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Placenta passage of the thyroid hormone analog DITPA to male wild-type and Mct8-deficient mice.

Ferrara AM, Liao XH, Gil-Ibáñez P, Bernal J, Weiss RE, Dumitrescu AM, Refetoff S.

Endocrinology. 2014 Oct;155(10):4088-93. doi: 10.1210/en.2014-1085. Epub 2014 Jul 22.


The Thyroid Hormone Analog DITPA Ameliorates Metabolic Parameters of Male Mice With Mct8 Deficiency.

Ferrara AM, Liao XH, Ye H, Weiss RE, Dumitrescu AM, Refetoff S.

Endocrinology. 2015 Nov;156(11):3889-94. doi: 10.1210/en.2015-1234. Epub 2015 Aug 31.


A thyroid hormone analog with reduced dependence on the monocarboxylate transporter 8 for tissue transport.

Di Cosmo C, Liao XH, Dumitrescu AM, Weiss RE, Refetoff S.

Endocrinology. 2009 Sep;150(9):4450-8. doi: 10.1210/en.2009-0209. Epub 2009 Jun 4.


Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice.

Dumitrescu AM, Liao XH, Weiss RE, Millen K, Refetoff S.

Endocrinology. 2006 Sep;147(9):4036-43. Epub 2006 May 18.


Diiodothyropropionic acid (DITPA) in the treatment of MCT8 deficiency.

Verge CF, Konrad D, Cohen M, Di Cosmo C, Dumitrescu AM, Marcinkowski T, Hameed S, Hamilton J, Weiss RE, Refetoff S.

J Clin Endocrinol Metab. 2012 Dec;97(12):4515-23. doi: 10.1210/jc.2012-2556. Epub 2012 Sep 19.


Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion.

Di Cosmo C, Liao XH, Dumitrescu AM, Philp NJ, Weiss RE, Refetoff S.

J Clin Invest. 2010 Sep;120(9):3377-88. doi: 10.1172/JCI42113. Epub 2010 Aug 2.


Changes in thyroid status during perinatal development of MCT8-deficient male mice.

Ferrara AM, Liao XH, Gil-Ibáñez P, Marcinkowski T, Bernal J, Weiss RE, Dumitrescu AM, Refetoff S.

Endocrinology. 2013 Jul;154(7):2533-41. doi: 10.1210/en.2012-2031. Epub 2013 May 21.


Mct8-deficient mice have increased energy expenditure and reduced fat mass that is abrogated by normalization of serum T3 levels.

Di Cosmo C, Liao XH, Ye H, Ferrara AM, Weiss RE, Refetoff S, Dumitrescu AM.

Endocrinology. 2013 Dec;154(12):4885-95. doi: 10.1210/en.2013-1150. Epub 2013 Sep 12.


Tissue-specific alterations in thyroid hormone homeostasis in combined Mct10 and Mct8 deficiency.

Müller J, Mayerl S, Visser TJ, Darras VM, Boelen A, Frappart L, Mariotta L, Verrey F, Heuer H.

Endocrinology. 2014 Jan;155(1):315-25. doi: 10.1210/en.2013-1800. Epub 2013 Dec 20.


Distinct roles of deiodinases on the phenotype of Mct8 defect: a comparison of eight different mouse genotypes.

Liao XH, Di Cosmo C, Dumitrescu AM, Hernandez A, Van Sande J, St Germain DL, Weiss RE, Galton VA, Refetoff S.

Endocrinology. 2011 Mar;152(3):1180-91. doi: 10.1210/en.2010-0900. Epub 2011 Feb 1.


Consequences of monocarboxylate transporter 8 deficiency for renal transport and metabolism of thyroid hormones in mice.

Trajkovic-Arsic M, Visser TJ, Darras VM, Friesema EC, Schlott B, Mittag J, Bauer K, Heuer H.

Endocrinology. 2010 Feb;151(2):802-9. doi: 10.1210/en.2009-1053. Epub 2009 Dec 8.


Thyroid hormone-regulated mouse cerebral cortex genes are differentially dependent on the source of the hormone: a study in monocarboxylate transporter-8- and deiodinase-2-deficient mice.

Morte B, Ceballos A, Diez D, Grijota-Martínez C, Dumitrescu AM, Di Cosmo C, Galton VA, Refetoff S, Bernal J.

Endocrinology. 2010 May;151(5):2381-7. doi: 10.1210/en.2009-0944. Epub 2010 Mar 8.


Impact of monocarboxylate transporter-8 deficiency on the hypothalamus-pituitary-thyroid axis in mice.

Trajkovic-Arsic M, Müller J, Darras VM, Groba C, Lee S, Weih D, Bauer K, Visser TJ, Heuer H.

Endocrinology. 2010 Oct;151(10):5053-62. doi: 10.1210/en.2010-0593. Epub 2010 Aug 11.


Tetrac can replace thyroid hormone during brain development in mouse mutants deficient in the thyroid hormone transporter mct8.

Horn S, Kersseboom S, Mayerl S, Müller J, Groba C, Trajkovic-Arsic M, Ackermann T, Visser TJ, Heuer H.

Endocrinology. 2013 Feb;154(2):968-79. doi: 10.1210/en.2012-1628. Epub 2013 Jan 10.


The pathophysiological consequences of thyroid hormone transporter deficiencies: Insights from mouse models.

Heuer H, Visser TJ.

Biochim Biophys Acta. 2013 Jul;1830(7):3974-8. doi: 10.1016/j.bbagen.2012.04.009. Epub 2012 Apr 20. Review.


Monocarboxylate transporter 8 modulates the viability and invasive capacity of human placental cells and fetoplacental growth in mice.

Vasilopoulou E, Loubière LS, Heuer H, Trajkovic-Arsic M, Darras VM, Visser TJ, Lash GE, Whitley GS, McCabe CJ, Franklyn JA, Kilby MD, Chan SY.

PLoS One. 2013 Jun 12;8(6):e65402. doi: 10.1371/journal.pone.0065402. Print 2013.


MCT8-Specific Thyroid Hormone Cell-Membrane Transporter Deficiency.

Dumitrescu AM, Fu J, Dempsey MA, Refetoff S.

In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Ledbetter N, Mefford HC, Smith RJH, Stephens K, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2017.
2010 Mar 9 [updated 2013 Apr 11].


MCT8 Deficiency in Male Mice Mitigates the Phenotypic Abnormalities Associated With the Absence of a Functional Type 3 Deiodinase.

Stohn JP, Martinez ME, Matoin K, Morte B, Bernal J, Galton VA, St Germain D, Hernandez A.

Endocrinology. 2016 Aug;157(8):3266-77. doi: 10.1210/en.2016-1162. Epub 2016 Jun 2.


Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.

Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, Heuer H.

J Clin Invest. 2014 May;124(5):1987-99. Epub 2014 Apr 1.


Increased oxidative metabolism and neurotransmitter cycling in the brain of mice lacking the thyroid hormone transporter SLC16A2 (MCT8).

Rodrigues TB, Ceballos A, Grijota-Martínez C, Nuñez B, Refetoff S, Cerdán S, Morte B, Bernal J.

PLoS One. 2013 Oct 1;8(10):e74621. doi: 10.1371/journal.pone.0074621. eCollection 2013.

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