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Peroxisome proliferator-activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP-activated protein kinase.

Zhao X, Petursson F, Viollet B, Lotz M, Terkeltaub R, Liu-Bryan R.

Arthritis Rheumatol. 2014 Nov;66(11):3073-82. doi: 10.1002/art.38791.


Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α.

Wang Y, Zhao X, Lotz M, Terkeltaub R, Liu-Bryan R.

Arthritis Rheumatol. 2015 May;67(8):2141-53. doi: 10.1002/art.39182.


SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex.

Olmos Y, Sánchez-Gómez FJ, Wild B, García-Quintans N, Cabezudo S, Lamas S, Monsalve M.

Antioxid Redox Signal. 2013 Nov 1;19(13):1507-21. doi: 10.1089/ars.2012.4713. Epub 2013 Apr 15.


Fenofibrate improves renal lipotoxicity through activation of AMPK-PGC-1α in db/db mice.

Hong YA, Lim JH, Kim MY, Kim TW, Kim Y, Yang KS, Park HS, Choi SR, Chung S, Kim HW, Kim HW, Choi BS, Chang YS, Park CW.

PLoS One. 2014 May 6;9(5):e96147. doi: 10.1371/journal.pone.0096147. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e105921.


Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes.

Petursson F, Husa M, June R, Lotz M, Terkeltaub R, Liu-Bryan R.

Arthritis Res Ther. 2013 Jul 25;15(4):R77. doi: 10.1186/ar4254.


Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.

Buler M, Aatsinki SM, Skoumal R, Komka Z, Tóth M, Kerkelä R, Georgiadi A, Kersten S, Hakkola J.

J Biol Chem. 2012 Jan 13;287(3):1847-60. doi: 10.1074/jbc.M111.302356. Epub 2011 Nov 23.


Acetylcholine promotes ROS detoxification against hypoxia/reoxygenation-induced oxidative stress through FoxO3a/PGC-1α dependent superoxide dismutase.

Sun L, Zang WJ, Wang H, Zhao M, Yu XJ, He X, Miao Y, Zhou J.

Cell Physiol Biochem. 2014;34(5):1614-25. doi: 10.1159/000366364. Epub 2014 Nov 3. Erratum in: Cell Physiol Biochem. 2015;36(5):2083.


High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARα-FoxO3a-PGC-1α pathway.

Chung HW, Lim JH, Kim MY, Shin SJ, Chung S, Choi BS, Kim HW, Kim YS, Park CW, Chang YS.

Nephrol Dial Transplant. 2012 Jun;27(6):2213-25. doi: 10.1093/ndt/gfr613. Epub 2011 Nov 9.


Curcumin regulates peroxisome proliferator-activated receptor-γ coactivator-1α expression by AMPK pathway in hepatic stellate cells in vitro.

Zhai X, Qiao H, Guan W, Li Z, Cheng Y, Jia X, Zhou Y.

Eur J Pharmacol. 2015 Jan 5;746:56-62. doi: 10.1016/j.ejphar.2014.10.055. Epub 2014 Nov 12.


Mutual dependence of Foxo3a and PGC-1alpha in the induction of oxidative stress genes.

Olmos Y, Valle I, Borniquel S, Tierrez A, Soria E, Lamas S, Monsalve M.

J Biol Chem. 2009 May 22;284(21):14476-84. doi: 10.1074/jbc.M807397200. Epub 2009 Mar 26.


Nitric oxide and AMPK cooperatively regulate PGC-1 in skeletal muscle cells.

Lira VA, Brown DL, Lira AK, Kavazis AN, Soltow QA, Zeanah EH, Criswell DS.

J Physiol. 2010 Sep 15;588(Pt 18):3551-66. doi: 10.1113/jphysiol.2010.194035. Epub 2010 Jul 19.


[Recent advances in the study of AMPK and inflammatory pulmonary disease].

Xuan LL, Hou Q.

Yao Xue Xue Bao. 2014 Aug;49(8):1089-96. Review. Chinese.


Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart.

Yan W, Zhang H, Liu P, Wang H, Liu J, Gao C, Liu Y, Lian K, Yang L, Sun L, Guo Y, Zhang L, Dong L, Lau WB, Gao E, Gao F, Xiong L, Wang H, Qu Y, Tao L.

Basic Res Cardiol. 2013 May;108(3):329. doi: 10.1007/s00395-013-0329-1. Epub 2013 Mar 5.


Evidence for the role of AMPK in regulating PGC-1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue.

Wan Z, Root-McCaig J, Castellani L, Kemp BE, Steinberg GR, Wright DC.

Obesity (Silver Spring). 2014 Mar;22(3):730-8. doi: 10.1002/oby.20605. Epub 2013 Sep 20.


AMPK inhibits myoblast differentiation through a PGC-1alpha-dependent mechanism.

Williamson DL, Butler DC, Alway SE.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E304-14. doi: 10.1152/ajpendo.91007.2008. Epub 2009 Jun 2.


AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle.

Smith BK, Mukai K, Lally JS, Maher AC, Gurd BJ, Heigenhauser GJ, Spriet LL, Holloway GP.

J Physiol. 2013 Mar 15;591(6):1551-61. doi: 10.1113/jphysiol.2012.245944. Epub 2013 Jan 7.


Effect of Exercise Training on Skeletal Muscle SIRT1 and PGC-1α Expression Levels in Rats of Different Age.

Huang CC, Wang T, Tung YT, Lin WT.

Int J Med Sci. 2016 Mar 16;13(4):260-70. doi: 10.7150/ijms.14586. eCollection 2016.

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