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Evidence of a conserved role for Chlamydia HtrA in the replication phase of the chlamydial developmental cycle.

Patel P, De Boer L, Timms P, Huston WM.

Microbes Infect. 2014 Aug;16(8):690-4. doi: 10.1016/j.micinf.2014.07.003. Epub 2014 Jul 25.


The protease inhibitor JO146 demonstrates a critical role for CtHtrA for Chlamydia trachomatis reversion from penicillin persistence.

Ong VA, Marsh JW, Lawrence A, Allan JA, Timms P, Huston WM.

Front Cell Infect Microbiol. 2013 Dec 18;3:100. doi: 10.3389/fcimb.2013.00100. eCollection 2013.


Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis.

Gloeckl S, Ong VA, Patel P, Tyndall JD, Timms P, Beagley KW, Allan JA, Armitage CW, Turnbull L, Whitchurch CB, Merdanovic M, Ehrmann M, Powers JC, Oleksyszyn J, Verdoes M, Bogyo M, Huston WM.

Mol Microbiol. 2013 Aug;89(4):676-89. doi: 10.1111/mmi.12306. Epub 2013 Jul 12.


Chlamydia Serine Protease Inhibitor, targeting HtrA, as a New Treatment for Koala Chlamydia infection.

Lawrence A, Fraser T, Gillett A, Tyndall JD, Timms P, Polkinghorne A, Huston WM.

Sci Rep. 2016 Aug 17;6:31466. doi: 10.1038/srep31466.


In vitro susceptibility of recent Chlamydia trachomatis clinical isolates to the CtHtrA inhibitor JO146.

Ong VA, Lawrence A, Timms P, Vodstrcil LA, Tabrizi SN, Beagley KW, Allan JA, Hocking JS, Huston WM.

Microbes Infect. 2015 Nov-Dec;17(11-12):738-44. doi: 10.1016/j.micinf.2015.09.004. Epub 2015 Sep 11.


Porcine epidemic diarrhea virus (PEDV) co-infection induced chlamydial persistence/stress does not require viral replication.

Schoborg RV, Borel N.

Front Cell Infect Microbiol. 2014 Mar 13;4:20. doi: 10.3389/fcimb.2014.00020. eCollection 2014.


A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production.

Marsh JW, Wee BA, Tyndall JD, Lott WB, Bastidas RJ, Caldwell HD, Valdivia RH, Kari L, Huston WM.

BMC Microbiol. 2015 Sep 30;15:194. doi: 10.1186/s12866-015-0533-2.


the active site residue V266 of Chlamydial HtrA is critical for substrate binding during both in vitro and in vivo conditions.

Gloeckl S, Tyndall JD, Stansfield SH, Timms P, Huston WM.

J Mol Microbiol Biotechnol. 2012;22(1):10-6. doi: 10.1159/000336312. Epub 2012 Feb 21.


Translation inhibition of the developmental cycle protein HctA by the small RNA IhtA is conserved across Chlamydia.

Tattersall J, Rao GV, Runac J, Hackstadt T, Grieshaber SS, Grieshaber NA.

PLoS One. 2012;7(10):e47439. doi: 10.1371/journal.pone.0047439. Epub 2012 Oct 11.


Chlamydia spp. development is differentially altered by treatment with the LpxC inhibitor LPC-011.

Cram ED, Rockey DD, Dolan BP.

BMC Microbiol. 2017 Apr 24;17(1):98. doi: 10.1186/s12866-017-0992-8.


CtHtrA: the lynchpin of the chlamydial surface and a promising therapeutic target.

Marsh JW, Ong VA, Lott WB, Timms P, Tyndall JD, Huston WM.

Future Microbiol. 2017 Jul;12:817-829. doi: 10.2217/fmb-2017-0017. Epub 2017 Jun 8.


The Extracellular Bacterial HtrA Proteins as Potential Therapeutic Targets and Vaccine Candidates.

Skórko-Glonek J, Figaj D, Zarzecka U, Przepiora T, Renke J, Lipinska B.

Curr Med Chem. 2017;24(20):2174-2204. doi: 10.2174/0929867323666161223145825.


The temperature activated HtrA protease from pathogen Chlamydia trachomatis acts as both a chaperone and protease at 37 degrees C.

Huston WM, Swedberg JE, Harris JM, Walsh TP, Mathews SA, Timms P.

FEBS Lett. 2007 Jul 24;581(18):3382-6. Epub 2007 Jun 26.


Specific antigens of Chlamydia pecorum and their homologues in C psittaci and C trachomatis.

Baghian A, Kousoulas K, Truax R, Storz J.

Am J Vet Res. 1996 Dec;57(12):1720-5.


Autoprocessing and self-activation of the secreted protease CPAF in Chlamydia-infected cells.

Chen D, Lei L, Flores R, Huang Z, Wu Z, Chai J, Zhong G.

Microb Pathog. 2010 Oct;49(4):164-73. doi: 10.1016/j.micpath.2010.05.008. Epub 2010 May 25.


Quantitative Proteomics of the Infectious and Replicative Forms of Chlamydia trachomatis.

Skipp PJ, Hughes C, McKenna T, Edwards R, Langridge J, Thomson NR, Clarke IN.

PLoS One. 2016 Feb 12;11(2):e0149011. doi: 10.1371/journal.pone.0149011. eCollection 2016.


Evolutionary relationships among members of the genus Chlamydia based on 16S ribosomal DNA analysis.

Pettersson B, Andersson A, Leitner T, Olsvik O, Uhlén M, Storey C, Black CM.

J Bacteriol. 1997 Jul;179(13):4195-205.


The chlamydial periplasmic stress response serine protease cHtrA is secreted into host cell cytosol.

Wu X, Lei L, Gong S, Chen D, Flores R, Zhong G.

BMC Microbiol. 2011 Apr 28;11:87. doi: 10.1186/1471-2180-11-87.


Nma111p, the pro-apoptotic HtrA-like nuclear serine protease in Saccharomyces cerevisiae: a short survey.

Fahrenkrog B.

Biochem Soc Trans. 2011 Oct;39(5):1499-501. doi: 10.1042/BST0391499. Review.


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