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Items: 1 to 20 of 88


eSNaPD: a versatile, web-based bioinformatics platform for surveying and mining natural product biosynthetic diversity from metagenomes.

Reddy BV, Milshteyn A, Charlop-Powers Z, Brady SF.

Chem Biol. 2014 Aug 14;21(8):1023-33. doi: 10.1016/j.chembiol.2014.06.007. Epub 2014 Jul 24.


Mining soil metagenomes to better understand the evolution of natural product structural diversity: pentangular polyphenols as a case study.

Kang HS, Brady SF.

J Am Chem Soc. 2014 Dec 31;136(52):18111-9. doi: 10.1021/ja510606j. Epub 2014 Dec 18.


Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products.

Owen JG, Reddy BV, Ternei MA, Charlop-Powers Z, Calle PY, Kim JH, Brady SF.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11797-802. doi: 10.1073/pnas.1222159110. Epub 2013 Jul 3.


Computational approaches to natural product discovery.

Medema MH, Fischbach MA.

Nat Chem Biol. 2015 Sep;11(9):639-48. doi: 10.1038/nchembio.1884.


Culture-independent discovery of natural products from soil metagenomes.

Katz M, Hover BM, Brady SF.

J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):129-41. doi: 10.1007/s10295-015-1706-6. Epub 2015 Nov 19. Review.


Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors.

Owen JG, Charlop-Powers Z, Smith AG, Ternei MA, Calle PY, Reddy BV, Montiel D, Brady SF.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4221-6. doi: 10.1073/pnas.1501124112. Epub 2015 Mar 23.


Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining.

Skinnider MA, Johnston CW, Edgar RE, Dejong CA, Merwin NJ, Rees PN, Magarvey NA.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6343-E6351. Epub 2016 Oct 3.


Natural product biosynthetic gene diversity in geographically distinct soil microbiomes.

Reddy BV, Kallifidas D, Kim JH, Charlop-Powers Z, Feng Z, Brady SF.

Appl Environ Microbiol. 2012 May;78(10):3744-52. doi: 10.1128/AEM.00102-12. Epub 2012 Mar 16.


Discovery of the leinamycin family of natural products by mining actinobacterial genomes.

Pan G, Xu Z, Guo Z, Hindra, Ma M, Yang D, Zhou H, Gansemans Y, Zhu X, Huang Y, Zhao LX, Jiang Y, Cheng J, Van Nieuwerburgh F, Suh JW, Duan Y, Shen B.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11131-E11140. doi: 10.1073/pnas.1716245115. Epub 2017 Dec 11.


Expanding our understanding of sequence-function relationships of type II polyketide biosynthetic gene clusters: bioinformatics-guided identification of Frankiamicin A from Frankia sp. EAN1pec.

Ogasawara Y, Yackley BJ, Greenberg JA, Rogelj S, Melançon CE 3rd.

PLoS One. 2015 Apr 2;10(4):e0121505. doi: 10.1371/journal.pone.0121505. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0129408.


Bacterial natural product biosynthetic domain composition in soil correlates with changes in latitude on a continent-wide scale.

Lemetre C, Maniko J, Charlop-Powers Z, Sparrow B, Lowe AJ, Brady SF.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11615-11620. doi: 10.1073/pnas.1710262114. Epub 2017 Oct 18.


Computational strategies for genome-based natural product discovery and engineering in fungi.

van der Lee TAJ, Medema MH.

Fungal Genet Biol. 2016 Apr;89:29-36. doi: 10.1016/j.fgb.2016.01.006. Epub 2016 Jan 13. Review.


Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria.

Dittmann E, Gugger M, Sivonen K, Fewer DP.

Trends Microbiol. 2015 Oct;23(10):642-652. doi: 10.1016/j.tim.2015.07.008. Review.


Phylogeny-guided (meta)genome mining approach for the targeted discovery of new microbial natural products.

Kang HS.

J Ind Microbiol Biotechnol. 2017 Feb;44(2):285-293. doi: 10.1007/s10295-016-1874-z. Epub 2016 Nov 24. Review.


Global biogeographic sampling of bacterial secondary metabolism.

Charlop-Powers Z, Owen JG, Reddy BV, Ternei MA, Guimarães DO, de Frias UA, Pupo MT, Seepe P, Feng Z, Brady SF.

Elife. 2015 Jan 19;4:e05048. doi: 10.7554/eLife.05048.


Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743.

Rath CM, Janto B, Earl J, Ahmed A, Hu FZ, Hiller L, Dahlgren M, Kreft R, Yu F, Wolff JJ, Kweon HK, Christiansen MA, Håkansson K, Williams RM, Ehrlich GD, Sherman DH.

ACS Chem Biol. 2011 Nov 18;6(11):1244-56. doi: 10.1021/cb200244t. Epub 2011 Sep 20.


Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes.

Ju KS, Gao J, Doroghazi JR, Wang KK, Thibodeaux CJ, Li S, Metzger E, Fudala J, Su J, Zhang JK, Lee J, Cioni JP, Evans BS, Hirota R, Labeda DP, van der Donk WA, Metcalf WW.

Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12175-80. doi: 10.1073/pnas.1500873112. Epub 2015 Aug 31.


Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters.

Montiel D, Kang HS, Chang FY, Charlop-Powers Z, Brady SF.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):8953-8. doi: 10.1073/pnas.1507606112. Epub 2015 Jul 6.


Mining the metabiome: identifying novel natural products from microbial communities.

Milshteyn A, Schneider JS, Brady SF.

Chem Biol. 2014 Sep 18;21(9):1211-23. doi: 10.1016/j.chembiol.2014.08.006. Review.


The evolution of genome mining in microbes - a review.

Ziemert N, Alanjary M, Weber T.

Nat Prod Rep. 2016 Aug 27;33(8):988-1005. doi: 10.1039/c6np00025h. Epub 2016 Jun 8. Review.


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