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Items: 1 to 20 of 88

1.

Mechanistic studies on the anticancer activity of 2,4-disubstituted quinazoline derivative.

Su L, Zheng H, Li Z, Qiu J, Chen S, Liu J, Ou TM, Tan JH, Gu LQ, Huang ZS, Li D.

Biochim Biophys Acta. 2014 Oct;1840(10):3123-30. doi: 10.1016/j.bbagen.2014.07.004.

PMID:
25018006
2.

A dihydroindolizino indole derivative selectively stabilizes G-quadruplex DNA and down-regulates c-MYC expression in human cancer cells.

Nagesh N, Raju G, Srinivas R, Ramesh P, Reddy MD, Reddy ChR.

Biochim Biophys Acta. 2015 Jan;1850(1):129-40. doi: 10.1016/j.bbagen.2014.10.004.

PMID:
25452213
3.

Mechanistic studies for the role of cellular nucleic-acid-binding protein (CNBP) in regulation of c-myc transcription.

Chen S, Su L, Qiu J, Xiao N, Lin J, Tan JH, Ou TM, Gu LQ, Huang ZS, Li D.

Biochim Biophys Acta. 2013 Oct;1830(10):4769-77. doi: 10.1016/j.bbagen.2013.06.007.

PMID:
23774591
4.

Design, synthesis and biological evaluation of 4-anilinoquinazoline derivatives as new c-myc G-quadruplex ligands.

Jiang Y, Chen AC, Kuang GT, Wang SK, Ou TM, Tan JH, Li D, Huang ZS.

Eur J Med Chem. 2016 Oct 21;122:264-79. doi: 10.1016/j.ejmech.2016.06.040.

PMID:
27372288
5.

Disubstituted 1,8-dipyrazolcarbazole derivatives as a new type of c-myc G-quadruplex binding ligands.

Chen WJ, Zhou CX, Yao PF, Wang XX, Tan JH, Li D, Ou TM, Gu LQ, Huang ZS.

Bioorg Med Chem. 2012 May 1;20(9):2829-36. doi: 10.1016/j.bmc.2012.03.031.

PMID:
22484007
6.

Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line.

Biliran H Jr, Wang Y, Banerjee S, Xu H, Heng H, Thakur A, Bollig A, Sarkar FH, Liao JD.

Clin Cancer Res. 2005 Aug 15;11(16):6075-86.

7.

Cellular nucleic acid binding protein suppresses tumor cell metastasis and induces tumor cell death by downregulating heterogeneous ribonucleoprotein K in fibrosarcoma cells.

Qiu J, Chen S, Su L, Liu J, Xiao N, Ou TM, Tan JH, Gu LQ, Huang ZS, Li D.

Biochim Biophys Acta. 2014 Jul;1840(7):2244-52. doi: 10.1016/j.bbagen.2014.02.025.

PMID:
24594223
8.

c-myc but not Hif-1α-dependent downregulation of VEGF influences the proliferation and differentiation of HL-60 cells induced by ATRA.

Song G, Li Y, Zhang Z, Ren X, Li H, Zhang W, Wei R, Pan S, Shi L, Bi K, Jiang G.

Oncol Rep. 2013 Jun;29(6):2378-84. doi: 10.3892/or.2013.2395.

PMID:
23588859
9.

Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation.

Seo SK, Jin HO, Woo SH, Kim YS, An S, Lee JH, Hong SI, Lee KH, Choe TB, Park IC.

J Thorac Oncol. 2011 Aug;6(8):1313-9. doi: 10.1097/JTO.0b013e318220caff.

10.

9-N-Substituted berberine derivatives: stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc.

Ma Y, Ou TM, Hou JQ, Lu YJ, Tan JH, Gu LQ, Huang ZS.

Bioorg Med Chem. 2008 Aug 15;16(16):7582-91. doi: 10.1016/j.bmc.2008.07.029.

PMID:
18674916
11.

A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis.

Weinmann L, Wischhusen J, Demma MJ, Naumann U, Roth P, Dasmahapatra B, Weller M.

Cell Death Differ. 2008 Apr;15(4):718-29. doi: 10.1038/sj.cdd.4402301.

12.

Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.

Drygin D, Lin A, Bliesath J, Ho CB, O'Brien SE, Proffitt C, Omori M, Haddach M, Schwaebe MK, Siddiqui-Jain A, Streiner N, Quin JE, Sanij E, Bywater MJ, Hannan RD, Ryckman D, Anderes K, Rice WG.

Cancer Res. 2011 Feb 15;71(4):1418-30. doi: 10.1158/0008-5472.CAN-10-1728.

13.

Inauhzin(c) inactivates c-Myc independently of p53.

Jung JH, Liao JM, Zhang Q, Zeng S, Nguyen D, Hao Q, Zhou X, Cao B, Kim SH, Lu H.

Cancer Biol Ther. 2015;16(3):412-9. doi: 10.1080/15384047.2014.1002698.

14.

Myc down-regulation sensitizes melanoma cells to radiotherapy by inhibiting MLH1 and MSH2 mismatch repair proteins.

Bucci B, D'Agnano I, Amendola D, Citti A, Raza GH, Miceli R, De Paula U, Marchese R, Albini S, Felsani A, Brunetti E, Vecchione A.

Clin Cancer Res. 2005 Apr 1;11(7):2756-67.

15.

Involvement of G-quadruplex structures in regulation of human RET gene expression by small molecules in human medullary thyroid carcinoma TT cells.

Shin YJ, Kumarasamy V, Camacho D, Sun D.

Oncogene. 2015 Mar 5;34(10):1292-9. doi: 10.1038/onc.2014.65.

PMID:
24662821
16.

Novel anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates modulate the expression of p53-MYCN associated micro RNAs in neuroblastoma cells and cause cell cycle arrest and apoptosis.

Ramaiah MJ, Pushpavalli SN, Lavanya A, Bhadra K, Haritha V, Patel N, Tamboli JR, Kamal A, Bhadra U, Pal-Bhadra M.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5699-706. doi: 10.1016/j.bmcl.2013.08.018.

PMID:
23992861
17.

Association of cellular apoptosis with anti-tumor effects of the Chinese herbal complex in endocrine-resistant cancer cell line.

Lian Z, Niwa K, Gao J, Tagami K, Mori H, Tamaya T.

Cancer Detect Prev. 2003;27(2):147-54.

PMID:
12670527
18.

Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA.

Li Z, Tan JH, He JH, Long Y, Ou TM, Li D, Gu LQ, Huang ZS.

Eur J Med Chem. 2012 Jan;47(1):299-311. doi: 10.1016/j.ejmech.2011.10.057.

PMID:
22104971
19.

Ligand activation of peroxisome proliferator-activated receptor gamma induces apoptosis of leukemia cells by down-regulating the c-myc gene expression via blockade of the Tcf-4 activity.

Yamakawa-Karakida N, Sugita K, Inukai T, Goi K, Nakamura M, Uno K, Sato H, Kagami K, Barker N, Nakazawa S.

Cell Death Differ. 2002 May;9(5):513-26.

20.

Induction of apoptosis in human choriocarcinoma cell lines by treatment with 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (vesnarinone).

Isaka K, Fujito A, Sagawa Y, Yudate T, Nishi H, Ito H, Takayama M.

Oncol Rep. 2002 Nov-Dec;9(6):1299-305.

PMID:
12375038

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