization of synthetic alphoid DNA array in human artificial chromosome (HAC) with a conditional centromere.

Kouprina N, Samoshkin A, Erliandri I, Nakano M, Lee HS, Fu H, Iida Y, Aladjem M, Oshimura M, Masumoto H, Earnshaw WC, Larionov V.

ACS Synth Biol. 2012 Dec 21;1(12):590-601.

20.

A novel expression system for genomic DNA loci using a human artificial chromosome vector with transformation-associated recombination cloning.

Ayabe F, Katoh M, Inoue T, Kouprina N, Larionov V, Oshimura M.

J Hum Genet. 2005;50(11):592-9. Epub 2005 Oct 18.

PMID:
16231070

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