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Items: 1 to 20 of 116

1.

Bicyclic tetrapeptides as potent HDAC inhibitors: effect of aliphatic loop position and hydrophobicity on inhibitory activity.

Islam MN, Islam MS, Hoque MA, Kato T, Nishino N, Ito A, Yoshida M.

Bioorg Med Chem. 2014 Aug 1;22(15):3862-70. doi: 10.1016/j.bmc.2014.06.031. Epub 2014 Jun 26.

PMID:
25022972
2.

Design and synthesis of mono and bicyclic tetrapeptides thioester as potent inhibitor of histone deacetylases.

Hoque MA, Islam MS, Islam MN, Kato T, Nishino N, Ito A, Yoshida M.

Amino Acids. 2014 Oct;46(10):2435-44. doi: 10.1007/s00726-014-1800-5. Epub 2014 Jul 22.

PMID:
25048030
3.

Bicyclic tetrapeptide histone deacetylase inhibitors with methoxymethyl ketone and boronic acid zinc-binding groups.

Islam MN, Islam MS, Hoque MA, Kato T, Nishino N, Ito A, Yoshida M.

Bioorg Chem. 2014 Dec;57:121-6. doi: 10.1016/j.bioorg.2014.10.003. Epub 2014 Oct 22.

PMID:
25462987
4.

Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length.

Islam NM, Kato T, Nishino N, Kim HJ, Ito A, Yoshida M.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):997-9. doi: 10.1016/j.bmcl.2009.12.054. Epub 2009 Dec 21.

PMID:
20045316
5.
6.

Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases.

Hoque MA, Arai T, Nishino N, Kim HJ, Ito A, Yoshida M.

Bioorg Med Chem Lett. 2012 Nov 1;22(21):6770-2. doi: 10.1016/j.bmcl.2012.03.004. Epub 2012 Mar 8.

PMID:
23021104
7.

Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides.

Nishino N, Shivashimpi GM, Soni PB, Bhuiyan MP, Kato T, Maeda S, Nishino TG, Yoshida M.

Bioorg Med Chem. 2008 Jan 1;16(1):437-45. Epub 2007 Sep 15.

PMID:
17900911
8.

Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors.

Hoque MA, Islam MN, Islam MS, Kato T, Nishino N, Ito A, Yoshida M.

Bioorg Med Chem. 2014 Aug 1;22(15):3850-5. doi: 10.1016/j.bmc.2014.06.029. Epub 2014 Jun 25. Retraction in: Bioorg Med Chem. 2015 Aug 1;23(15):5078.

PMID:
24997578
9.

Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.

Jose B, Oniki Y, Kato T, Nishino N, Sumida Y, Yoshida M.

Bioorg Med Chem Lett. 2004 Nov 1;14(21):5343-6.

PMID:
15454224
10.

Synthesis, molecular docking and biological evaluation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition.

Pirali T, Faccio V, Mossetti R, Grolla AA, Di Micco S, Bifulco G, Genazzani AA, Tron GC.

Mol Divers. 2010 Feb;14(1):109-21. doi: 10.1007/s11030-009-9153-9. Epub 2009 May 28.

PMID:
19475493
11.

Synthesis, evaluation and molecular modeling of cyclic tetrapeptide histone deacetylase inhibitors as anticancer agents.

Huang D, Li X, Sun L, Xiu Z, Nishino N.

J Pept Sci. 2012 Apr;18(4):242-51. doi: 10.1002/psc.2392. Epub 2012 Jan 17.

PMID:
22253009
12.

Cyclic tetrapeptides with -SS- bridging between amino acid side chains for potent histone deacetylases' inhibition.

Arai T, Ashraful Hoque M, Nishino N, Kim HJ, Ito A, Yoshida M.

Amino Acids. 2013 Oct;45(4):835-43. doi: 10.1007/s00726-013-1527-8. Epub 2013 Jun 11.

PMID:
23754115
13.

Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes.

Maolanon AR, Kristensen HM, Leman LJ, Ghadiri MR, Olsen CA.

Chembiochem. 2017 Jan 3;18(1):5-49. doi: 10.1002/cbic.201600519. Epub 2016 Dec 8. Review.

PMID:
27748555
14.

Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin.

Furumai R, Komatsu Y, Nishino N, Khochbin S, Yoshida M, Horinouchi S.

Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):87-92.

15.

Discovery of potent HDAC inhibitors based on chlamydocin with inhibitory effects on cell migration.

Wang S, Li X, Wei Y, Xiu Z, Nishino N.

ChemMedChem. 2014 Mar;9(3):627-37. doi: 10.1002/cmdc.201300372. Epub 2013 Nov 27.

PMID:
24285590
16.

Total synthesis of the bicyclic depsipeptide HDAC inhibitors spiruchostatins A and B, 5''-epi-spiruchostatin B, FK228 (FR901228) and preliminary evaluation of their biological activity.

Narita K, Kikuchi T, Watanabe K, Takizawa T, Oguchi T, Kudo K, Matsuhara K, Abe H, Yamori T, Yoshida M, Katoh T.

Chemistry. 2009 Oct 26;15(42):11174-86. doi: 10.1002/chem.200901552.

PMID:
19760730
17.
18.

Structure, histone deacetylase, and antiprotozoal activities of apicidins B and C, congeners of apicidin with proline and valine substitutions.

Singh SB, Zink DL, Liesch JM, Dombrowski AW, Darkin-Rattray SJ, Schmatz DM, Goetz MA.

Org Lett. 2001 Sep 6;3(18):2815-8.

PMID:
11529764
19.

Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand.

Nishino N, Yoshikawa D, Watanabe LA, Kato T, Jose B, Komatsu Y, Sumida Y, Yoshida M.

Bioorg Med Chem Lett. 2004 May 17;14(10):2427-31.

PMID:
15109626
20.

Design and synthesis of a potent histone deacetylase inhibitor.

Liu T, Kapustin G, Etzkorn FA.

J Med Chem. 2007 May 3;50(9):2003-6. Epub 2007 Apr 10.

PMID:
17419603

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