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The combined loss of Gads and CD127 reveals a novel function of Gads prior to TCRβ expression.

Xiong J, Parker BL, Yankee TM.

Immunol Res. 2014 Oct;60(1):77-84. doi: 10.1007/s12026-014-8556-6.


Gads-/- mice reveal functionally distinct subsets of TCRbeta+ CD4-CD8- double-negative thymocytes.

Zeng L, Dalheimer SL, Yankee TM.

J Immunol. 2007 Jul 15;179(2):1013-21.


Interleukin-7 supports survival of T-cell receptor-β-expressing CD4(-) CD8(-) double-negative thymocytes.

Xiong J, Parker BL, Dalheimer SL, Yankee TM.

Immunology. 2013 Apr;138(4):382-91. doi: 10.1111/imm.12050.


Gads-deficient thymocytes are blocked at the transitional single positive CD4+ stage.

Dalheimer SL, Zeng L, Draves KE, Hassaballa A, Jiwa NN, Parrish TD, Clark EA, Yankee TM.

Eur J Immunol. 2009 May;39(5):1395-404. doi: 10.1002/eji.200838692. Erratum in: Eur J Immunol. 2014 Dec;44(12):3768.


Gads regulates the expansion phase of CD8+ T cell-mediated immunity.

Zhang EY, Parker BL, Yankee TM.

J Immunol. 2011 Apr 15;186(8):4579-89. doi: 10.4049/jimmunol.1001604. Epub 2011 Mar 16.


Expression and function of the adaptor protein Gads in murine B cells.

Yankee TM, Draves KE, Clark EA.

Eur J Immunol. 2005 Apr;35(4):1184-92.


Requirement for the SLP-76 adaptor GADS in T cell development.

Yoder J, Pham C, Iizuka YM, Kanagawa O, Liu SK, McGlade J, Cheng AM.

Science. 2001 Mar 9;291(5510):1987-91.


IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells.

Faller E, Kakal J, Kumar R, Macpherson P.

Int Immunol. 2009 Mar;21(3):203-16. doi: 10.1093/intimm/dxn140. Epub 2009 Jan 15.


HIV infection of thymocytes inhibits IL-7 activity without altering CD127 expression.

Young CD, Angel JB.

Retrovirology. 2011 Sep 16;8:72. doi: 10.1186/1742-4690-8-72.


Human bone marrow contains a subset of quiescent early memory CD8(+) T cells characterized by high CD127 expression and efflux capacity.

Kudernatsch RF, Letsch A, Guerreiro M, Löbel M, Bauer S, Volk HD, Scheibenbogen C.

Eur J Immunol. 2014 Dec;44(12):3532-42. doi: 10.1002/eji.201344180. Epub 2014 Oct 27.


Selective impairment of FcepsilonRI-mediated allergic reaction in Gads-deficient mice.

Yamasaki S, Takase-Utsugi M, Ishikawa E, Sakuma M, Nishida K, Saito T, Kanagawa O.

Int Immunol. 2008 Oct;20(10):1289-97. doi: 10.1093/intimm/dxn085. Epub 2008 Jul 29.


Interleukin-4 downregulates CD127 expression and activity on human thymocytes and mature CD8+ T cells.

Crawley AM, Vranjkovic A, Young C, Angel JB.

Eur J Immunol. 2010 May;40(5):1396-407. doi: 10.1002/eji.200940093.


The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.

Sullivan SA, Zhu M, Bao S, Lewis CA, Ou-Yang CW, Zhang W.

J Immunol. 2014 Mar 15;192(6):2865-74. doi: 10.4049/jimmunol.1302493. Epub 2014 Feb 12.


GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells.

Bilal MY, Zhang EY, Dinkel B, Hardy D, Yankee TM, Houtman JC.

Cell Signal. 2015 Apr;27(4):841-50. doi: 10.1016/j.cellsig.2015.01.012. Epub 2015 Jan 28.


Increased CD127 expression on activated FOXP3+CD4+ regulatory T cells.

Simonetta F, Chiali A, Cordier C, Urrutia A, Girault I, Bloquet S, Tanchot C, Bourgeois C.

Eur J Immunol. 2010 Sep;40(9):2528-38. doi: 10.1002/eji.201040531.


The orphan adapter protein SLY1 as a novel anti-apoptotic protein required for thymocyte development.

Reis B, Pfeffer K, Beer-Hammer S.

BMC Immunol. 2009 Jul 15;10:38. doi: 10.1186/1471-2172-10-38.


IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection.

Boudil A, Matei IR, Shih HY, Bogdanoski G, Yuan JS, Chang SG, Montpellier B, Kowalski PE, Voisin V, Bashir S, Bader GD, Krangel MS, Guidos CJ.

Nat Immunol. 2015 Apr;16(4):397-405. doi: 10.1038/ni.3122. Epub 2015 Mar 2.


Regulation of T cell receptor (TCR) beta gene expression by CD3 complex signaling in immature thymocytes: implications for TCRbeta allelic exclusion.

Biro J, Würch A, Potocnik AJ, Falk I, Mossmann H, Eichmann K.

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3882-7.


The influence of HIV on CD127 expression and its potential implications for IL-7 therapy.

Crawley AM, Angel JB.

Semin Immunol. 2012 Jun;24(3):231-40. doi: 10.1016/j.smim.2012.02.006. Epub 2012 Mar 14. Review.


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