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Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy.

Gangadhariah MH, Luther JM, Garcia V, Paueksakon P, Zhang MZ, Hayward SW, Love HD, Falck JR, Manthati VL, Imig JD, Schwartzman ML, Zent R, Capdevila JH, Pozzi A.

J Am Soc Nephrol. 2015 Mar;26(3):597-610. doi: 10.1681/ASN.2013090980. Epub 2014 Jul 28.


Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.

Wu CC, Mei S, Cheng J, Ding Y, Weidenhammer A, Garcia V, Zhang F, Gotlinger K, Manthati VL, Falck JR, Capdevila JH, Schwartzman ML.

J Am Soc Nephrol. 2013 Jul;24(8):1288-96. doi: 10.1681/ASN.2012070714. Epub 2013 May 2.


20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.

Ding Y, Wu CC, Garcia V, Dimitrova I, Weidenhammer A, Joseph G, Zhang F, Manthati VL, Falck JR, Capdevila JH, Schwartzman ML.

Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F753-63. doi: 10.1152/ajprenal.00292.2013. Epub 2013 Jul 3.


Lymphocytes promote albuminuria, but not renal dysfunction or histological damage in a mouse model of diabetic renal injury.

Lim AK, Ma FY, Nikolic-Paterson DJ, Kitching AR, Thomas MC, Tesch GH.

Diabetologia. 2010 Aug;53(8):1772-82. doi: 10.1007/s00125-010-1757-1. Epub 2010 Apr 27.


Involvement of renal cytochromes P450 and arachidonic acid metabolites in diabetic nephropathy.

Eid S, Abou-Kheir W, Sabra R, Daoud G, Jaffa A, Ziyadeh FN, Roman L, Eid AA.

J Biol Regul Homeost Agents. 2013 Jul-Sep;27(3):693-703.


Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis.

Herbach N, Schairer I, Blutke A, Kautz S, Siebert A, Göke B, Wolf E, Wanke R.

Am J Physiol Renal Physiol. 2009 Apr;296(4):F819-29. doi: 10.1152/ajprenal.90665.2008. Epub 2009 Feb 11.


Renal vascular cytochrome P450-derived eicosanoids in androgen-induced hypertension.

Singh H, Schwartzman ML.

Pharmacol Rep. 2008 Jan-Feb;60(1):29-37.


Cytochrome P450 eicosanoids in hypertension and renal disease.

Fan F, Muroya Y, Roman RJ.

Curr Opin Nephrol Hypertens. 2015 Jan;24(1):37-46. doi: 10.1097/MNH.0000000000000088. Review.


Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: possible predictive marker for incipient diabetic nephropathy.

Thomson SE, McLennan SV, Kirwan PD, Heffernan SJ, Hennessy A, Yue DK, Twigg SM.

J Diabetes Complications. 2008 Jul-Aug;22(4):284-94. doi: 10.1016/j.jdiacomp.2007.07.001. Epub 2008 Apr 16.


Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.

Fidelis P, Wilson L, Thomas K, Villalobos M, Oyekan AO.

Exp Biol Med (Maywood). 2010 Nov;235(11):1365-74. doi: 10.1258/ebm.2010.009233. Epub 2010 Oct 13.


p27(Kip1) Knockout mice are protected from diabetic nephropathy: evidence for p27(Kip1) haplotype insufficiency.

Wolf G, Schanze A, Stahl RA, Shankland SJ, Amann K.

Kidney Int. 2005 Oct;68(4):1583-9.


PTGER1 deletion attenuates renal injury in diabetic mouse models.

Thibodeau JF, Nasrallah R, Carter A, He Y, Touyz R, Hébert RL, Kennedy CRJ.

Am J Pathol. 2013 Dec;183(6):1789-1802. doi: 10.1016/j.ajpath.2013.08.022. Epub 2013 Oct 8.


20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway.

Eid S, Maalouf R, Jaffa AA, Nassif J, Hamdy A, Rashid A, Ziyadeh FN, Eid AA.

PLoS One. 2013 Aug 2;8(8):e70029. doi: 10.1371/journal.pone.0070029. Print 2013.


The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.

Pandey V, Garcia V, Gilani A, Mishra P, Zhang FF, Paudyal MP, Falck JR, Nasjletti A, Wang WH, Schwartzman ML.

J Pharmacol Exp Ther. 2017 Dec;363(3):412-418. doi: 10.1124/jpet.117.243618. Epub 2017 Sep 14.


Disturbed ratio of renal 20-HETE/EETs is involved in androgen-induced hypertension in cytochrome P450 4F2 transgenic mice.

Liu X, Wu J, Liu H, Lai G, Zhao Y.

Gene. 2012 Sep 1;505(2):352-9. doi: 10.1016/j.gene.2012.02.029. Epub 2012 Feb 24.


Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure.

Liu X, Zhao Y, Wang L, Yang X, Zheng Z, Zhang Y, Chen F, Liu H.

Kidney Int. 2009 Jun;75(12):1288-96. doi: 10.1038/ki.2009.67. Epub 2009 Mar 11.


[Slowing the progression of chronic renal insufficiency with captopril in rats with spontaneous arterial hypertension and adriamycin nephropathy].

Jovanović DB, Jovović Dj, Varagić J, Dimitrijević J, Dragojlović Z, Djukanović L.

Srp Arh Celok Lek. 2002 Mar-Apr;130(3-4):73-80. Serbian.


Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT1 receptor antagonist.

Zhang Y, Deb DK, Kong J, Ning G, Wang Y, Li G, Chen Y, Zhang Z, Strugnell S, Sabbagh Y, Arbeeny C, Li YC.

Am J Physiol Renal Physiol. 2009 Sep;297(3):F791-801. doi: 10.1152/ajprenal.00247.2009. Epub 2009 Jun 17.


Control of glomerular hyperfiltration and renal hypertrophy by an angiotensin converting enzyme inhibitor prevents the progression of renal damage in hypertensive diabetic rats.

Fabris B, Candido R, Armini L, Fischetti F, Calci M, Bardelli M, Fazio M, Campanacci L, Carretta R.

J Hypertens. 1999 Dec;17(12 Pt 2):1925-31.


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