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The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA.

Tan D, Zhou M, Kiledjian M, Tong L.

Nat Struct Mol Biol. 2014 Aug;21(8):679-85. doi: 10.1038/nsmb.2857. Epub 2014 Jul 13.


Structure of human Roquin-2 and its complex with constitutive-decay element RNA.

Sakurai S, Ohto U, Shimizu T.

Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):1048-54. doi: 10.1107/S2053230X15011887. Epub 2015 Jul 29.


Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.

Schlundt A, Heinz GA, Janowski R, Geerlof A, Stehle R, Heissmeyer V, Niessing D, Sattler M.

Nat Struct Mol Biol. 2014 Aug;21(8):671-8. doi: 10.1038/nsmb.2855. Epub 2014 Jul 13.


A Distinct, Sequence-Induced Conformation Is Required for Recognition of the Constitutive Decay Element RNA by Roquin.

Codutti L, Leppek K, Zálešák J, Windeisen V, Masiewicz P, Stoecklin G, Carlomagno T.

Structure. 2015 Aug 4;23(8):1437-47. doi: 10.1016/j.str.2015.06.001. Epub 2015 Jul 9.


Roquin binding to target mRNAs involves a winged helix-turn-helix motif.

Schuetz A, Murakawa Y, Rosenbaum E, Landthaler M, Heinemann U.

Nat Commun. 2014 Dec 11;5:5701. doi: 10.1038/ncomms6701.


Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.

Leppek K, Schott J, Reitter S, Poetz F, Hammond MC, Stoecklin G.

Cell. 2013 May 9;153(4):869-81. doi: 10.1016/j.cell.2013.04.016.


The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs.

Athanasopoulos V, Barker A, Yu D, Tan AH, Srivastava M, Contreras N, Wang J, Lam KP, Brown SH, Goodnow CC, Dixon NE, Leedman PJ, Saint R, Vinuesa CG.

FEBS J. 2010 May;277(9):2109-27. doi: 10.1111/j.1742-4658.2010.07628.x.


Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.

Janowski R, Heinz GA, Schlundt A, Wommelsdorf N, Brenner S, Gruber AR, Blank M, Buch T, Buhmann R, Zavolan M, Niessing D, Heissmeyer V, Sattler M.

Nat Commun. 2016 Mar 24;7:11032. doi: 10.1038/ncomms11032.


RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.

Murakawa Y, Hinz M, Mothes J, Schuetz A, Uhl M, Wyler E, Yasuda T, Mastrobuoni G, Friedel CC, Dölken L, Kempa S, Schmidt-Supprian M, Blüthgen N, Backofen R, Heinemann U, Wolf J, Scheidereit C, Landthaler M.

Nat Commun. 2015 Jul 14;6:7367. doi: 10.1038/ncomms8367.


New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.

Zhang Q, Fan L, Hou F, Dong A, Wang YX, Tong Y.

Sci Rep. 2015 Oct 22;5:15660. doi: 10.1038/srep15660.


Structural basis for recognition of AU-rich element RNA by the HuD protein.

Wang X, Tanaka Hall TM.

Nat Struct Biol. 2001 Feb;8(2):141-5.


Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation.

Pratama A, Ramiscal RR, Silva DG, Das SK, Athanasopoulos V, Fitch J, Botelho NK, Chang PP, Hu X, Hogan JJ, Maña P, Bernal D, Korner H, Yu D, Goodnow CC, Cook MC, Vinuesa CG.

Immunity. 2013 Apr 18;38(4):669-80. doi: 10.1016/j.immuni.2013.01.011. Epub 2013 Apr 11.


Structural basis of the PNRC2-mediated link between mrna surveillance and decapping.

Lai T, Cho H, Liu Z, Bowler MW, Piao S, Parker R, Kim YK, Song H.

Structure. 2012 Dec 5;20(12):2025-37. doi: 10.1016/j.str.2012.09.009. Epub 2012 Oct 18.


Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.

Srivastava M, Duan G, Kershaw NJ, Athanasopoulos V, Yeo JH, Ose T, Hu D, Brown SH, Jergic S, Patel HR, Pratama A, Richards S, Verma A, Jones EY, Heissmeyer V, Preiss T, Dixon NE, Chong MM, Babon JJ, Vinuesa CG.

Nat Commun. 2015 Feb 20;6:6253. doi: 10.1038/ncomms7253.


Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms.

Mino T, Murakawa Y, Fukao A, Vandenbon A, Wessels HH, Ori D, Uehata T, Tartey S, Akira S, Suzuki Y, Vinuesa CG, Ohler U, Standley DM, Landthaler M, Fujiwara T, Takeuchi O.

Cell. 2015 May 21;161(5):1058-73. doi: 10.1016/j.cell.2015.04.029.

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