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Items: 1 to 20 of 108

1.

Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor.

Sivanandhan G, Selvaraj N, Ganapathi A, Manickavasagam M.

PLoS One. 2014 Aug 4;9(8):e104005. doi: 10.1371/journal.pone.0104005. eCollection 2014 Aug 4.

2.

A promising approach on biomass accumulation and withanolides production in cell suspension culture of Withania somnifera (L.) Dunal.

Sivanandhan G, Kapil Dev G, Jeyaraj M, Rajesh M, Muthuselvam M, Selvaraj N, Manickavasagam M, Ganapathi A.

Protoplasma. 2013 Aug;250(4):885-98. doi: 10.1007/s00709-012-0471-x. Epub 2012 Dec 18.

PMID:
23247920
3.

Optimization of elicitation conditions with methyl jasmonate and salicylic acid to improve the productivity of withanolides in the adventitious root culture of Withania somnifera (L.) Dunal.

Sivanandhan G, Arun M, Mayavan S, Rajesh M, Jeyaraj M, Dev GK, Manickavasagam M, Selvaraj N, Ganapathi A.

Appl Biochem Biotechnol. 2012 Oct;168(3):681-96. doi: 10.1007/s12010-012-9809-2. Epub 2012 Jul 28.

PMID:
22843063
4.

Withanolide biosynthesis recruits both mevalonate and DOXP pathways of isoprenogenesis in Ashwagandha Withania somnifera L. (Dunal).

Chaurasiya ND, Sangwan NS, Sabir F, Misra L, Sangwan RS.

Plant Cell Rep. 2012 Oct;31(10):1889-97. doi: 10.1007/s00299-012-1302-4. Epub 2012 Jun 26.

PMID:
22733207
5.

Comparative study of withanolide production and the related transcriptional responses of biosynthetic genes in fungi elicited cell suspension culture of Withania somnifera in shake flask and bioreactor.

Ahlawat S, Saxena P, Ali A, Khan S, Abdin MZ.

Plant Physiol Biochem. 2017 May;114:19-28. doi: 10.1016/j.plaphy.2017.02.013. Epub 2017 Feb 17.

PMID:
28249222
6.

Elicitation Approaches for Withanolide Production in Hairy Root Culture of Withania somnifera (L.) Dunal.

Sivanandhan G, Selvaraj N, Ganapathi A, Manickavasagam M.

Methods Mol Biol. 2016;1405:1-18. doi: 10.1007/978-1-4939-3393-8_1.

PMID:
26843160
7.

Effect of carbon and nitrogen sources on in vitro flower and fruit formation and withanolides production in Withania somnifera (L.) Dunal.

Sivanandhan G, Theboral J, Dev GK, Selvaraj N, Manickavasagam M, Ganapathi A.

Indian J Exp Biol. 2015 Mar;53(3):177-83.

PMID:
25872249
8.

Dynamics of withanolide biosynthesis in relation to temporal expression pattern of metabolic genes in Withania somnifera (L.) Dunal: a comparative study in two morpho-chemovariants.

Dhar N, Rana S, Bhat WW, Razdan S, Pandith SA, Khan S, Dutt P, Dhar RS, Vaishnavi S, Vishwakarma R, Lattoo SK.

Mol Biol Rep. 2013 Dec;40(12):7007-16. doi: 10.1007/s11033-013-2820-z. Epub 2013 Nov 5.

PMID:
24190485
9.

Enhanced withanolide production by overexpression of squalene synthase in Withania somnifera.

Grover A, Samuel G, Bisaria VS, Sundar D.

J Biosci Bioeng. 2013 Jun;115(6):680-5. doi: 10.1016/j.jbiosc.2012.12.011. Epub 2013 Jan 10.

PMID:
23313565
10.

Carbon sources and medium pH affects the growth of Withania somnifera (L.) Dunal adventitious roots and withanolide A production.

Murthy HN, Praveen N.

Nat Prod Res. 2013;27(2):185-9. doi: 10.1080/14786419.2012.660691. Epub 2012 Mar 7.

PMID:
22394118
11.

Optimization of carbon source for hairy root growth and withaferin A and withanone production in Withania somnifera.

Sivanandhan G, Rajesh M, Arun M, Jeyaraj M, Dev GK, Manickavasagam M, Selvaraj N, Ganapathi A.

Nat Prod Commun. 2012 Oct;7(10):1271-2.

PMID:
23156987
12.

Expression of important pathway genes involved in withanolides biosynthesis in hairy root culture of Withania somnifera upon treatment with Gracilaria edulis and Sargassum wightii.

Sivanandhan G, Arunachalam C, Selvaraj N, Sulaiman AA, Lim YP, Ganapathi A.

Plant Physiol Biochem. 2015 Jun;91:61-4. doi: 10.1016/j.plaphy.2015.04.007. Epub 2015 Apr 11.

PMID:
25885356
13.

Qualitative and quantitative variations in withanolides and expression of some pathway genes during different stages of morphogenesis in Withania somnifera Dunal.

Sabir F, Mishra S, Sangwan RS, Jadaun JS, Sangwan NS.

Protoplasma. 2013 Apr;250(2):539-49. doi: 10.1007/s00709-012-0438-y. Epub 2012 Aug 10.

PMID:
22878597
14.

Influence of macro elements and nitrogen source on adventitious root growth and withanolide-A production in Withania somnifera (L.) Dunal.

Murthy HN, Praveen N.

Nat Prod Res. 2012;26(5):466-73. doi: 10.1080/14786419.2010.490914. Epub 2011 Jun 3.

PMID:
21644171
15.

Virus-induced gene silencing of Withania somnifera squalene synthase negatively regulates sterol and defence-related genes resulting in reduced withanolides and biotic stress tolerance.

Singh AK, Dwivedi V, Rai A, Pal S, Reddy SG, Rao DK, Shasany AK, Nagegowda DA.

Plant Biotechnol J. 2015 Dec;13(9):1287-99. doi: 10.1111/pbi.12347. Epub 2015 Mar 24.

16.
17.

Withanolides from Withania somnifera Dunal: development of cellular technology and their production.

Sangwan NS, Sabir F, Mishra S, Bansal S, Sangwan RS.

Recent Pat Biotechnol. 2014;8(1):25-35.

PMID:
24354530
18.

Sterol partitioning by HMGR and DXR for routing intermediates toward withanolide biosynthesis.

Singh S, Pal S, Shanker K, Chanotiya CS, Gupta MM, Dwivedi UN, Shasany AK.

Physiol Plant. 2014 Dec;152(4):617-33. doi: 10.1111/ppl.12213. Epub 2014 Jun 3.

PMID:
24749735
19.

Dual elicitation for improved production of withaferin A by cell suspension cultures of Withania somnifera.

Baldi A, Singh D, Dixit VK.

Appl Biochem Biotechnol. 2008 Dec;151(2-3):556-64. doi: 10.1007/s12010-008-8231-2. Epub 2008 May 1.

PMID:
18449479
20.

Metabolic clustering of a core collection of Indian ginseng Withania somnifera Dunal through DNA, isoenzyme, polypeptide and withanolide profile diversity.

Chaurasiya ND, Sangwan RS, Misra LN, Tuli R, Sangwan NS.

Fitoterapia. 2009 Dec;80(8):496-505. doi: 10.1016/j.fitote.2009.06.012. Epub 2009 Jun 24.

PMID:
19559768

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