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Items: 1 to 20 of 177

1.

Effect of valproic acid and injury on lesion size and endothelial glycocalyx shedding in a rodent model of isolated traumatic brain injury.

Jepsen CH, deMoya MA, Perner A, Sillesen M, Ostrowski SR, Alam HB, Johansson PI.

J Trauma Acute Care Surg. 2014 Aug;77(2):292-7. doi: 10.1097/TA.0000000000000333.

PMID:
25058256
2.

Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury.

Jin G, Duggan M, Imam A, Demoya MA, Sillesen M, Hwabejire J, Jepsen CH, Liu B, Mejaddam AY, Lu J, Smith WM, Velmahos GC, Socrate S, Alam HB.

J Trauma Acute Care Surg. 2012 Dec;73(6):1461-70. doi: 10.1097/TA.0b013e3182782641.

PMID:
23188239
3.

Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock.

Dekker SE, Sillesen M, Bambakidis T, Andjelkovic AV, Jin G, Liu B, Boer C, Johansson PI, Linzel D, Halaweish I, Alam HB.

J Surg Res. 2014 Jul;190(1):312-8. doi: 10.1016/j.jss.2014.02.049. Epub 2014 Mar 1.

PMID:
24694719
4.

Synergistic effects of fresh frozen plasma and valproic acid treatment in a combined model of traumatic brain injury and hemorrhagic shock.

Imam AM, Jin G, Duggan M, Sillesen M, Hwabejire JO, Jepsen CH, DePeralta D, Liu B, Lu J, deMoya MA, Socrate S, Alam HB.

Surgery. 2013 Aug;154(2):388-96. doi: 10.1016/j.surg.2013.05.008.

PMID:
23889966
5.

Addition of low-dose valproic acid to saline resuscitation provides neuroprotection and improves long-term outcomes in a large animal model of combined traumatic brain injury and hemorrhagic shock.

Halaweish I, Bambakidis T, Chang Z, Wei H, Liu B, Li Y, Bonthrone T, Srinivasan A, Bonham T, Chtraklin K, Alam HB.

J Trauma Acute Care Surg. 2015 Dec;79(6):911-9; discussion 919. doi: 10.1097/TA.0000000000000789.

PMID:
26680134
6.

Effect of pharmacologic resuscitation on the brain gene expression profiles in a swine model of traumatic brain injury and hemorrhage.

Dekker SE, Bambakidis T, Sillesen M, Liu B, Johnson CN, Jin G, Li Y, Alam HB.

J Trauma Acute Care Surg. 2014 Dec;77(6):906-12; discussion 912. doi: 10.1097/TA.0000000000000345.

PMID:
25051383
7.

Pharmacologic modulation of cerebral metabolic derangement and excitotoxicity in a porcine model of traumatic brain injury and hemorrhagic shock.

Hwabejire JO, Jin G, Imam AM, Duggan M, Sillesen M, Deperalta D, Jepsen CH, Lu J, Li Y, deMoya MA, Alam HB.

Surgery. 2013 Aug;154(2):234-43. doi: 10.1016/j.surg.2013.04.008.

PMID:
23889951
8.

Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma.

Nikolian VC, Georgoff PE, Pai MP, Dennahy IS, Chtraklin K, Eidy H, Ghandour MH, Han Y, Srinivasan A, Li Y, Alam HB.

J Trauma Acute Care Surg. 2017 Dec;83(6):1066-1073. doi: 10.1097/TA.0000000000001612.

PMID:
28697014
9.

Neuroprotection by acetyl-L-carnitine after traumatic injury to the immature rat brain.

Scafidi S, Racz J, Hazelton J, McKenna MC, Fiskum G.

Dev Neurosci. 2010;32(5-6):480-7. doi: 10.1159/000323178. Epub 2011 Jan 12.

10.

Assessment of coagulopathy, endothelial injury, and inflammation after traumatic brain injury and hemorrhage in a porcine model.

Sillesen M, Rasmussen LS, Jin G, Jepsen CH, Imam A, Hwabejire JO, Halaweish I, DeMoya M, Velmahos G, Johansson PI, Alam HB.

J Trauma Acute Care Surg. 2014 Jan;76(1):12-9; discussion 19-20. doi: 10.1097/TA.0b013e3182aaa675.

PMID:
24368352
11.

MLC901, a Traditional Chinese Medicine induces neuroprotective and neuroregenerative benefits after traumatic brain injury in rats.

Quintard H, Lorivel T, Gandin C, Lazdunski M, Heurteaux C.

Neuroscience. 2014 Sep 26;277:72-86. doi: 10.1016/j.neuroscience.2014.06.047. Epub 2014 Jun 30. Erratum in: Neuroscience. 2014 Oct 10;278:265-6.

12.

Posttrauma cotreatment with lithium and valproate: reduction of lesion volume, attenuation of blood-brain barrier disruption, and improvement in motor coordination in mice with traumatic brain injury.

Yu F, Wang Z, Tanaka M, Chiu CT, Leeds P, Zhang Y, Chuang DM.

J Neurosurg. 2013 Sep;119(3):766-73. doi: 10.3171/2013.6.JNS13135. Epub 2013 Jul 12.

PMID:
23848820
13.

Effect of valproic acid on survival and neurologic outcomes in an asphyxial cardiac arrest model of rats.

Lee JH, Kim K, Jo YH, Lee SH, Kang C, Kim J, Park CJ, Kim MA, Lee MJ, Rhee JE.

Resuscitation. 2013 Oct;84(10):1443-9. doi: 10.1016/j.resuscitation.2013.04.027. Epub 2013 May 4.

PMID:
23648213
14.

Neuroprotective and anti-apoptotic effects of valproic acid on adult rat cerebral cortex through ERK and Akt signaling pathway at acute phase of traumatic brain injury.

Zhang C, Zhu J, Zhang J, Li H, Zhao Z, Liao Y, Wang X, Su J, Sang S, Yuan X, Liu Q.

Brain Res. 2014 Mar 25;1555:1-9. doi: 10.1016/j.brainres.2014.01.051. Epub 2014 Feb 5. Erratum in: Brain Res. 2016 Nov 1;1650:283.

PMID:
24508577
15.

Effect of unfractionated heparin on endothelial glycocalyx in a septic shock model.

Yini S, Heng Z, Xin A, Xiaochun M.

Acta Anaesthesiol Scand. 2015 Feb;59(2):160-9. doi: 10.1111/aas.12418. Epub 2014 Oct 14.

PMID:
25312742
16.

Diminution of metabolism/blood flow uncoupling following traumatic brain injury in rats in response to high-dose human albumin treatment.

Ginsberg MD, Zhao W, Belayev L, Alonso OF, Liu Y, Loor JY, Busto R.

J Neurosurg. 2001 Mar;94(3):499-509.

PMID:
11235957
17.

Creating a prosurvival phenotype through a histone deacetylase inhibitor in a lethal two-hit model.

Liu Z, Li Y, Chong W, Deperalta DK, Duan X, Liu B, Halaweish I, Zhou P, Alam HB.

Shock. 2014 Feb;41(2):104-8. doi: 10.1097/SHK.0000000000000074.

18.

Treatment with low-dose methamphetamine improves behavioral and cognitive function after severe traumatic brain injury.

Rau TF, Kothiwal AS, Rova AR, Brooks DM, Poulsen DJ.

J Trauma Acute Care Surg. 2012 Aug;73(2 Suppl 1):S165-72. doi: 10.1097/TA.0b013e318260896a.

PMID:
22847088
20.

Low dose of valproate improves motor function after traumatic brain injury.

Tai YT, Lee WY, Lee FP, Lin TJ, Shih CL, Wang JY, Chiu WT, Hung KS.

Biomed Res Int. 2014;2014:980657. doi: 10.1155/2014/980657. Epub 2014 Feb 6.

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