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Items: 1 to 20 of 130

1.

The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions.

Backus KM, Dolan MA, Barry CS, Joe M, McPhie P, Boshoff HI, Lowary TL, Davis BG, Barry CE 3rd.

J Biol Chem. 2014 Sep 5;289(36):25041-53. doi: 10.1074/jbc.M114.581579. Epub 2014 Jul 14.

2.

The mycolyltransferase 85A, a putative drug target of Mycobacterium tuberculosis: development of a novel assay and quantification of glycolipid-status of the mycobacterial cell wall.

Elamin AA, Stehr M, Oehlmann W, Singh M.

J Microbiol Methods. 2009 Dec;79(3):358-63. doi: 10.1016/j.mimet.2009.10.010. Epub 2009 Oct 24.

PMID:
19857528
3.

The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha/beta hydrolases.

Wilson RA, Maughan WN, Kremer L, Besra GS, Fütterer K.

J Mol Biol. 2004 Jan 9;335(2):519-30.

PMID:
14672660
5.

Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity.

Ronning DR, Vissa V, Besra GS, Belisle JT, Sacchettini JC.

J Biol Chem. 2004 Aug 27;279(35):36771-7. Epub 2004 Jun 10.

6.

SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.

Tahlan K, Wilson R, Kastrinsky DB, Arora K, Nair V, Fischer E, Barnes SW, Walker JR, Alland D, Barry CE 3rd, Boshoff HI.

Antimicrob Agents Chemother. 2012 Apr;56(4):1797-809. doi: 10.1128/AAC.05708-11. Epub 2012 Jan 17.

8.

Acetylation of trehalose mycolates is required for efficient MmpL-mediated membrane transport in Corynebacterineae.

Yamaryo-Botte Y, Rainczuk AK, Lea-Smith DJ, Brammananth R, van der Peet PL, Meikle P, Ralton JE, Rupasinghe TW, Williams SJ, Coppel RL, Crellin PK, McConville MJ.

ACS Chem Biol. 2015 Mar 20;10(3):734-46. doi: 10.1021/cb5007689. Epub 2014 Dec 8.

PMID:
25427102
9.

Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines.

Ronning DR, Klabunde T, Besra GS, Vissa VD, Belisle JT, Sacchettini JC.

Nat Struct Biol. 2000 Feb;7(2):141-6.

PMID:
10655617
10.
11.

Computational screening for new inhibitors of M. tuberculosis mycolyltransferases antigen 85 group of proteins as potential drug targets.

Gahoi S, Mandal RS, Ivanisenko N, Shrivastava P, Jain S, Singh AK, Raghunandanan MV, Kanchan S, Taneja B, Mandal C, Ivanisenko VA, Kumar A, Kumar R; Open Source Drug Discovery Consortium., Ramachandran S.

J Biomol Struct Dyn. 2013;31(1):30-43. doi: 10.1080/07391102.2012.691343. Epub 2012 Jul 18.

PMID:
22804492
12.
13.

Design, synthesis, and X-ray analysis of a glycoconjugate bound to Mycobacterium tuberculosis antigen 85C.

Ibrahim DA, Boucau J, Lajiness DH, Veleti SK, Trabbic KR, Adams SS, Ronning DR, Sucheck SJ.

Bioconjug Chem. 2012 Dec 19;23(12):2403-16. doi: 10.1021/bc3004342. Epub 2012 Dec 10.

14.

Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis.

Belisle JT, Vissa VD, Sievert T, Takayama K, Brennan PJ, Besra GS.

Science. 1997 May 30;276(5317):1420-2.

15.

Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis.

Takayama K, Wang C, Besra GS.

Clin Microbiol Rev. 2005 Jan;18(1):81-101. Review.

16.

Functional insights from a comparative study on the dynamics of Antigen85 proteins and MPT51 from Mycobacterium tuberculosis.

Sundar S, Annaraj D, Selvan A, Biswas PG, Vijayakumaran R, Anishetty S.

J Mol Model. 2015 Dec;21(12):310. doi: 10.1007/s00894-015-2853-4. Epub 2015 Nov 12.

PMID:
26564147
17.

The Mycobacterium tuberculosis Ag85A is a novel diacylglycerol acyltransferase involved in lipid body formation.

Elamin AA, Stehr M, Spallek R, Rohde M, Singh M.

Mol Microbiol. 2011 Sep;81(6):1577-92. doi: 10.1111/j.1365-2958.2011.07792.x. Epub 2011 Aug 23.

18.

Another brick in the wall.

Tonge PJ.

Nat Struct Biol. 2000 Feb;7(2):94-6.

PMID:
10655605
19.

Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis.

Kalscheuer R, Weinrick B, Veeraraghavan U, Besra GS, Jacobs WR Jr.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21761-6. doi: 10.1073/pnas.1014642108. Epub 2010 Nov 30.

20.

Inactivation of the Mycobacterium tuberculosis antigen 85 complex by covalent, allosteric inhibitors.

Favrot L, Lajiness DH, Ronning DR.

J Biol Chem. 2014 Sep 5;289(36):25031-40. doi: 10.1074/jbc.M114.582445. Epub 2014 Jul 14.

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