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Items: 1 to 20 of 115

1.

High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle.

Caraballo JM, Acosta JC, Cortés MA, Albajar M, Gómez-Casares MT, Batlle-López A, Cuadrado MA, Onaindia A, Bretones G, Llorca J, Piris MA, Colomer D, León J.

Oncotarget. 2014 Jul 15;5(13):4694-708.

2.

SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells.

Bretones G, Acosta JC, Caraballo JM, Ferrándiz N, Gómez-Casares MT, Albajar M, Blanco R, Ruiz P, Hung WC, Albero MP, Perez-Roger I, León J.

J Biol Chem. 2011 Mar 18;286(11):9815-25. doi: 10.1074/jbc.M110.165977. Epub 2011 Jan 18.

3.

Altered expression of Skp2, c-Myc and p27 proteins but not mRNA after H. pylori eradication in chronic gastritis.

Kim SS, Meitner P, Konkin TA, Cho YS, Resnick MB, Moss SF.

Mod Pathol. 2006 Jan;19(1):49-58.

4.

SKP2/P27Kip1 pathway is associated with Advanced Ovarian Cancer in Saudi Patients.

Hafez MM, Alhoshani AR, Al-Hosaini KA, Alsharari SD, Al Rejaie SS, Sayed-Ahmed MM, Al-Shabanah OA.

Asian Pac J Cancer Prev. 2015;16(14):5807-15.

5.

c-myc and skp2 coordinate p27 degradation, vascular smooth muscle proliferation, and neointima formation induced by the parathyroid hormone-related protein.

Sicari BM, Troxell R, Salim F, Tanwir M, Takane KK, Fiaschi-Taesch N.

Endocrinology. 2012 Feb;153(2):861-72. doi: 10.1210/en.2011-1590. Epub 2011 Dec 30.

PMID:
22210745
6.

MYC antagonizes the differentiation induced by imatinib in chronic myeloid leukemia cells through downregulation of p27(KIP1.).

Gómez-Casares MT, García-Alegria E, López-Jorge CE, Ferrándiz N, Blanco R, Alvarez S, Vaqué JP, Bretones G, Caraballo JM, Sánchez-Bailón P, Delgado MD, Martín-Perez J, Cigudosa JC, León J.

Oncogene. 2013 Apr 25;32(17):2239-46. doi: 10.1038/onc.2012.246. Epub 2012 Jun 18.

PMID:
22710719
7.
8.

Divergent expression of cyclin-dependent kinase inhibitors (CKI) and p14ARF/p16 beta in non-Hodgkin's lymphomas and chronic lymphocytic leukemia.

Pabst T, Peters UR, Tinguely M, Schwaller J, Tschan M, Aebi S, Vonlanthen S, Borisch B, Betticher DC, Zimmermann A, Tobler A, Fey MF.

Leuk Lymphoma. 2000 May;37(5-6):639-48.

PMID:
11042528
9.

Korean red ginseng extract induces proliferation to differentiation transition of human acute promyelocytic leukemia cells via MYC-SKP2-CDKN1B axis.

Jo S, Lee H, Kim S, Lee CH, Chung H.

J Ethnopharmacol. 2013 Nov 25;150(2):700-7. doi: 10.1016/j.jep.2013.09.036. Epub 2013 Oct 2.

PMID:
24095829
10.

Cell cycle regulatory proteins and apoptosis in B-cell chronic lymphocytic leukemia.

Wolowiec D, Ciszak L, Kosmaczewska A, Bocko D, Teodorowska R, Frydecka I, Kuliczkowski K.

Haematologica. 2001 Dec;86(12):1296-304.

11.

High intracellular content of cyclin-dependent kinase inhibitor p27(Kip1) in early- and intermediate stage B-cell chronic lymphocytic leukemia lymphocytes predicts rapid progression of the disease.

Wolowiec D, Wojtowicz M, Ciszak L, Kosmaczewska A, Frydecka I, Potoczek S, Urbaniak-Kujda D, Kapelko-Slowik K, Kuliczkowski K.

Eur J Haematol. 2009 Apr;82(4):260-6. doi: 10.1111/j.1600-0609.2008.01196.x. Epub 2009 Jan 6.

PMID:
19187271
12.

SKP2 overexpression is associated with increased serine 10 phosphorylation of p27 (pSer10p27) in triple-negative breast cancer.

Fagan-Solis KD, Pentecost BT, Gozgit JM, Bentley BA, Marconi SM, Otis CN, Anderton DL, Schneider SS, Arcaro KF.

J Cell Physiol. 2014 Sep;229(9):1160-9. doi: 10.1002/jcp.24545.

PMID:
24443386
13.

S-phase kinase-associated protein 2 knockdown blocks colorectal cancer growth via regulation of both p27 and p16 expression.

Xu SY, Wang F, Wei G, Wang B, Yang JY, Huang YZ, Zhang L, Zheng F, Guo LY, Wang JN, Tang JM.

Cancer Gene Ther. 2013 Dec;20(12):690-4. doi: 10.1038/cgt.2013.70. Epub 2013 Dec 13.

PMID:
24336114
14.

Alterations in TP53, cyclin D2, c-Myc, p21WAF1/CIP1 and p27KIP1 expression associated with progression in B-CLL.

Halina A, Artur P, Barbara MK, Joanna S, Anna D.

Folia Histochem Cytobiol. 2010 Dec;48(4):534-41. doi: 10.2478/v10042-010-0048-5.

15.

Regulation of the cell cycle inhibitor p27 and its ubiquitin ligase Skp2 in differentiation of human embryonic stem cells.

Egozi D, Shapira M, Paor G, Ben-Izhak O, Skorecki K, Hershko DD.

FASEB J. 2007 Sep;21(11):2807-17. Epub 2007 May 2.

PMID:
17475922
16.

Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cells.

Bhatt KV, Hu R, Spofford LS, Aplin AE.

Oncogene. 2007 Feb 15;26(7):1056-66. Epub 2006 Aug 21.

PMID:
16924241
17.

The p27-Skp2 axis mediates glucocorticoid-induced cell cycle arrest in T-lymphoma cells.

Kullmann MK, Grubbauer C, Goetsch K, Jäkel H, Podmirseg SR, Trockenbacher A, Ploner C, Cato AC, Weiss C, Kofler R, Hengst L.

Cell Cycle. 2013 Aug 15;12(16):2625-35. doi: 10.4161/cc.25622. Epub 2013 Jul 9.

18.

Early mitotic inhibitor-1, an anaphase-promoting complex/cyclosome inhibitor, can control tumor cell proliferation in hepatocellular carcinoma: correlation with Skp2 stability and degradation of p27(Kip1).

Zhao Y, Tang Q, Ni R, Huang X, Wang Y, Lu C, Shen A, Wang Y, Li C, Yuan Q, Chen H, Cheng C, He S.

Hum Pathol. 2013 Mar;44(3):365-73. doi: 10.1016/j.humpath.2012.03.030. Epub 2012 Sep 17.

PMID:
22995332
19.
20.

Prognostic significance of the cell cycle inhibitor p27Kip1 in chronic B-cell lymphocytic leukemia.

Vrhovac R, Delmer A, Tang R, Marie JP, Zittoun R, Ajchenbaum-Cymbalista F.

Blood. 1998 Jun 15;91(12):4694-700.

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