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Items: 1 to 20 of 169

1.

A novel functional site in the PB2 subunit of influenza A virus essential for acetyl-CoA interaction, RNA polymerase activity, and viral replication.

Hatakeyama D, Shoji M, Yamayoshi S, Hirota T, Nagae M, Yanagisawa S, Nakano M, Ohmi N, Noda T, Kawaoka Y, Kuzuhara T.

J Biol Chem. 2014 Sep 5;289(36):24980-94. doi: 10.1074/jbc.M114.559708. Epub 2014 Jul 25.

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Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus.

Liu Y, Qin K, Meng G, Zhang J, Zhou J, Zhao G, Luo M, Zheng X.

J Biol Chem. 2013 Apr 19;288(16):11013-23. doi: 10.1074/jbc.M112.392878. Epub 2013 Feb 22.

4.

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit.

Dias A, Bouvier D, Crépin T, McCarthy AA, Hart DJ, Baudin F, Cusack S, Ruigrok RW.

Nature. 2009 Apr 16;458(7240):914-8. doi: 10.1038/nature07745. Epub 2009 Feb 4.

PMID:
19194459
6.

Role of the PB2 627 Domain in Influenza A Virus Polymerase Function.

Nilsson BE, Te Velthuis AJ, Fodor E.

J Virol. 2017 Mar 13;91(7). pii: e02467-16. doi: 10.1128/JVI.02467-16. Print 2017 Apr 1.

7.

A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs.

Fodor E, Crow M, Mingay LJ, Deng T, Sharps J, Fechter P, Brownlee GG.

J Virol. 2002 Sep;76(18):8989-9001.

8.

The structural basis for cap binding by influenza virus polymerase subunit PB2.

Guilligay D, Tarendeau F, Resa-Infante P, Coloma R, Crepin T, Sehr P, Lewis J, Ruigrok RW, Ortin J, Hart DJ, Cusack S.

Nat Struct Mol Biol. 2008 May;15(5):500-6. doi: 10.1038/nsmb.1421. Epub 2008 May 4.

PMID:
18454157
9.

Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription.

Reguera J, Weber F, Cusack S.

PLoS Pathog. 2010 Sep 16;6(9):e1001101. doi: 10.1371/journal.ppat.1001101.

10.

Identification of a Novel Viral Protein Expressed from the PB2 Segment of Influenza A Virus.

Yamayoshi S, Watanabe M, Goto H, Kawaoka Y.

J Virol. 2015 Oct 21;90(1):444-56. doi: 10.1128/JVI.02175-15.

11.

Temperature-Sensitive Mutants in the Influenza A Virus RNA Polymerase: Alterations in the PA Linker Reduce Nuclear Targeting of the PB1-PA Dimer and Result in Viral Attenuation.

Da Costa B, Sausset A, Munier S, Ghounaris A, Naffakh N, Le Goffic R, Delmas B.

J Virol. 2015 Jun;89(12):6376-90. doi: 10.1128/JVI.00589-15. Epub 2015 Apr 8.

12.

Biophysical characterization of sites of host adaptive mutation in the influenza A virus RNA polymerase PB2 RNA-binding domain.

Lim K, Kim M, Lee MK, Ko J, Hong S, Choi BS.

Int J Biochem Cell Biol. 2014 Aug;53:237-45. doi: 10.1016/j.biocel.2014.05.022. Epub 2014 May 27.

PMID:
24875650
13.

Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit.

Tarendeau F, Crepin T, Guilligay D, Ruigrok RW, Cusack S, Hart DJ.

PLoS Pathog. 2008 Aug 29;4(8):e1000136. doi: 10.1371/journal.ppat.1000136.

14.

Conserved features of the PB2 627 domain impact influenza virus polymerase function and replication.

Kirui J, Bucci MD, Poole DS, Mehle A.

J Virol. 2014 Jun;88(11):5977-86. doi: 10.1128/JVI.00508-14. Epub 2014 Mar 12.

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The N terminus of PA polymerase of swine-origin influenza virus H1N1 determines its compatibility with PB2 and PB1 subunits through a strain-specific amino acid serine 186.

Wanitchang A, Jengarn J, Jongkaewwattana A.

Virus Res. 2011 Jan;155(1):325-33. doi: 10.1016/j.virusres.2010.10.032. Epub 2010 Nov 5.

PMID:
21056603
18.

Specific residues of PB2 and PA influenza virus polymerase subunits confer the ability for RNA polymerase II degradation and virus pathogenicity in mice.

Llompart CM, Nieto A, Rodriguez-Frandsen A.

J Virol. 2014 Mar;88(6):3455-63. doi: 10.1128/JVI.02263-13. Epub 2014 Jan 8.

19.

Replication and transcription activities of ribonucleoprotein complexes reconstituted from avian H5N1, H1N1pdm09 and H3N2 influenza A viruses.

Ngai KL, Chan MC, Chan PK.

PLoS One. 2013 Jun 4;8(6):e65038. doi: 10.1371/journal.pone.0065038. Print 2013.

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