Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 99

1.

Deep mutational scanning: a new style of protein science.

Fowler DM, Fields S.

Nat Methods. 2014 Aug;11(8):801-7. doi: 10.1038/nmeth.3027.

2.

Rational Protein Engineering Guided by Deep Mutational Scanning.

Shin H, Cho BK.

Int J Mol Sci. 2015 Sep 23;16(9):23094-110. doi: 10.3390/ijms160923094. Review.

3.

Deep mutational scanning: assessing protein function on a massive scale.

Araya CL, Fowler DM.

Trends Biotechnol. 2011 Sep;29(9):435-42. doi: 10.1016/j.tibtech.2011.04.003. Epub 2011 May 10. Review.

4.

Measuring the activity of protein variants on a large scale using deep mutational scanning.

Fowler DM, Stephany JJ, Fields S.

Nat Protoc. 2014 Sep;9(9):2267-84. doi: 10.1038/nprot.2014.153. Epub 2014 Aug 28.

5.

Deep Mutational Scanning: A Highly Parallel Method to Measure the Effects of Mutation on Protein Function.

Starita LM, Fields S.

Cold Spring Harb Protoc. 2015 Aug 3;2015(8):711-4. doi: 10.1101/pdb.top077503.

PMID:
26240414
6.

Natural selection for kinetic stability is a likely origin of correlations between mutational effects on protein energetics and frequencies of amino acid occurrences in sequence alignments.

Godoy-Ruiz R, Ariza F, Rodriguez-Larrea D, Perez-Jimenez R, Ibarra-Molero B, Sanchez-Ruiz JM.

J Mol Biol. 2006 Oct 6;362(5):966-78. Epub 2006 Jul 31.

PMID:
16935299
7.

Enrich: software for analysis of protein function by enrichment and depletion of variants.

Fowler DM, Araya CL, Gerard W, Fields S.

Bioinformatics. 2011 Dec 15;27(24):3430-1. doi: 10.1093/bioinformatics/btr577. Epub 2011 Oct 17.

8.

Automated use of mutagenesis data in structure prediction.

Nanda V, DeGrado WF.

Proteins. 2005 May 15;59(3):454-66.

PMID:
15768404
9.

Lethal mutagenesis in viruses and bacteria.

Chen P, Shakhnovich EI.

Genetics. 2009 Oct;183(2):639-50. doi: 10.1534/genetics.109.106492. Epub 2009 Jul 20.

10.
11.

Additivity of mutational effects in proteins.

Wells JA.

Biochemistry. 1990 Sep 18;29(37):8509-17. No abstract available.

PMID:
2271534
12.

Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences.

Hocking LJ, Lucas GJ, Daroszewska A, Cundy T, Nicholson GC, Donath J, Walsh JP, Finlayson C, Cavey JR, Ciani B, Sheppard PW, Searle MS, Layfield R, Ralston SH.

J Bone Miner Res. 2004 Jul;19(7):1122-7. Epub 2004 Mar 22.

13.

Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2) gene.

Tu N, Chen H, Winnikes U, Reinert I, Marmann G, Pirke KM, Lentes KU.

Life Sci. 1999;64(3):PL41-50.

PMID:
10027754
14.

Untangling the effects of codon mutation and amino acid exchangeability.

Yampolsky LY, Stoltzfus A.

Pac Symp Biocomput. 2005:433-44.

15.

Evolvability and single-genotype fluctuation in phenotypic properties: a simple heteropolymer model.

Chen T, Vernazobres D, Yomo T, Bornberg-Bauer E, Chan HS.

Biophys J. 2010 Jun 2;98(11):2487-96. doi: 10.1016/j.bpj.2010.02.046.

16.

Modelling neutral and selective evolution of protein folding.

Lipman DJ, Wilbur WJ.

Proc Biol Sci. 1991 Jul 22;245(1312):7-11.

PMID:
1682931
17.

The role of functional data in interpreting the effects of genetic variation.

Young DL, Fields S.

Mol Biol Cell. 2015 Nov 5;26(22):3904-8. doi: 10.1091/mbc.E15-03-0153.

18.

Combining natural sequence variation with high throughput mutational data to reveal protein interaction sites.

Melamed D, Young DL, Miller CR, Fields S.

PLoS Genet. 2015 Feb 11;11(2):e1004918. doi: 10.1371/journal.pgen.1004918. eCollection 2015 Feb.

19.

Screening and selection methods for large-scale analysis of protein function.

Lin H, Cornish VW.

Angew Chem Int Ed Engl. 2002 Dec 2;41(23):4402-25. Review.

PMID:
12458502
20.

Advances in directed protein evolution by recursive genetic recombination: applications to therapeutic proteins.

Kurtzman AL, Govindarajan S, Vahle K, Jones JT, Heinrichs V, Patten PA.

Curr Opin Biotechnol. 2001 Aug;12(4):361-70. Review.

PMID:
11551464

Supplemental Content

Support Center