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Items: 1 to 20 of 153

1.

Discovery of novel aromatase inhibitors using a homogeneous time-resolved fluorescence assay.

Ji JZ, Lao KJ, Hu J, Pang T, Jiang ZZ, Yuan HL, Miao JS, Chen X, Ning SS, Xiang H, Guo YM, Yan M, Zhang LY.

Acta Pharmacol Sin. 2014 Aug;35(8):1082-92. doi: 10.1038/aps.2014.53. Epub 2014 Jul 21.

2.

Aromatase inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and molecular modeling studies of novel phenothiazine derivatives carrying sulfonamide moiety as hybrid molecules.

Ghorab MM, Alsaid MS, Samir N, Abdel-Latif GA, Soliman AM, Ragab FA, Abou El Ella DA.

Eur J Med Chem. 2017 Jul 7;134:304-315. doi: 10.1016/j.ejmech.2017.04.028. Epub 2017 Apr 15.

PMID:
28427017
3.

Molecular docking and 3D-QSAR-based virtual screening of flavonoids as potential aromatase inhibitors against estrogen-dependent breast cancer.

Awasthi M, Singh S, Pandey VP, Dwivedi UN.

J Biomol Struct Dyn. 2015;33(4):804-19. doi: 10.1080/07391102.2014.912152. Epub 2014 Apr 28.

PMID:
24702656
4.

Analogue based drug design, synthesis, molecular docking and anticancer evaluation of novel chromene sulfonamide hybrids as aromatase inhibitors and apoptosis enhancers.

Ghorab MM, Alsaid MS, Al-Ansary GH, Abdel-Latif GA, Abou El Ella DA.

Eur J Med Chem. 2016 Nov 29;124:946-958. doi: 10.1016/j.ejmech.2016.10.020. Epub 2016 Oct 13.

PMID:
27770735
5.

Anti-tumor effect of Shu-Gan-Liang-Xue decoction in breast cancer is related to the inhibition of aromatase and steroid sulfatase expression.

Zhou N, Han SY, Zhou F, Li PP.

J Ethnopharmacol. 2014 Jul 3;154(3):687-95. doi: 10.1016/j.jep.2014.04.045. Epub 2014 May 6.

PMID:
24809288
6.

New steroidal aromatase inhibitors: suppression of estrogen-dependent breast cancer cell proliferation and induction of cell death.

Cepa M, Correia-da-Silva G, da Silva EJ, Roleira FM, Borges M, Teixeira NA.

BMC Cell Biol. 2008 Jul 24;9:41. doi: 10.1186/1471-2121-9-41.

7.

Lead optimization of COX-2 inhibitor nimesulide analogs to overcome aromatase inhibitor resistance in breast cancer cells.

Su B, Chen S.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6733-5. doi: 10.1016/j.bmcl.2009.09.109. Epub 2009 Oct 3.

8.
9.

Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors.

Ferlin MG, Carta D, Bortolozzi R, Ghodsi R, Chimento A, Pezzi V, Moro S, Hanke N, Hartmann RW, Basso G, Viola G.

J Med Chem. 2013 Oct 10;56(19):7536-51. doi: 10.1021/jm400377z. Epub 2013 Sep 27.

PMID:
24025069
10.

Molecular modeling evaluation of non-steroidal aromatase inhibitors.

Narayana BL, Pran Kishore D, Balakumar C, Rao KV, Kaur R, Rao AR, Murthy JN, Ravikumar M.

Chem Biol Drug Des. 2012 May;79(5):674-82. doi: 10.1111/j.1747-0285.2011.01277.x. Epub 2012 Feb 23.

PMID:
22129073
11.

HPMA copolymer-aminoglutethimide conjugates inhibit aromatase in MCF-7 cell lines.

Greco F, Vicent MJ, Penning NA, Nicholson RI, Duncan R.

J Drug Target. 2005 Sep-Nov;13(8-9):459-70.

PMID:
16332571
12.

Structure-based design of potent aromatase inhibitors by high-throughput docking.

Caporuscio F, Rastelli G, Imbriano C, Del Rio A.

J Med Chem. 2011 Jun 23;54(12):4006-17. doi: 10.1021/jm2000689. Epub 2011 May 23.

PMID:
21604760
13.

Potent aromatase inhibitors and molecular mechanism of inhibitory action.

Kang H, Xiao X, Huang C, Yuan Y, Tang D, Dai X, Zeng X.

Eur J Med Chem. 2018 Jan 1;143:426-437. doi: 10.1016/j.ejmech.2017.11.057. Epub 2017 Nov 22.

PMID:
29202405
14.

Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1.

Prior AM, Yu X, Park EJ, Kondratyuk TP, Lin Y, Pezzuto JM, Sun D.

Bioorg Med Chem Lett. 2017 Dec 15;27(24):5393-5399. doi: 10.1016/j.bmcl.2017.11.010. Epub 2017 Nov 6.

PMID:
29153737
15.

Exploring new chemical functionalities to improve aromatase inhibition of steroids.

Varela CL, Amaral C, Correia-da-Silva G, Costa SC, Carvalho RA, Costa G, Alcaro S, Teixeira NA, Tavares-da-Silva EJ, Roleira FM.

Bioorg Med Chem. 2016 Jun 15;24(12):2823-31. doi: 10.1016/j.bmc.2016.04.056. Epub 2016 Apr 26.

PMID:
27160054
16.

Selective regulation of aromatase expression for drug discovery.

Brueggemeier RW, Su B, Darby MV, Sugimoto Y.

J Steroid Biochem Mol Biol. 2010 Feb 28;118(4-5):207-10. doi: 10.1016/j.jsbmb.2009.11.009. Epub 2009 Dec 1.

17.
18.

A novel anti-tumor inhibitor identified by virtual screen with PLK1 structure and zebrafish assay.

Lu J, Xin S, Meng H, Veldman M, Schoenfeld D, Che C, Yan R, Zhong H, Li S, Lin S.

PLoS One. 2013 Apr 26;8(4):e53317. doi: 10.1371/journal.pone.0053317. Print 2013.

19.

Efficacy and mechanism of action of Proellex, an antiprogestin in aromatase overexpressing and Letrozole resistant T47D breast cancer cells.

Gupta A, Mehta R, Alimirah F, Peng X, Murillo G, Wiehle R, Mehta RG.

J Steroid Biochem Mol Biol. 2013 Jan;133:30-42. doi: 10.1016/j.jsbmb.2012.08.004. Epub 2012 Aug 23.

PMID:
22939887
20.

Synthesis, molecular docking, and QSAR study of sulfonamide-based indoles as aromatase inhibitors.

Pingaew R, Mandi P, Prachayasittikul V, Prachayasittikul S, Ruchirawat S, Prachayasittikul V.

Eur J Med Chem. 2018 Jan 1;143:1604-1615. doi: 10.1016/j.ejmech.2017.10.057. Epub 2017 Oct 20.

PMID:
29137864

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