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Items: 1 to 20 of 95

1.

Three-dimensional structure of human γ-secretase.

Lu P, Bai XC, Ma D, Xie T, Yan C, Sun L, Yang G, Zhao Y, Zhou R, Scheres SH, Shi Y.

Nature. 2014 Aug 14;512(7513):166-70. doi: 10.1038/nature13567.

2.

Structural basis of human γ-secretase assembly.

Sun L, Zhao L, Yang G, Yan C, Zhou R, Zhou X, Xie T, Zhao Y, Wu S, Li X, Shi Y.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6003-8. doi: 10.1073/pnas.1506242112.

3.

An atomic structure of human γ-secretase.

Bai XC, Yan C, Yang G, Lu P, Ma D, Sun L, Zhou R, Scheres SH, Shi Y.

Nature. 2015 Sep 10;525(7568):212-7. doi: 10.1038/nature14892.

4.

Crystal structure of the γ-secretase component nicastrin.

Xie T, Yan C, Zhou R, Zhao Y, Sun L, Yang G, Lu P, Ma D, Shi Y.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13349-54. doi: 10.1073/pnas.1414837111.

5.

The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.

Laudon H, Winblad B, Näslund J.

Physiol Behav. 2007 Sep 10;92(1-2):115-20. Review.

PMID:
17588625
6.

Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.

Hansson CA, Frykman S, Farmery MR, Tjernberg LO, Nilsberth C, Pursglove SE, Ito A, Winblad B, Cowburn RF, Thyberg J, Ankarcrona M.

J Biol Chem. 2004 Dec 3;279(49):51654-60.

7.

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution.

Osenkowski P, Li H, Ye W, Li D, Aeschbach L, Fraering PC, Wolfe MS, Selkoe DJ, Li H.

J Mol Biol. 2009 Jan 16;385(2):642-52. doi: 10.1016/j.jmb.2008.10.078.

8.
9.

Structure of the transmembrane domain of human nicastrin-a component of γ-secretase.

Li Y, Liew LS, Li Q, Kang C.

Sci Rep. 2016 Jan 18;6:19522. doi: 10.1038/srep19522.

10.
11.
12.

A reporter for amyloid precursor protein gamma-secretase activity in Drosophila.

Guo M, Hong EJ, Fernandes J, Zipursky SL, Hay BA.

Hum Mol Genet. 2003 Oct 15;12(20):2669-78.

13.

Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy.

Renzi F, Zhang X, Rice WJ, Torres-Arancivia C, Gomez-Llorente Y, Diaz R, Ahn K, Yu C, Li YM, Sisodia SS, Ubarretxena-Belandia I.

J Biol Chem. 2011 Jun 17;286(24):21440-9. doi: 10.1074/jbc.M110.193326.

14.

Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.

Zhang L, Lee J, Song L, Sun X, Shen J, Terracina G, Parker EM.

Biochemistry. 2005 Mar 22;44(11):4450-7.

PMID:
15766275
15.

Assembly, trafficking and function of gamma-secretase.

Kaether C, Haass C, Steiner H.

Neurodegener Dis. 2006;3(4-5):275-83. Review.

PMID:
17047368
16.

Three-dimensional structure of the gamma-secretase complex.

Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Tomita T, Sato C.

Biochem Biophys Res Commun. 2006 May 5;343(2):525-34. Erratum in: Biochem Biophys Res Commun. 2006 Jun 23;345(1):543. Iwastubo, Takeshi [corrected to Iwatsubo, Takeshi].

PMID:
16546128
17.

Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.

Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.

Neurobiol Dis. 2007 Feb;25(2):291-6.

PMID:
17071095
18.

The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity.

Bergman A, Laudon H, Winblad B, Lundkvist J, Näslund J.

J Biol Chem. 2004 Oct 29;279(44):45564-72.

19.

Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.

Zhang YW, Luo WJ, Wang H, Lin P, Vetrivel KS, Liao F, Li F, Wong PC, Farquhar MG, Thinakaran G, Xu H.

J Biol Chem. 2005 Apr 29;280(17):17020-6.

20.

Gamma-secretase: structure, function, and modulation for Alzheimer's disease.

Wolfe MS.

Curr Top Med Chem. 2008;8(1):2-8. Review.

PMID:
18220927
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