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Items: 1 to 20 of 99

1.

The dynamics of p53 in single cells: physiologically based ODE and reaction-diffusion PDE models.

Eliaš J, Dimitrio L, Clairambault J, Natalini R.

Phys Biol. 2014 Aug;11(4):045001. doi: 10.1088/1478-3975/11/4/045001. Epub 2014 Jul 30.

PMID:
25075792
2.

The Wip1 phosphatase and Mdm2: cracking the "Wip" on p53 stability.

Lu X, Nguyen TA, Zhang X, Donehower LA.

Cell Cycle. 2008 Jan 15;7(2):164-8.

PMID:
18333294
3.

DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase.

Brazina J, Svadlenka J, Macurek L, Andera L, Hodny Z, Bartek J, Hanzlikova H.

Cell Cycle. 2015;14(3):375-87. doi: 10.4161/15384101.2014.988019.

4.

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.

Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA.

Cancer Cell. 2007 Oct;12(4):342-54.

5.

Explaining oscillations and variability in the p53-Mdm2 system.

Proctor CJ, Gray DA.

BMC Syst Biol. 2008 Aug 18;2:75. doi: 10.1186/1752-0509-2-75.

6.

Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.

Batchelor E, Mock CS, Bhan I, Loewer A, Lahav G.

Mol Cell. 2008 May 9;30(3):277-89. doi: 10.1016/j.molcel.2008.03.016.

7.

A theoretical model for p53 dynamics: identifying optimal therapeutic strategy for its activation and stabilization.

Kim DH, Rho K, Kim S.

Cell Cycle. 2009 Nov 15;8(22):3707-16. Epub 2009 Nov 8.

PMID:
19844169
8.

Steady states and oscillations in the p53/Mdm2 network.

Ciliberto A, Novak B, Tyson JJ.

Cell Cycle. 2005 Mar;4(3):488-93. Epub 2005 Mar 18.

PMID:
15725723
9.

p53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback.

Wagner J, Ma L, Rice JJ, Hu W, Levine AJ, Stolovitzky GA.

Syst Biol (Stevenage). 2005 Sep;152(3):109-18.

PMID:
16986275
10.

Attractor landscape analysis reveals feedback loops in the p53 network that control the cellular response to DNA damage.

Choi M, Shi J, Jung SH, Chen X, Cho KH.

Sci Signal. 2012 Nov 20;5(251):ra83. doi: 10.1126/scisignal.2003363.

PMID:
23169817
11.

Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response.

Zhang X, Lin L, Guo H, Yang J, Jones SN, Jochemsen A, Lu X.

Cancer Res. 2009 Oct 15;69(20):7960-8. doi: 10.1158/0008-5472.CAN-09-0634. Epub 2009 Oct 6.

12.

Homeostatic regulation of base excision repair by a p53-induced phosphatase: linking stress response pathways with DNA repair proteins.

Lu X, Nguyen TA, Appella E, Donehower LA.

Cell Cycle. 2004 Nov;3(11):1363-6. Epub 2004 Nov 15.

PMID:
15539943
13.

Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis.

Ma X, Han J, Wu Q, Liu H, Shi S, Wang C, Wang Y, Xiao J, Zhao J, Jiang J, Wan C.

Toxicol Lett. 2015 May 19;235(1):17-27. doi: 10.1016/j.toxlet.2014.12.019. Epub 2015 Mar 16.

PMID:
25791630
14.

Mechanisms that enhance sustainability of p53 pulses.

Kim JK, Jackson TL.

PLoS One. 2013 Jun 3;8(6):e65242. doi: 10.1371/journal.pone.0065242. Print 2013.

15.

MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress.

Biderman L, Poyurovsky MV, Assia Y, Manley JL, Prives C.

Mol Cell Biol. 2012 Apr;32(7):1214-25. doi: 10.1128/MCB.06150-11. Epub 2012 Jan 30.

16.

Oscillations by the p53-Mdm2 feedback loop.

Lahav G.

Adv Exp Med Biol. 2008;641:28-38. Review.

PMID:
18783169
17.

ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation.

Meulmeester E, Pereg Y, Shiloh Y, Jochemsen AG.

Cell Cycle. 2005 Sep;4(9):1166-70. Epub 2005 Sep 29. Review.

PMID:
16082221
18.

Novel recurrent neural network for modelling biological networks: oscillatory p53 interaction dynamics.

Ling H, Samarasinghe S, Kulasiri D.

Biosystems. 2013 Dec;114(3):191-205. doi: 10.1016/j.biosystems.2013.08.004. Epub 2013 Sep 5.

PMID:
24012741
19.

Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.

Shreeram S, Hee WK, Demidov ON, Kek C, Yamaguchi H, Fornace AJ Jr, Anderson CW, Appella E, Bulavin DV.

J Exp Med. 2006 Dec 25;203(13):2793-9. Epub 2006 Dec 11.

20.

Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase.

Yoda A, Toyoshima K, Watanabe Y, Onishi N, Hazaka Y, Tsukuda Y, Tsukada J, Kondo T, Tanaka Y, Minami Y.

J Biol Chem. 2008 Jul 4;283(27):18969-79. doi: 10.1074/jbc.M800560200. Epub 2008 May 15.

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