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Items: 1 to 20 of 143


The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor γt (RORγt) in Th17 cells.

Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B.

J Biol Chem. 2014 Sep 12;289(37):25546-55. doi: 10.1074/jbc.M114.565291.


AT-rich-interactive domain-containing protein 5A functions as a negative regulator of retinoic acid receptor-related orphan nuclear receptor γt-induced Th17 cell differentiation.

Saito Y, Kagami S, Sanayama Y, Ikeda K, Suto A, Kashiwakuma D, Furuta S, Iwamoto I, Nonaka K, Ohara O, Nakajima H.

Arthritis Rheumatol. 2014 May;66(5):1185-94. doi: 10.1002/art.38324.


TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression.

Wang X, Yang J, Han L, Zhao K, Wu Q, Bao L, Li Z, Lv L, Li B.

J Biol Chem. 2015 Nov 27;290(48):29086-94. doi: 10.1074/jbc.M115.664573.


In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists.

Skepner J, Trocha M, Ramesh R, Qu XA, Schmidt D, Baloglu E, Lobera M, Davis S, Nolan MA, Carlson TJ, Hill J, Ghosh S, Sundrud MS, Yang J.

Immunology. 2015 Jul;145(3):347-56. doi: 10.1111/imm.12444.


Cutting edge: Ubiquitin-specific protease 4 promotes Th17 cell function under inflammation by deubiquitinating and stabilizing RORγt.

Yang J, Xu P, Han L, Guo Z, Wang X, Chen Z, Nie J, Yin S, Piccioni M, Tsun A, Lv L, Ge S, Li B.

J Immunol. 2015 May 1;194(9):4094-7. doi: 10.4049/jimmunol.1401451.


Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo.

Skepner J, Ramesh R, Trocha M, Schmidt D, Baloglu E, Lobera M, Carlson T, Hill J, Orband-Miller LA, Barnes A, Boudjelal M, Sundrud M, Ghosh S, Yang J.

J Immunol. 2014 Mar 15;192(6):2564-75. doi: 10.4049/jimmunol.1302190.


Fyn promotes Th17 differentiation by regulating the kinetics of RORγt and Foxp3 expression.

Ueda A, Zhou L, Stein PL.

J Immunol. 2012 Jun 1;188(11):5247-56. doi: 10.4049/jimmunol.1102241.


Upstream stimulating factors regulate the expression of RORγT in human lymphocytes.

Ratajewski M, Walczak-Drzewiecka A, Salkowska A, Dastych J.

J Immunol. 2012 Sep 15;189(6):3034-42. doi: 10.4049/jimmunol.1200519.


RORγt-specific transcriptional interactomic inhibition suppresses autoimmunity associated with TH17 cells.

Park TY, Park SD, Cho JY, Moon JS, Kim NY, Park K, Seong RH, Lee SW, Morio T, Bothwell AL, Lee SK.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18673-8. doi: 10.1073/pnas.1413687112. Erratum in: Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2115.


RORγt(+) hematopoietic cells are necessary for tumor cell proliferation during colitis-associated tumorigenesis in mice.

Martin M, Kesselring RK, Saidou B, Brunner SM, Schiechl G, Mouris VF, Wege AK, Rümmele P, Schlitt HJ, Geissler EK, Fichtner-Feigl S.

Eur J Immunol. 2015 Jun;45(6):1667-79. doi: 10.1002/eji.201444915.


Transcription of RORγt in developing Th17 cells is regulated by E-proteins.

Zhang F, Fuss IJ, Yang Z, Strober W.

Mucosal Immunol. 2014 May;7(3):521-32. doi: 10.1038/mi.2013.69.


T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice.

Ono Y, Kanai T, Sujino T, Nemoto Y, Kanai Y, Mikami Y, Hayashi A, Matsumoto A, Takaishi H, Ogata H, Matsuoka K, Hisamatsu T, Watanabe M, Hibi T.

Gastroenterology. 2012 Nov;143(5):1288-97. doi: 10.1053/j.gastro.2012.07.108.


Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell Differentiation.

Ding Q, Zhao M, Yu B, Bai C, Huang Z.

PLoS One. 2015 Sep 14;10(9):e0137711. doi: 10.1371/journal.pone.0137711.


Cutting edge: Leptin-induced RORγt expression in CD4+ T cells promotes Th17 responses in systemic lupus erythematosus.

Yu Y, Liu Y, Shi FD, Zou H, Matarese G, La Cava A.

J Immunol. 2013 Apr 1;190(7):3054-8. doi: 10.4049/jimmunol.1203275.


Elevated interferon regulatory factor 4 levels in patients with allergic asthma.

Chen X, Gao YD, Yang J.

J Asthma. 2012 Jun;49(5):441-9. doi: 10.3109/02770903.2012.674998.


IL-17 Producing Cells and RORγt mRNA Transcriptional Factor in Cirrhotic and HCC Egyptian Patients.

El Bassuoni MA, Soliman MA, El Megeed NA, Al Gazar A.

Egypt J Immunol. 2015;22(1):59-68.


Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3.

Tanaka S, Suto A, Iwamoto T, Kashiwakuma D, Kagami S, Suzuki K, Takatori H, Tamachi T, Hirose K, Onodera A, Suzuki J, Ohara O, Yamashita M, Nakayama T, Nakajima H.

J Exp Med. 2014 Aug 25;211(9):1857-74. doi: 10.1084/jem.20130791.


Signaling Pathways and Epigenetic Regulations in the Control of RORγt Expression in T Helper 17 Cells.

Tian Y, Wu Y, Ni B.

Int Rev Immunol. 2015;34(4):305-17. doi: 10.3109/08830185.2014.911858. Review.


Yin-Yang Regulation of RORγt Protein Complex in Th17 Differentiation.

Gao W, Wu Y, Tian Y, Ni B.

Int Rev Immunol. 2015;34(4):295-304. doi: 10.3109/08830185.2014.969423. Review.


Th17 helper cell and T-cell immunoglobulin and mucin domain 3 involvement in Guillain-Barré syndrome.

Liang SL, Wang WZ, Huang S, Wang XK, Zhang S, Wu Y.

Immunopharmacol Immunotoxicol. 2012 Dec;34(6):1039-46. doi: 10.3109/08923973.2012.697469. Erratum in: Immunopharmacol Immunotoxicol. 2013 Apr;35(2):309.

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