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Selective deletion of leptin receptors in gonadotropes reveals activin and GnRH-binding sites as leptin targets in support of fertility.

Akhter N, CarlLee T, Syed MM, Odle AK, Cozart MA, Haney AC, Allensworth-James ML, Beneš H, Childs GV.

Endocrinology. 2014 Oct;155(10):4027-42. doi: 10.1210/en.2014-1132. Epub 2014 Jul 24.


Leptin indirectly regulates gonadotropin-releasing hormone neuronal function.

Quennell JH, Mulligan AC, Tups A, Liu X, Phipps SJ, Kemp CJ, Herbison AE, Grattan DR, Anderson GM.

Endocrinology. 2009 Jun;150(6):2805-12. doi: 10.1210/en.2008-1693. Epub 2009 Jan 29.


Leptin receptor null mice with reexpression of LepR in GnRHR expressing cells display elevated FSH levels but remain in a prepubertal state.

Allen SJ, Garcia-Galiano D, Borges BC, Burger LL, Boehm U, Elias CF.

Am J Physiol Regul Integr Comp Physiol. 2016 Jun 1;310(11):R1258-66. doi: 10.1152/ajpregu.00529.2015. Epub 2016 Apr 13.


Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence.

Odle AK, Akhter N, Syed MM, Allensworth-James ML, Beneš H, Melgar Castillo AI, MacNicol MC, MacNicol AM, Childs GV.

Front Endocrinol (Lausanne). 2018 Jan 5;8:367. doi: 10.3389/fendo.2017.00367. eCollection 2017.


Cell-specific transcriptional regulation of follicle-stimulating hormone-beta by activin and gonadotropin-releasing hormone in the LbetaT2 pituitary gonadotrope cell model.

Pernasetti F, Vasilyev VV, Rosenberg SB, Bailey JS, Huang HJ, Miller WL, Mellon PL.

Endocrinology. 2001 Jun;142(6):2284-95.


Bone morphogenetic protein-4 interacts with activin and GnRH to modulate gonadotrophin secretion in LbetaT2 gonadotrophs.

Nicol L, Faure MO, McNeilly JR, Fontaine J, Taragnat C, McNeilly AS.

J Endocrinol. 2008 Mar;196(3):497-507. doi: 10.1677/JOE-07-0542.


Leptin Signaling in AgRP Neurons Modulates Puberty Onset and Adult Fertility in Mice.

Egan OK, Inglis MA, Anderson GM.

J Neurosci. 2017 Apr 5;37(14):3875-3886. doi: 10.1523/JNEUROSCI.3138-16.2017. Epub 2017 Mar 8.


LIM homeodomain transcription factor Isl-1 enhances follicle stimulating hormone-beta and luteinizing hormone-beta gene expression and mediates the activation of leptin on gonadotropin synthesis.

Wu Y, Luo H, Liu J, Kang D, McNeilly AS, Cui S.

Endocrinology. 2010 Oct;151(10):4787-800. doi: 10.1210/en.2010-0208. Epub 2010 Aug 11.


Sex Differences in Somatotrope Dependency on Leptin Receptors in Young Mice: Ablation of LEPR Causes Severe Growth Hormone Deficiency and Abdominal Obesity in Males.

Allensworth-James ML, Odle A, Haney A, Childs G.

Endocrinology. 2015 Sep;156(9):3253-64. doi: 10.1210/EN.2015-1198. Epub 2015 Jul 13.


Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression.

Odle AK, Beneš H, Melgar Castillo A, Akhter N, Syed M, Haney A, Allensworth-James M, Hardy L, Winter B, Manoharan R, Syed R, MacNicol MC, MacNicol AM, Childs GV.

Endocrinology. 2018 Feb 1;159(2):883-894. doi: 10.1210/en.2017-00586.


Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone.

Martin C, Navarro VM, Simavli S, Vong L, Carroll RS, Lowell BB, Kaiser UB.

J Neurosci. 2014 Apr 23;34(17):6047-56. doi: 10.1523/JNEUROSCI.3003-13.2014.


Leptin increases L-type Ca2+ channel expression and GnRH-stimulated LH release in LbetaT2 gonadotropes.

Avelino-Cruz JE, Flores A, Cebada J, Mellon PL, Felix R, Monjaraz E.

Mol Cell Endocrinol. 2009 Jan 27;298(1-2):57-65. doi: 10.1016/j.mce.2008.09.003. Epub 2008 Sep 11.


The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity.

Childs GV, Akhter N, Haney A, Syed M, Odle A, Cozart M, Brodrick Z, Gaddy D, Suva LJ, Akel N, Crane C, Benes H, Charlesworth A, Luque R, Chua S, Kineman RD.

Endocrinology. 2011 Jan;152(1):69-81. doi: 10.1210/en.2010-0498. Epub 2010 Nov 17.


Leptin signaling in GABA neurons, but not glutamate neurons, is required for reproductive function.

Zuure WA, Roberts AL, Quennell JH, Anderson GM.

J Neurosci. 2013 Nov 6;33(45):17874-83. doi: 10.1523/JNEUROSCI.2278-13.2013.

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