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Items: 1 to 20 of 195

1.

Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo.

Zhang X, Hu X, Mu S, Zhan Y, An Q, Liu Z, Huang X.

Mol Med Rep. 2014 Sep;10(3):1184-94. doi: 10.3892/mmr.2014.2379. Epub 2014 Jul 14.

2.

Apogossypolone induces autophagy and apoptosis in breast cancer MCF-7 cells in vitro and in vivo.

Niu X, Li S, Wei F, Huang J, Wu G, Xu L, Xu D, Wang S.

Breast Cancer. 2014 Mar;21(2):223-30. doi: 10.1007/s12282-012-0372-z. Epub 2012 Jun 19.

PMID:
22711315
3.

Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma.

Mi JX, Wang GF, Wang HB, Sun XQ, Ni XY, Zhang XW, Tang JM, Yang DJ.

Acta Pharmacol Sin. 2008 Dec;29(12):1467-77. doi: 10.1111/j.1745-7254.2008.00901.x.

4.

Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo.

Sun Y, Wu J, Aboukameel A, Banerjee S, Arnold AA, Chen J, Nikolovska-Coleska Z, Lin Y, Ling X, Yang D, Wang S, Al-Katib A, Mohammad RM.

Cancer Biol Ther. 2008 Sep;7(9):1418-26. Epub 2008 Sep 4.

5.

Apogossypolone, a small-molecule inhibitor of Bcl-2, induces radiosensitization of nasopharyngeal carcinoma cells by stimulating autophagy.

He JH, Liao XL, Wang W, Li DD, Chen WD, Deng R, Yang D, Han ZP, Jiang JW, Zhu XF.

Int J Oncol. 2014 Sep;45(3):1099-108. doi: 10.3892/ijo.2014.2497. Epub 2014 Jun 11.

PMID:
24919770
6.

ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells.

Xin J, Zhan YH, Xia LM, Zhu HW, Nie YZ, Liang JM, Tian J.

Biomed Pharmacother. 2013 Feb;67(1):88-95. doi: 10.1016/j.biopha.2012.10.016. Epub 2012 Nov 19.

PMID:
23201009
7.

Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro.

Zhang XQ, Huang XF, Hu XB, Zhan YH, An QX, Yang SM, Xia AJ, Yi J, Chen R, Mu SJ, Wu DC.

Asian J Androl. 2010 Sep;12(5):697-708. doi: 10.1038/aja.2010.57. Epub 2010 Jul 26.

8.

[Effect of apogossypolone on induction apoptosis in multiple myeloma cells and its mechanisms].

Lin J, Wu YJ, Yang DJ, Zhao YQ.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Feb;17(1):92-8. Chinese.

PMID:
19236755
9.

Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using (-)-gossypol.

Zhang XQ, Huang XF, Mu SJ, An QX, Xia AJ, Chen R, Wu DC.

Asian J Androl. 2010 May;12(3):390-9. doi: 10.1038/aja.2009.87. Epub 2010 Jan 18.

10.

ApoG2 inhibits the antiapoptotic protein, Mcl‑1, and induces mitochondria‑dependent apoptosis in human colorectal cancer cells.

Li T, Yuan G, Zhang L, Ye L, Li S, Fan Y, Sun J.

Mol Med Rep. 2015 Nov;12(5):6976-84. doi: 10.3892/mmr.2015.4299. Epub 2015 Sep 8.

PMID:
26352605
11.

ApoG2 inhibits antiapoptotic Bcl-2 family proteins and induces mitochondria-dependent apoptosis in human lymphoma U937 cells.

Sun J, Li ZM, Hu ZY, Lin XB, Zhou NN, Xian LJ, Yang DJ, Jiang WQ.

Anticancer Drugs. 2008 Nov;19(10):967-74. doi: 10.1097/CAD.0b013e32831087e8.

PMID:
18827561
12.

Gambogic acid induces apoptosis and inhibits colorectal tumor growth via mitochondrial pathways.

Huang GM, Sun Y, Ge X, Wan X, Li CB.

World J Gastroenterol. 2015 May 28;21(20):6194-205. doi: 10.3748/wjg.v21.i20.6194.

13.

The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells.

Cheng P, Ni Z, Dai X, Wang B, Ding W, Rae Smith A, Xu L, Wu D, He F, Lian J.

Cell Death Dis. 2013 Feb 7;4:e489. doi: 10.1038/cddis.2013.17. Erratum in: Cell Death Dis. 2013;4:e598.

14.

Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2 and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells.

Banerjee S, Choi M, Aboukameel A, Wang Z, Mohammad M, Chen J, Yang D, Sarkar FH, Mohammad RM.

Pancreas. 2010 Apr;39(3):323-31. doi: 10.1097/MPA.0b013e3181bb95e7.

15.

Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells.

Sun J, Li ZM, Hu ZY, Zeng ZL, Yang DJ, Jiang WQ.

Oncol Rep. 2009 Jul;22(1):193-8.

PMID:
19513523
16.

Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo.

Lin J, Wu Y, Yang D, Zhao Y.

Oncol Rep. 2013 Aug;30(2):731-8. doi: 10.3892/or.2013.2489. Epub 2013 May 23.

PMID:
23708869
17.

ApoG2, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces apoptosis and suppresses tumor growth in nasopharyngeal carcinoma xenografts.

Hu ZY, Zhu XF, Zhong ZD, Sun J, Wang J, Yang D, Zeng YX.

Int J Cancer. 2008 Nov 15;123(10):2418-29. doi: 10.1002/ijc.23752. Erratum in: Int J Cancer. 2009 Jan 15;124(2):510.

18.

Autophagy blockade sensitizes the anticancer activity of CA-4 via JNK-Bcl-2 pathway.

Li Y, Luo P, Wang J, Dai J, Yang X, Wu H, Yang B, He Q.

Toxicol Appl Pharmacol. 2014 Jan 15;274(2):319-27. doi: 10.1016/j.taap.2013.11.018. Epub 2013 Dec 7.

PMID:
24321340
19.

Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo.

Zhan W, Hu X, Yi J, An Q, Huang X.

Mol Med Rep. 2015 Jun;11(6):4142-8. doi: 10.3892/mmr.2015.3326. Epub 2015 Feb 10.

20.

Apogossypolone induces apoptosis and autophagy in nasopharyngeal carcinoma cells in an in vitro and in vivo study.

Zheng R, Chen K, Zhang Y, Huang J, Shi F, Wu G, Wang S.

Oncol Lett. 2017 Jul;14(1):751-757. doi: 10.3892/ol.2017.6176. Epub 2017 May 16.

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