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Expression of focal adhesion kinase in uveal melanoma and the effects of Hsp90 inhibition by 17-AAG.

Faingold D, Filho VB, Fernandes B, Jagan L, de Barros AM Jr, Orellana ME, Antecka E, Burnier MN Jr.

Pathol Res Pract. 2014 Nov;210(11):739-45. doi: 10.1016/j.prp.2014.06.023. Epub 2014 Jul 1.


17-AAG and 17-DMAG-induced inhibition of cell proliferation through B-Raf downregulation in WT B-Raf-expressing uveal melanoma cell lines.

Babchia N, Calipel A, Mouriaux F, Faussat AM, Mascarelli F.

Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2348-56. doi: 10.1167/iovs.07-1305. Epub 2008 Feb 15.


Immune expression and inhibition of heat shock protein 90 in uveal melanoma.

Faingold D, Marshall JC, Antecka E, Di Cesare S, Odashiro AN, Bakalian S, Fernandes BF, Burnier MN Jr.

Clin Cancer Res. 2008 Feb 1;14(3):847-55. doi: 10.1158/1078-0432.CCR-07-0926.


Heat Shock Protein 90 is overexpressed in high-risk myelodysplastic syndromes and associated with higher expression and activation of Focal Adhesion Kinase.

Flandrin-Gresta P, Solly F, Aanei CM, Cornillon J, Tavernier E, Nadal N, Morteux F, Guyotat D, Wattel E, Campos L.

Oncotarget. 2012 Oct;3(10):1158-68.


The HSP90 inhibitor 17-AAG synergizes with doxorubicin and U0126 in anaplastic large cell lymphoma irrespective of ALK expression.

Georgakis GV, Li Y, Rassidakis GZ, Medeiros LJ, Younes A.

Exp Hematol. 2006 Dec;34(12):1670-9.


Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in squamous cell carcinoma of the larynx.

Aronsohn MS, Brown HM, Hauptman G, Kornberg LJ.

Laryngoscope. 2003 Nov;113(11):1944-8.


HSP90 inhibition induces cytotoxicity via down-regulation of Rad51 expression and DNA repair capacity in non-small cell lung cancer cells.

Ko JC, Chen HJ, Huang YC, Tseng SC, Weng SH, Wo TY, Huang YJ, Chiu HC, Tsai MS, Chiou RY, Lin YW.

Regul Toxicol Pharmacol. 2012 Dec;64(3):415-24. doi: 10.1016/j.yrtph.2012.10.003. Epub 2012 Oct 13.


NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG.

Kasai S, Arakawa N, Okubo A, Shigeeda W, Yasuhira S, Masuda T, Akasaka T, Shibazaki M, Maesawa C.

PLoS One. 2016 Apr 5;11(4):e0153181. doi: 10.1371/journal.pone.0153181. eCollection 2016.


Targeting focal adhesion kinase with dominant-negative FRNK or Hsp90 inhibitor 17-DMAG suppresses tumor growth and metastasis of SiHa cervical xenografts.

Schwock J, Dhani N, Cao MP, Zheng J, Clarkson R, Radulovich N, Navab R, Horn LC, Hedley DW.

Cancer Res. 2009 Jun 1;69(11):4750-9. doi: 10.1158/0008-5472.CAN-09-0454. Epub 2009 May 19.


Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition.

Beloueche-Babari M, Arunan V, Jackson LE, Perusinghe N, Sharp SY, Workman P, Leach MO.

Oncotarget. 2010 Jul;1(3):185-97.


Acquired resistance to HSP90 inhibitor 17-AAG and increased metastatic potential are associated with MUC1 expression in colon carcinoma cells.

Liu X, Ban LL, Luo G, Li ZY, Li YF, Zhou YC, Wang XC, Jin CG, Ye JG, Ma DD, Xie Q, Huang YG.

Anticancer Drugs. 2016 Jun;27(5):417-26. doi: 10.1097/CAD.0000000000000347.


Expression of the metastasis suppressor gene KISS1 in uveal melanoma.

Martins CM, Fernandes BF, Antecka E, Di Cesare S, Mansure JJ, Marshall JC, Burnier MN Jr.

Eye (Lond). 2008 May;22(5):707-11. doi: 10.1038/sj.eye.6703090. Epub 2008 Jan 25.


Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel.

Sawai A, Chandarlapaty S, Greulich H, Gonen M, Ye Q, Arteaga CL, Sellers W, Rosen N, Solit DB.

Cancer Res. 2008 Jan 15;68(2):589-96. doi: 10.1158/0008-5472.CAN-07-1570.


Anti-proliferative activity of heat shock protein (Hsp) 90 inhibitors via beta-catenin/TCF7L2 pathway in adult T cell leukemia cells.

Kurashina R, Ohyashiki JH, Kobayashi C, Hamamura R, Zhang Y, Hirano T, Ohyashiki K.

Cancer Lett. 2009 Oct 18;284(1):62-70. doi: 10.1016/j.canlet.2009.04.012. Epub 2009 May 21.


Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation.

Krishnamoorthy GP, Guida T, Alfano L, Avilla E, Santoro M, Carlomagno F, Melillo RM.

J Biol Chem. 2013 Jun 14;288(24):17481-94. doi: 10.1074/jbc.M112.439422. Epub 2013 Apr 29.


Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis.

Sanderson S, Valenti M, Gowan S, Patterson L, Ahmad Z, Workman P, Eccles SA.

Mol Cancer Ther. 2006 Mar;5(3):522-32.


HSP90 inhibition results in apoptosis of Philadelphia acute lymphoblastic leukaemia cells: an attractive prospect of new targeted agents.

Tavernier E, Flandrin-Gresta P, Solly F, Rigollet L, Cornillon J, Augeul-Meunier K, Stephan JL, Montmartin A, Viallet A, Guyotat D, Campos L.

J Cancer Res Clin Oncol. 2012 Oct;138(10):1753-8. Epub 2012 Jun 17.


Immunomagnetic isolation and in vitro expansion of human uveal melanoma cell lines.

Cools-Lartigue JJ, McCauley CS, Marshall JC, Di Cesare S, Gregoire F, Antecka E, Logan P, Burnier MN.

Mol Vis. 2008 Jan 10;14:50-5.

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