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Items: 1 to 20 of 119

1.

Genetic approaches to generate hyper-producing strains of goadsporin: the relationships between productivity and gene duplication in secondary metabolite biosynthesis.

Haginaka K, Asamizu S, Ozaki T, Igarashi Y, Furumai T, Onaka H.

Biosci Biotechnol Biochem. 2014;78(3):394-9. doi: 10.1080/09168451.2014.885824. Epub 2014 Apr 16.

PMID:
25036825
2.

Cloning and characterization of the goadsporin biosynthetic gene cluster from Streptomyces sp. TP-A0584.

Onaka H, Nakaho M, Hayashi K, Igarashi Y, Furumai T.

Microbiology. 2005 Dec;151(Pt 12):3923-33.

PMID:
16339937
3.

Novel antibiotic screening methods to awaken silent or cryptic secondary metabolic pathways in actinomycetes.

Onaka H.

J Antibiot (Tokyo). 2017 Jul;70(8):865-870. doi: 10.1038/ja.2017.51. Epub 2017 Apr 26. Review.

PMID:
28442735
4.
5.

Challenges in the Heterologous Production of Antibiotics in Streptomyces.

Bekiesch P, Basitta P, Apel AK.

Arch Pharm (Weinheim). 2016 Aug;349(8):594-601. doi: 10.1002/ardp.201600058. Epub 2016 Jun 3. Review.

PMID:
27258165
6.

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism.

Komatsu M, Uchiyama T, Omura S, Cane DE, Ikeda H.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2646-51. doi: 10.1073/pnas.0914833107. Epub 2010 Jan 25.

7.
8.

Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites.

Komatsu M, Komatsu K, Koiwai H, Yamada Y, Kozone I, Izumikawa M, Hashimoto J, Takagi M, Omura S, Shin-ya K, Cane DE, Ikeda H.

ACS Synth Biol. 2013 Jul 19;2(7):384-96. doi: 10.1021/sb3001003. Epub 2013 Jan 17.

9.

Identification and characterization of wblA-dependent tmcT regulation during tautomycetin biosynthesis in Streptomyces sp. CK4412.

Nah JH, Park SH, Yoon HM, Choi SS, Lee CH, Kim ES.

Biotechnol Adv. 2012 Jan-Feb;30(1):202-9. doi: 10.1016/j.biotechadv.2011.05.004. Epub 2011 May 20. Erratum in: Biotechnol Adv. 2012 Nov;30(6):1750.

PMID:
21624452
10.

Precise cloning and tandem integration of large polyketide biosynthetic gene cluster using Streptomyces artificial chromosome system.

Nah HJ, Woo MW, Choi SS, Kim ES.

Microb Cell Fact. 2015 Sep 16;14:140. doi: 10.1186/s12934-015-0325-2.

11.

Production of a Novel Amide-Containing Polyene by Activating a Cryptic Biosynthetic Gene Cluster in Streptomyces sp. MSC090213JE08.

Du D, Katsuyama Y, Onaka H, Fujie M, Satoh N, Shin-Ya K, Ohnishi Y.

Chembiochem. 2016 Aug 3;17(15):1464-71. doi: 10.1002/cbic.201600167. Epub 2016 Jun 17.

PMID:
27311327
12.

Insights into the Biosynthesis of Dehydroalanines in Goadsporin.

Ozaki T, Kurokawa Y, Hayashi S, Oku N, Asamizu S, Igarashi Y, Onaka H.

Chembiochem. 2016 Feb 2;17(3):218-23. doi: 10.1002/cbic.201500541. Epub 2016 Jan 8.

PMID:
26630235
13.

Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074.

Olano C, García I, González A, Rodriguez M, Rozas D, Rubio J, Sánchez-Hidalgo M, Braña AF, Méndez C, Salas JA.

Microb Biotechnol. 2014 May;7(3):242-56. doi: 10.1111/1751-7915.12116. Epub 2014 Mar 4.

14.

Activation and silencing of secondary metabolites in Streptomyces albus and Streptomyces lividans after transformation with cosmids containing the thienamycin gene cluster from Streptomyces cattleya.

Braña AF, Rodríguez M, Pahari P, Rohr J, García LA, Blanco G.

Arch Microbiol. 2014 May;196(5):345-55. doi: 10.1007/s00203-014-0977-z. Epub 2014 Mar 15.

PMID:
24633227
15.

Waking up Streptomyces secondary metabolism by constitutive expression of activators or genetic disruption of repressors.

Aigle B, Corre C.

Methods Enzymol. 2012;517:343-66. doi: 10.1016/B978-0-12-404634-4.00017-6.

PMID:
23084947
16.

Genomic insights into the evolution of hybrid isoprenoid biosynthetic gene clusters in the MAR4 marine streptomycete clade.

Gallagher KA, Jensen PR.

BMC Genomics. 2015 Nov 17;16:960. doi: 10.1186/s12864-015-2110-3.

17.

FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis.

Goranovič D, Blažič M, Magdevska V, Horvat J, Kuščer E, Polak T, Santos-Aberturas J, Martínez-Castro M, Barreiro C, Mrak P, Kopitar G, Kosec G, Fujs S, Martín JF, Petković H.

BMC Microbiol. 2012 Oct 19;12:238. doi: 10.1186/1471-2180-12-238.

18.

Rapid cloning and heterologous expression of the meridamycin biosynthetic gene cluster using a versatile Escherichia coli-streptomyces artificial chromosome vector, pSBAC.

Liu H, Jiang H, Haltli B, Kulowski K, Muszynska E, Feng X, Summers M, Young M, Graziani E, Koehn F, Carter GT, He M.

J Nat Prod. 2009 Mar 27;72(3):389-95. doi: 10.1021/np8006149.

PMID:
19191550
19.

Genome Mining of Streptomyces sp. Tü 6176: Characterization of the Nataxazole Biosynthesis Pathway.

Cano-Prieto C, García-Salcedo R, Sánchez-Hidalgo M, Braña AF, Fiedler HP, Méndez C, Salas JA, Olano C.

Chembiochem. 2015 Jul 6;16(10):1461-73. doi: 10.1002/cbic.201500153. Epub 2015 May 26.

PMID:
25892546
20.

Hierarchical control of virginiamycin production in Streptomyces virginiae by three pathway-specific regulators: VmsS, VmsT and VmsR.

Pulsawat N, Kitani S, Fukushima E, Nihira T.

Microbiology. 2009 Apr;155(Pt 4):1250-9. doi: 10.1099/mic.0.022467-0.

PMID:
19332826

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