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Items: 1 to 20 of 108

1.

Stearoyl-CoA desaturase 1 activity is required for autophagosome formation.

Ogasawara Y, Itakura E, Kono N, Mizushima N, Arai H, Nara A, Mizukami T, Yamamoto A.

J Biol Chem. 2014 Aug 22;289(34):23938-50. doi: 10.1074/jbc.M114.591065. Epub 2014 Jul 14.

2.

Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy.

Roongta UV, Pabalan JG, Wang X, Ryseck RP, Fargnoli J, Henley BJ, Yang WP, Zhu J, Madireddi MT, Lawrence RM, Wong TW, Rupnow BA.

Mol Cancer Res. 2011 Nov;9(11):1551-61. doi: 10.1158/1541-7786.MCR-11-0126. Epub 2011 Sep 27.

3.

Ole1, fatty acid desaturase, is required for Atg9 delivery and isolation membrane expansion during autophagy in Saccharomyces cerevisiae.

Ogasawara Y, Kira S, Mukai Y, Noda T, Yamamoto A.

Biol Open. 2017 Jan 15;6(1):35-40. doi: 10.1242/bio.022053.

4.

In vitro and in vivo antitumor activities of T-3764518, a novel and orally available small molecule stearoyl-CoA desaturase 1 inhibitor.

Nishizawa S, Sumi H, Satoh Y, Yamamoto Y, Kitazawa S, Honda K, Araki H, Kakoi K, Imamura K, Sasaki M, Miyahisa I, Satomi Y, Nishigaki R, Hirayama M, Aoyama K, Maezaki H, Hara T.

Eur J Pharmacol. 2017 Jul 15;807:21-31. doi: 10.1016/j.ejphar.2017.03.064. Epub 2017 Apr 22.

PMID:
28442322
5.

Relationship between stearoyl-CoA desaturase 1 gene expression, relative protein abundance, and its fatty acid products in bovine tissues.

Rezamand P, Watts JS, Yavah KM, Mosley EE, Ma L, Corl BA, McGuire MA.

J Dairy Res. 2014 Aug;81(3):333-9. doi: 10.1017/S0022029914000181. Epub 2014 Jun 6.

PMID:
24904960
6.

Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic β-cells.

Janikiewicz J, Hanzelka K, Dziewulska A, Kozinski K, Dobrzyn P, Bernas T, Dobrzyn A.

J Lipid Res. 2015 Oct;56(10):1901-11. doi: 10.1194/jlr.M059980. Epub 2015 Aug 20.

7.

Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells.

Sinha RA, Singh BK, Zhou J, Xie S, Farah BL, Lesmana R, Ohba K, Tripathi M, Ghosh S, Hollenberg AN, Yen PM.

Autophagy. 2017 Jan 2;13(1):169-186. doi: 10.1080/15548627.2016.1235123. Epub 2016 Nov 15.

8.

Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase.

Kato H, Sakaki K, Mihara K.

J Cell Sci. 2006 Jun 1;119(Pt 11):2342-53.

9.

Stearoyl-CoA desaturase-1 (SCD1) augments saturated fatty acid-induced lipid accumulation and inhibits apoptosis in cardiac myocytes.

Matsui H, Yokoyama T, Sekiguchi K, Iijima D, Sunaga H, Maniwa M, Ueno M, Iso T, Arai M, Kurabayashi M.

PLoS One. 2012;7(3):e33283. doi: 10.1371/journal.pone.0033283. Epub 2012 Mar 8.

10.

Membrane topology of mouse stearoyl-CoA desaturase 1.

Man WC, Miyazaki M, Chu K, Ntambi JM.

J Biol Chem. 2006 Jan 13;281(2):1251-60. Epub 2005 Nov 7.

11.
12.

X-ray structure of a mammalian stearoyl-CoA desaturase.

Bai Y, McCoy JG, Levin EJ, Sobrado P, Rajashankar KR, Fox BG, Zhou M.

Nature. 2015 Aug 13;524(7564):252-6. doi: 10.1038/nature14549. Epub 2015 Jun 22.

13.

Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates.

Wang J, Yu L, Schmidt RE, Su C, Huang X, Gould K, Cao G.

Biochem Biophys Res Commun. 2005 Jul 8;332(3):735-42.

PMID:
15907797
14.

Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1.

Jiang G, Li Z, Liu F, Ellsworth K, Dallas-Yang Q, Wu M, Ronan J, Esau C, Murphy C, Szalkowski D, Bergeron R, Doebber T, Zhang BB.

J Clin Invest. 2005 Apr;115(4):1030-8. Epub 2005 Mar 10. Erratum in: J Clin Invest. 2005 Aug;115(8):2297.

15.
16.

Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer.

Luyimbazi D, Akcakanat A, McAuliffe PF, Zhang L, Singh G, Gonzalez-Angulo AM, Chen H, Do KA, Zheng Y, Hung MC, Mills GB, Meric-Bernstam F.

Mol Cancer Ther. 2010 Oct;9(10):2770-84. doi: 10.1158/1535-7163.MCT-09-0980. Epub 2010 Sep 28.

17.

Development of a high-throughput screening assay for stearoyl-CoA desaturase using rat liver microsomes, deuterium labeled stearoyl-CoA and mass spectrometry.

Soulard P, McLaughlin M, Stevens J, Connolly B, Coli R, Wang L, Moore J, Kuo MS, LaMarr WA, Ozbal CC, Bhat BG.

Anal Chim Acta. 2008 Oct 3;627(1):105-11. doi: 10.1016/j.aca.2008.04.017. Epub 2008 Apr 15.

PMID:
18790133
18.

Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism.

Stamatikos AD, Paton CM.

Am J Physiol Endocrinol Metab. 2013 Oct 1;305(7):E767-75. doi: 10.1152/ajpendo.00268.2013. Epub 2013 Aug 13. Review.

19.

Development of a novel LC/MS method to quantitate cellular stearoyl-CoA desaturase activity.

Dillon R, Greig MJ, Bhat BG.

Anal Chim Acta. 2008 Oct 3;627(1):99-104. doi: 10.1016/j.aca.2008.05.012. Epub 2008 May 15.

PMID:
18790132
20.

Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver.

Dobrzyn A, Dobrzyn P, Miyazaki M, Sampath H, Chu K, Ntambi JM.

J Biol Chem. 2005 Jun 17;280(24):23356-62. Epub 2005 Apr 13.

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