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Items: 1 to 20 of 94


Sensitization of radio-resistant prostate cancer cells with a unique cytolethal distending toxin.

Lai CH, Chang CS, Liu HH, Tsai YS, Hsu FM, Yu YL, Lai CK, Gandee L, Pong RC, Hsu HW, Yu L, Saha D, Hsieh JT.

Oncotarget. 2014 Jul 30;5(14):5523-34.


Epothilone B confers radiation dose enhancement in DAB2IP gene knock-down radioresistant prostate cancer cells.

Kong Z, Raghavan P, Xie D, Boike T, Burma S, Chen D, Chakraborty A, Hsieh JT, Saha D.

Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):1210-8. doi: 10.1016/j.ijrobp.2010.06.019.


DAB2IP regulates autophagy in prostate cancer in response to combined treatment of radiation and a DNA-PKcs inhibitor.

Yu L, Tumati V, Tseng SF, Hsu FM, Kim DN, Hong D, Hsieh JT, Jacobs C, Kapur P, Saha D.

Neoplasia. 2012 Dec;14(12):1203-12.


Downregulation of human DAB2IP gene expression in prostate cancer cells results in resistance to ionizing radiation.

Kong Z, Xie D, Boike T, Raghavan P, Burma S, Chen DJ, Habib AA, Chakraborty A, Hsieh JT, Saha D.

Cancer Res. 2010 Apr 1;70(7):2829-39. doi: 10.1158/0008-5472.CAN-09-2919.


Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts.

Fahrer J, Huelsenbeck J, Jaurich H, Dörsam B, Frisan T, Eich M, Roos WP, Kaina B, Fritz G.

DNA Repair (Amst). 2014 Jun;18:31-43. doi: 10.1016/j.dnarep.2014.03.002.


The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect.

Zhang T, Shen Y, Chen Y, Hsieh JT, Kong Z.

Int J Radiat Biol. 2015 Apr;91(4):368-78. doi: 10.3109/09553002.2015.1001531.


Radioprotection and cell cycle arrest of intestinal epithelial cells by darinaparsin, a tumor radiosensitizer.

Tian J, Doi H, Saar M, Santos J, Li X, Peehl DM, Knox SJ.

Int J Radiat Oncol Biol Phys. 2013 Dec 1;87(5):1179-85. doi: 10.1016/j.ijrobp.2013.08.051.


Silibinin Preferentially Radiosensitizes Prostate Cancer by Inhibiting DNA Repair Signaling.

Nambiar DK, Rajamani P, Deep G, Jain AK, Agarwal R, Singh RP.

Mol Cancer Ther. 2015 Dec;14(12):2722-34. doi: 10.1158/1535-7163.MCT-15-0348.


Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal Carcinogenesis.

Graillot V, Dormoy I, Dupuy J, Shay JW, Huc L, Mirey G, Vignard J.

Front Cell Infect Microbiol. 2016 Mar 23;6:34. doi: 10.3389/fcimb.2016.00034.


Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages.

Jinadasa RN, Bloom SE, Weiss RS, Duhamel GE.

Microbiology. 2011 Jul;157(Pt 7):1851-75. doi: 10.1099/mic.0.049536-0. Review.


The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways.

Cortes-Bratti X, Karlsson C, Lagergård T, Thelestam M, Frisan T.

J Biol Chem. 2001 Feb 16;276(7):5296-302.


Molecular Mechanisms and Potential Clinical Applications of Campylobacter jejuni Cytolethal Distending Toxin.

Lai CK, Chen YA, Lin CJ, Lin HJ, Kao MC, Huang MZ, Lin YH, Chiang-Ni C, Chen CJ, Lo UG, Lin LC, Lin H, Hsieh JT, Lai CH.

Front Cell Infect Microbiol. 2016 Feb 9;6:9. doi: 10.3389/fcimb.2016.00009. Review.


The Haemophilus ducreyi cytolethal distending toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA.

Frisan T, Cortes-Bratti X, Chaves-Olarte E, Stenerlöw B, Thelestam M.

Cell Microbiol. 2003 Oct;5(10):695-707.


Role of the ATM-checkpoint kinase 2 pathway in CDT-mediated apoptosis of gingival epithelial cells.

Alaoui-El-Azher M, Mans JJ, Baker HV, Chen C, Progulske-Fox A, Lamont RJ, Handfield M.

PLoS One. 2010 Jul 23;5(7):e11714. doi: 10.1371/journal.pone.0011714.


The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks.

Sert V, Cans C, Tasca C, Bret-Bennis L, Oswald E, Ducommun B, De Rycke J.

Oncogene. 1999 Nov 4;18(46):6296-304.


Cell cycle arrest & apoptosis of epithelial cell line by cytolethal distending toxin positive Campylobacter jejuni.

Jain D, Prasad KN, Sinha S, Vishwakarma AL.

Indian J Med Res. 2009 Apr;129(4):418-23.


Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells.

Gandhi N, Wild AT, Chettiar ST, Aziz K, Kato Y, Gajula RP, Williams RD, Cades JA, Annadanam A, Song D, Zhang Y, Hales RK, Herman JM, Armour E, DeWeese TL, Schaeffer EM, Tran PT.

Cancer Biol Ther. 2013 Apr;14(4):347-56. doi: 10.4161/cbt.23626.


Cholesterol depletion reduces entry of Campylobacter jejuni cytolethal distending toxin and attenuates intoxication of host cells.

Lin CD, Lai CK, Lin YH, Hsieh JT, Sing YT, Chang YC, Chen KC, Wang WC, Su HL, Lai CH.

Infect Immun. 2011 Sep;79(9):3563-75. doi: 10.1128/IAI.05175-11.


Involvement of cholesterol in Campylobacter jejuni cytolethal distending toxin-induced pathogenesis.

Lai CK, Su JC, Lin YH, Chang CS, Feng CL, Lin HJ, Lin CJ, Tseng GC, Liu HH, Hsieh JT, Su HL, Lai CH.

Future Microbiol. 2015;10(4):489-501. doi: 10.2217/fmb.14.119.

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