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A subset of circulating blood mycobacteria-specific CD4 T cells can predict the time to Mycobacterium tuberculosis sputum culture conversion.

Riou C, Gray CM, Lugongolo M, Gwala T, Kiravu A, Deniso P, Stewart-Isherwood L, Omar SV, Grobusch MP, Coetzee G, Conradie F, Ismail N, Kaplan G, Fallows D.

PLoS One. 2014 Jul 21;9(7):e102178. doi: 10.1371/journal.pone.0102178. eCollection 2014.


Biomarkers on patient T cells diagnose active tuberculosis and monitor treatment response.

Adekambi T, Ibegbu CC, Cagle S, Kalokhe AS, Wang YF, Hu Y, Day CL, Ray SM, Rengarajan J.

J Clin Invest. 2015 May;125(5):1827-38. doi: 10.1172/JCI77990. Epub 2015 Mar 30. Erratum in: J Clin Invest. 2015 Sep;125(9):3723.


Tuberculosis Therapy Modifies the Cytokine Profile, Maturation State, and Expression of Inhibitory Molecules on Mycobacterium tuberculosis-Specific CD4+ T-Cells.

Saharia KK, Petrovas C, Ferrando-Martinez S, Leal M, Luque R, Ive P, Luetkemeyer A, Havlir D, Koup RA.

PLoS One. 2016 Jul 1;11(7):e0158262. doi: 10.1371/journal.pone.0158262. eCollection 2016.


Potent immune responses of Ag-specific Vgamma2Vdelta2+ T cells and CD8+ T cells associated with latent stage of Mycobacterium tuberculosis coinfection in HIV-1-infected humans.

Shao L, Zhang W, Zhang S, Chen CY, Jiang W, Xu Y, Meng C, Weng X, Chen ZW.

AIDS. 2008 Nov 12;22(17):2241-50. doi: 10.1097/QAD.0b013e3283117f18.


Incomplete restoration of Mycobacterium tuberculosis-specific-CD4 T cell responses despite antiretroviral therapy.

Hsu DC, Kerr SJ, Thongpaeng P, Iampornsin T, Pett SL, Zaunders JJ, Avihingsanon A, Ubolyam S, Ananworanich J, Kelleher AD, Cooper DA.

J Infect. 2014 Apr;68(4):344-54. doi: 10.1016/j.jinf.2013.11.016. Epub 2013 Dec 8.


The frequencies of IFNγ+IL2+TNFα+ PPD-specific CD4+CD45RO+ T-cells correlate with the magnitude of the QuantiFERON® gold in-tube response in a prospective study of healthy indian adolescents.

Jenum S, Grewal HM, Hokey DA, Kenneth J, Vaz M, Doherty TM, Jahnsen FL; TB Trials Study Group.

PLoS One. 2014 Jul 3;9(7):e101224. doi: 10.1371/journal.pone.0101224. eCollection 2014.


Correlation of mycobacterium tuberculosis specific and non-specific quantitative Th1 T-cell responses with bacillary load in a high burden setting.

Theron G, Peter J, Lenders L, van Zyl-Smit R, Meldau R, Govender U, Dheda K.

PLoS One. 2012;7(5):e37436. doi: 10.1371/journal.pone.0037436. Epub 2012 May 22.


Polyfunctional T-cells and effector memory phenotype are associated with active TB in HIV-infected patients.

Chiacchio T, Petruccioli E, Vanini V, Cuzzi G, Pinnetti C, Sampaolesi A, Antinori A, Girardi E, Goletti D.

J Infect. 2014 Dec;69(6):533-45. doi: 10.1016/j.jinf.2014.06.009. Epub 2014 Jun 26.


Use of HLA-DR*08032/E7 and HLA-DR*0818/E7 tetramers in tracking of epitope-specific CD4+ T cells in active and convalescent tuberculosis patients compared with control donors.

Li Y, Zhu Y, Zhou L, Fang Y, Huang L, Ren L, Peng Y, Li Y, Yang F, Xie D, Tang W, Zhang N, Zhong Q, Lai X.

Immunobiology. 2011 Aug;216(8):947-60. doi: 10.1016/j.imbio.2011.01.003. Epub 2011 Jan 12.


The diagnostic accuracy of urine-based Xpert MTB/RIF in HIV-infected hospitalized patients who are smear-negative or sputum scarce.

Peter JG, Theron G, Muchinga TE, Govender U, Dheda K.

PLoS One. 2012;7(7):e39966. doi: 10.1371/journal.pone.0039966. Epub 2012 Jul 9.


Mycobacterium tuberculosis specific CD8(+) T cells rapidly decline with antituberculosis treatment.

Nyendak MR, Park B, Null MD, Baseke J, Swarbrick G, Mayanja-Kizza H, Nsereko M, Johnson DF, Gitta P, Okwera A, Goldberg S, Bozeman L, Johnson JL, Boom WH, Lewinsohn DA, Lewinsohn DM; Tuberculosis Research Unit and the Tuberculosis Trials Consortium.

PLoS One. 2013 Dec 4;8(12):e81564. doi: 10.1371/journal.pone.0081564. eCollection 2013.


Massive monoclonal expansion of CD4 T-cells specific for a Mycobacterium tuberculosis ESAT-6 peptide.

Hodapp T, Sester U, Mack U, Singh M, Meier T, Wiech E, Fisch P, Ehl S, Sester M.

Eur Respir J. 2012 Jul;40(1):152-60. doi: 10.1183/09031936.00175611. Epub 2012 Jan 20.


Increasing CD4+ T cells specific for tuberculosis correlate with improved clinical immunity after highly active antiretroviral therapy.

Hengel RL, Allende MC, Dewar RL, Metcalf JA, Mican JM, Lane HC.

AIDS Res Hum Retroviruses. 2002 Sep 1;18(13):969-75.


BCG-specific IgG-secreting peripheral plasmablasts as a potential biomarker of active tuberculosis in HIV negative and HIV positive patients.

Ashenafi S, Aderaye G, Zewdie M, Raqib R, Bekele A, Magalhaes I, Lema B, Habtamu M, Rekha RS, Aseffa G, Maeurer M, Aseffa A, Svensson M, Andersson J, Brighenti S.

Thorax. 2013 Mar;68(3):269-76. doi: 10.1136/thoraxjnl-2012-201817. Epub 2012 Aug 24.


Immunological profiles of immune restoration disease presenting as mycobacterial lymphadenitis and cryptococcal meningitis.

Tan DB, Yong YK, Tan HY, Kamarulzaman A, Tan LH, Lim A, James I, French M, Price P.

HIV Med. 2008 May;9(5):307-16. doi: 10.1111/j.1468-1293.2008.00565.x.


Mycobacterium tuberculosis-Specific IL-21+IFN-γ+CD4+ T Cells Are Regulated by IL-12.

Li L, Jiang Y, Lao S, Yang B, Yu S, Zhang Y, Wu C.

PLoS One. 2016 Jan 19;11(1):e0147356. doi: 10.1371/journal.pone.0147356. eCollection 2016.


Recruitment of Mycobacterium tuberculosis specific CD4+ T cells to the site of infection for diagnosis of active tuberculosis.

Nemeth J, Winkler HM, Zwick RH, Rumetshofer R, Schenk P, Burghuber OC, Graninger W, Ramharter M, Winkler S.

J Intern Med. 2009 Jan;265(1):163-8. doi: 10.1111/j.1365-2796.2008.02012.x. Epub 2008 Sep 10.


CD4 cell levels during treatment for tuberculosis (TB) in Ethiopian adults and clinical markers associated with CD4 lymphocytopenia.

Skogmar S, Schön T, Balcha TT, Jemal ZH, Tibesso G, Björk J, Björkman P.

PLoS One. 2013 Dec 16;8(12):e83270. doi: 10.1371/journal.pone.0083270. eCollection 2013.

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