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Items: 1 to 20 of 87


Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival.

Wang WH, Childress MO, Geahlen RL.

Mol Cell Biol. 2014 Oct;34(20):3788-99. doi: 10.1128/MCB.00937-14. Epub 2014 Aug 4.


Nucleolin stabilizes Bcl-X L messenger RNA in response to UVA irradiation.

Zhang J, Tsaprailis G, Bowden GT.

Cancer Res. 2008 Feb 15;68(4):1046-54. doi: 10.1158/0008-5472.CAN-07-1927.


The nucleolin targeting aptamer AS1411 destabilizes Bcl-2 messenger RNA in human breast cancer cells.

Soundararajan S, Chen W, Spicer EK, Courtenay-Luck N, Fernandes DJ.

Cancer Res. 2008 Apr 1;68(7):2358-65. doi: 10.1158/0008-5472.CAN-07-5723.


Modulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells.

Fei B, Yu S, Geahlen RL.

Biochim Biophys Acta. 2013 Oct;1833(10):2153-64. doi: 10.1016/j.bbamcr.2013.05.010. Epub 2013 May 16.


A novel post-translational modification of nucleolin, SUMOylation at Lys-294, mediates arsenite-induced cell death by regulating gadd45α mRNA stability.

Zhang D, Liang Y, Xie Q, Gao G, Wei J, Huang H, Li J, Gao J, Huang C.

J Biol Chem. 2015 Feb 20;290(8):4784-800. doi: 10.1074/jbc.M114.598219. Epub 2015 Jan 5.


Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cells.

Lee YH, Mungunsukh O, Tutino RL, Marquez AP, Day RM.

J Cell Sci. 2010 May 15;123(Pt 10):1634-43. doi: 10.1242/jcs.063545. Epub 2010 Apr 20.


The importance of Bcl-xL in the survival of human RPE cells.

Zhang N, Peairs JJ, Yang P, Tyrrell J, Roberts J, Kole R, Jaffe GJ.

Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3846-53.


Syk is required for the activation of Akt survival pathway in B cells exposed to oxidative stress.

Ding J, Takano T, Gao S, Han W, Noda C, Yanagi S, Yamamura H.

J Biol Chem. 2000 Oct 6;275(40):30873-7.


Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.

Krisenko MO, Geahlen RL.

Biochim Biophys Acta. 2015 Jan;1853(1):254-63. doi: 10.1016/j.bbamcr.2014.10.022. Epub 2014 Nov 4. Review.


Syk is required for p38 activation and G2/M arrest in B cells exposed to oxidative stress.

He J, Takano T, Ding J, Gao S, Noda C, Sada K, Yanagi S, Yamamura H.

Antioxid Redox Signal. 2002 Jun;4(3):509-15.


Nucleolin/C23 is a negative regulator of hydrogen peroxide-induced apoptosis in HUVECs.

Zhang B, Wang H, Jiang B, Liang P, Liu M, Deng G, Xiao X.

Cell Stress Chaperones. 2010 May;15(3):249-57. doi: 10.1007/s12192-009-0138-5. Epub 2009 Sep 13.


Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth.

Gururajan M, Dasu T, Shahidain S, Jennings CD, Robertson DA, Rangnekar VM, Bondada S.

J Immunol. 2007 Jan 1;178(1):111-21.


Suppression of apoptosis and granulocyte colony-stimulating factor-induced differentiation by an oncogenic form of Cbl.

Sinha S, Jancarik J, Roginskaya V, Rothermund K, Boxer LM, Corey SJ.

Exp Hematol. 2001 Jun;29(6):746-55.


C-reactive protein suppresses insulin signaling in endothelial cells: role of spleen tyrosine kinase.

Xu JW, Morita I, Ikeda K, Miki T, Yamori Y.

Mol Endocrinol. 2007 Feb;21(2):564-73. Epub 2006 Nov 9.


Regulation of Bcl-2 expression by HuR in HL60 leukemia cells and A431 carcinoma cells.

Ishimaru D, Ramalingam S, Sengupta TK, Bandyopadhyay S, Dellis S, Tholanikunnel BG, Fernandes DJ, Spicer EK.

Mol Cancer Res. 2009 Aug;7(8):1354-66. doi: 10.1158/1541-7786.MCR-08-0476. Epub 2009 Aug 11.


The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x.

Paronetto MP, Achsel T, Massiello A, Chalfant CE, Sette C.

J Cell Biol. 2007 Mar 26;176(7):929-39. Epub 2007 Mar 19.


Overexpression of nucleolin in chronic lymphocytic leukemia cells induces stabilization of bcl2 mRNA.

Otake Y, Soundararajan S, Sengupta TK, Kio EA, Smith JC, Pineda-Roman M, Stuart RK, Spicer EK, Fernandes DJ.

Blood. 2007 Apr 1;109(7):3069-75.


The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression.

Baudot AD, Jeandel PY, Mouska X, Maurer U, Tartare-Deckert S, Raynaud SD, Cassuto JP, Ticchioni M, Deckert M.

Oncogene. 2009 Sep 17;28(37):3261-73. doi: 10.1038/onc.2009.179. Epub 2009 Jul 6.


B cell responses to oxidative stress.

Tohyama Y, Takano T, Yamamura H.

Curr Pharm Des. 2004;10(8):835-9. Review.


The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells.

Zhou Q, Geahlen RL.

Oncogene. 2009 Mar 12;28(10):1348-56. doi: 10.1038/onc.2008.493. Epub 2009 Jan 19.

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