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Items: 1 to 20 of 68


The effect of chicken extract on ERK/CREB signaling is ApoE isoform-dependent.

Yong SM, Ong QR, Siew BE, Wong BS.

Food Funct. 2014 Sep;5(9):2043-51. doi: 10.1039/c4fo00428k.


Reduced neuronal signaling in the ageing apolipoprotein-E4 targeted replacement female mice.

Yong SM, Lim ML, Low CM, Wong BS.

Sci Rep. 2014 Oct 10;4:6580. doi: 10.1038/srep06580.


Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway.

Ohkubo N, Mitsuda N, Tamatani M, Yamaguchi A, Lee YD, Ogihara T, Vitek MP, Tohyama M.

J Biol Chem. 2001 Feb 2;276(5):3046-53. Epub 2000 Oct 20.


APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice.

Liu DS, Pan XD, Zhang J, Shen H, Collins NC, Cole AM, Koster KP, Ben Aissa M, Dai XM, Zhou M, Tai LM, Zhu YG, LaDu M, Chen XC.

Mol Neurodegener. 2015 Mar 5;10:7. doi: 10.1186/s13024-015-0002-2.


Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model.

Nishitsuji K, Hosono T, Nakamura T, Bu G, Michikawa M.

J Biol Chem. 2011 May 20;286(20):17536-42. doi: 10.1074/jbc.M111.225532. Epub 2011 Apr 6.


Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y.

J Neurosci. 2004 Mar 10;24(10):2527-34.


Androgen-mediated immune function is altered by the apolipoprotein E gene.

Brown CM, Xu Q, Okhubo N, Vitek MP, Colton CA.

Endocrinology. 2007 Jul;148(7):3383-90. Epub 2007 Mar 29.


Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture.

Minagawa H, Gong JS, Jung CG, Watanabe A, Lund-Katz S, Phillips MC, Saito H, Michikawa M.

J Neurosci Res. 2009 Aug 15;87(11):2498-508. doi: 10.1002/jnr.22073.


Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels.

Li H, Dhanasekaran P, Alexander ET, Rader DJ, Phillips MC, Lund-Katz S.

Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):687-93. doi: 10.1161/ATVBAHA.112.301193. Epub 2013 Feb 14.


Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration.

Edwards S, Graham DL, Bachtell RK, Self DW.

Eur J Neurosci. 2007 Apr;25(7):2201-13.


Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice.

Bien-Ly N, Gillespie AK, Walker D, Yoon SY, Huang Y.

J Neurosci. 2012 Apr 4;32(14):4803-11. doi: 10.1523/JNEUROSCI.0033-12.2012.


4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.

Al Rahim M, Nakajima A, Saigusa D, Tetsu N, Maruyama Y, Shibuya M, Yamakoshi H, Tomioka Y, Iwabuchi Y, Ohizumi Y, Yamakuni T.

Biochemistry. 2009 Aug 18;48(32):7713-21. doi: 10.1021/bi901088w.


Altered cerebral insulin response in transgenic mice expressing the epsilon-4 allele of the human apolipoprotein E gene.

Traversy MT, Vandal M, Tremblay C, Tournissac M, Giguère-Rancourt A, Bennett AD, Calon F.

Psychoneuroendocrinology. 2017 Mar;77:203-210. doi: 10.1016/j.psyneuen.2016.11.028. Epub 2016 Nov 30.


apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain.

Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV.

J Clin Invest. 2008 Dec;118(12):4002-13. doi: 10.1172/JCI36663. Epub 2008 Nov 13.


The effects of apolipoproteins E3 and E4 on the transforming growth factor-β system in targeted replacement mice.

Haas A, Liraz O, Michaelson DM.

Neurodegener Dis. 2012;10(1-4):41-5. doi: 10.1159/000334902. Epub 2012 Feb 1.


Polygalasaponin F induces long-term potentiation in adult rat hippocampus via NMDA receptor activation.

Sun F, Sun JD, Han N, Li CJ, Yuan YH, Zhang DM, Chen NH.

Acta Pharmacol Sin. 2012 Apr;33(4):431-7. doi: 10.1038/aps.2011.199. Epub 2012 Jan 30.


Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice.

Gong JS, Kobayashi M, Hayashi H, Zou K, Sawamura N, Fujita SC, Yanagisawa K, Michikawa M.

J Biol Chem. 2002 Aug 16;277(33):29919-26. Epub 2002 May 31.

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