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Regulation of DNA methylation patterns by CK2-mediated phosphorylation of Dnmt3a.

Deplus R, Blanchon L, Rajavelu A, Boukaba A, Defrance M, Luciani J, Rothé F, Dedeurwaerder S, Denis H, Brinkman AB, Simmer F, Müller F, Bertin B, Berdasco M, Putmans P, Calonne E, Litchfield DW, de Launoit Y, Jurkowski TP, Stunnenberg HG, Bock C, Sotiriou C, Fraga MF, Esteller M, Jeltsch A, Fuks F.

Cell Rep. 2014 Aug 7;8(3):743-53. doi: 10.1016/j.celrep.2014.06.048. Epub 2014 Jul 24.


Citrullination of DNMT3A by PADI4 regulates its stability and controls DNA methylation.

Deplus R, Denis H, Putmans P, Calonne E, Fourrez M, Yamamoto K, Suzuki A, Fuks F.

Nucleic Acids Res. 2014 Jul;42(13):8285-96. doi: 10.1093/nar/gku522. Epub 2014 Jun 23.


Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation.

Baubec T, Colombo DF, Wirbelauer C, Schmidt J, Burger L, Krebs AR, Akalin A, Schübeler D.

Nature. 2015 Apr 9;520(7546):243-7. doi: 10.1038/nature14176. Epub 2015 Jan 21.


DNA methyltransferase-3a interacts with p53 and represses p53-mediated gene expression.

Wang YA, Kamarova Y, Shen KC, Jiang Z, Hahn MJ, Wang Y, Brooks SC.

Cancer Biol Ther. 2005 Oct;4(10):1138-43. Epub 2005 Oct 1.


Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation.

Jia D, Jurkowska RZ, Zhang X, Jeltsch A, Cheng X.

Nature. 2007 Sep 13;449(7159):248-51. Epub 2007 Aug 22.


Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain.

Otani J, Nankumo T, Arita K, Inamoto S, Ariyoshi M, Shirakawa M.

EMBO Rep. 2009 Nov;10(11):1235-41. doi: 10.1038/embor.2009.218. Epub 2009 Oct 16.


Preferential methylation of unmethylated DNA by Mammalian de novo DNA methyltransferase Dnmt3a.

Yokochi T, Robertson KD.

J Biol Chem. 2002 Apr 5;277(14):11735-45. Epub 2002 Jan 30.


Structural insight into autoinhibition and histone H3-induced activation of DNMT3A.

Guo X, Wang L, Li J, Ding Z, Xiao J, Yin X, He S, Shi P, Dong L, Li G, Tian C, Wang J, Cong Y, Xu Y.

Nature. 2015 Jan 29;517(7536):640-4. doi: 10.1038/nature13899. Epub 2014 Nov 10.


Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse.

Kato Y, Kaneda M, Hata K, Kumaki K, Hisano M, Kohara Y, Okano M, Li E, Nozaki M, Sasaki H.

Hum Mol Genet. 2007 Oct 1;16(19):2272-80. Epub 2007 Jul 6.


Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin.

Bachman KE, Rountree MR, Baylin SB.

J Biol Chem. 2001 Aug 24;276(34):32282-7. Epub 2001 Jun 26.


Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements.

Liang G, Chan MF, Tomigahara Y, Tsai YC, Gonzales FA, Li E, Laird PW, Jones PA.

Mol Cell Biol. 2002 Jan;22(2):480-91.


The de novo methyltransferases DNMT3a and DNMT3b target the murine gammaherpesvirus immediate-early gene 50 promoter during establishment of latency.

Gray KS, Forrest JC, Speck SH.

J Virol. 2010 May;84(10):4946-59. doi: 10.1128/JVI.00060-10. Epub 2010 Mar 3.


Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase.

Li BZ, Huang Z, Cui QY, Song XH, Du L, Jeltsch A, Chen P, Li G, Li E, Xu GL.

Cell Res. 2011 Aug;21(8):1172-81. doi: 10.1038/cr.2011.92. Epub 2011 May 24.


The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells.

Li H, Rauch T, Chen ZX, Szabó PE, Riggs AD, Pfeifer GP.

J Biol Chem. 2006 Jul 14;281(28):19489-500. Epub 2006 May 8.


Polycomb protein Cbx4 promotes SUMO modification of de novo DNA methyltransferase Dnmt3a.

Li B, Zhou J, Liu P, Hu J, Jin H, Shimono Y, Takahashi M, Xu G.

Biochem J. 2007 Jul 15;405(2):369-78.


De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases.

Gowher H, Stockdale CJ, Goyal R, Ferreira H, Owen-Hughes T, Jeltsch A.

Biochemistry. 2005 Jul 26;44(29):9899-904.


Structure and function of mammalian DNA methyltransferases.

Jurkowska RZ, Jurkowski TP, Jeltsch A.

Chembiochem. 2011 Jan 24;12(2):206-22. doi: 10.1002/cbic.201000195. Epub 2010 Nov 29. Review.


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