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Items: 1 to 20 of 112

1.

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway.

Huang R, Sakamuru S, Martin MT, Reif DM, Judson RS, Houck KA, Casey W, Hsieh JH, Shockley KR, Ceger P, Fostel J, Witt KL, Tong W, Rotroff DM, Zhao T, Shinn P, Simeonov A, Dix DJ, Austin CP, Kavlock RJ, Tice RR, Xia M.

Sci Rep. 2014 Jul 11;4:5664. doi: 10.1038/srep05664.

2.

Performance of the BG1Luc ER TA method in a qHTS format.

Ceger P, Allen D, Huang R, Xia M, Casey W.

ALTEX. 2015;32(4):287-96. doi: http://dx.doi.org/10.14573/altex.1505121. Epub 2015 Jun 28. Erratum in: ALTEX. 2016;33(1):79.

3.

Cell-Based High-Throughput Screening for Aromatase Inhibitors in the Tox21 10K Library.

Chen S, Hsieh JH, Huang R, Sakamuru S, Hsin LY, Xia M, Shockley KR, Auerbach S, Kanaya N, Lu H, Svoboda D, Witt KL, Merrick BA, Teng CT, Tice RR.

Toxicol Sci. 2015 Oct;147(2):446-57. doi: 10.1093/toxsci/kfv141. Epub 2015 Jul 3.

4.

Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches.

Zhang L, Sedykh A, Tripathi A, Zhu H, Afantitis A, Mouchlis VD, Melagraki G, Rusyn I, Tropsha A.

Toxicol Appl Pharmacol. 2013 Oct 1;272(1):67-76. doi: 10.1016/j.taap.2013.04.032. Epub 2013 May 23.

5.

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor.

Judson RS, Magpantay FM, Chickarmane V, Haskell C, Tania N, Taylor J, Xia M, Huang R, Rotroff DM, Filer DL, Houck KA, Martin MT, Sipes N, Richard AM, Mansouri K, Setzer RW, Knudsen TB, Crofton KM, Thomas RS.

Toxicol Sci. 2015 Nov;148(1):137-54. doi: 10.1093/toxsci/kfv168. Epub 2015 Aug 13.

6.

Evaluation of ligand selectivity using reporter cell lines stably expressing estrogen receptor alpha or beta.

Escande A, Pillon A, Servant N, Cravedi JP, Larrea F, Muhn P, Nicolas JC, Cavaillès V, Balaguer P.

Biochem Pharmacol. 2006 May 14;71(10):1459-69. Epub 2006 Mar 22.

PMID:
16554039
7.

Identification of compounds by high-content screening that induce cytoplasmic to nuclear localization of a fluorescent estrogen receptor α chimera and exhibit agonist or antagonist activity in vitro.

Dull AB, George AA, Goncharova EI, Evans JR, Wamiru A, Cartner LK, Hager GL, McMahon JB.

J Biomol Screen. 2014 Feb;19(2):242-52. doi: 10.1177/1087057113504136. Epub 2013 Sep 19.

PMID:
24051224
8.

A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells.

Mao C, Patterson NM, Cherian MT, Aninye IO, Zhang C, Montoya JB, Cheng J, Putt KS, Hergenrother PJ, Wilson EM, Nardulli AM, Nordeen SK, Shapiro DJ.

J Biol Chem. 2008 May 9;283(19):12819-30. doi: 10.1074/jbc.M709936200. Epub 2008 Mar 12.

9.

A Screening Assay Cascade to Identify and Characterize Novel Selective Estrogen Receptor Downregulators (SERDs).

Callis R, Rabow A, Tonge M, Bradbury R, Challinor M, Roberts K, Jones K, Walker G.

J Biomol Screen. 2015 Jul;20(6):748-59. doi: 10.1177/1087057115580298. Epub 2015 Apr 7.

PMID:
25851036
10.

Robust array-based coregulator binding assay predicting ERα-agonist potency and generating binding profiles reflecting ligand structure.

Aarts JM, Wang S, Houtman R, van Beuningen RM, Westerink WM, Van De Waart BJ, Rietjens IM, Bovee TF.

Chem Res Toxicol. 2013 Mar 18;26(3):336-46. doi: 10.1021/tx300463b. Epub 2013 Mar 6.

PMID:
23383871
11.

Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses.

Rotroff DM, Martin MT, Dix DJ, Filer DL, Houck KA, Knudsen TB, Sipes NS, Reif DM, Xia M, Huang R, Judson RS.

Environ Sci Technol. 2014;48(15):8706-16. doi: 10.1021/es502676e. Epub 2014 Jul 10.

PMID:
24960280
12.

Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage.

Hsieh JH, Huang R, Lin JA, Sedykh A, Zhao J, Tice RR, Paules RS, Xia M, Auerbach SS.

PLoS One. 2017 May 22;12(5):e0177902. doi: 10.1371/journal.pone.0177902. eCollection 2017. Erratum in: PLoS One. 2017 Jul 7;12 (7):e0181291.

13.

Molecular mechanisms of estrogen action: selective ligands and receptor pharmacology.

Katzenellenbogen BS, Choi I, Delage-Mourroux R, Ediger TR, Martini PG, Montano M, Sun J, Weis K, Katzenellenbogen JA.

J Steroid Biochem Mol Biol. 2000 Nov 30;74(5):279-85. Review.

PMID:
11162936
14.

Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform.

Lynch C, Sakamuru S, Huang R, Stavreva DA, Varticovski L, Hager GL, Judson RS, Houck KA, Kleinstreuer NC, Casey W, Paules RS, Simeonov A, Xia M.

Toxicology. 2017 Jun 15;385:48-58. doi: 10.1016/j.tox.2017.05.001. Epub 2017 May 4.

PMID:
28478275
15.

Extending an in vitro panel for estrogenicity testing: the added value of bioassays for measuring antiandrogenic activities and effects on steroidogenesis.

Wang S, Rijk JC, Besselink HT, Houtman R, Peijnenburg AA, Brouwer A, Rietjens IM, Bovee TF.

Toxicol Sci. 2014 Sep;141(1):78-89. doi: 10.1093/toxsci/kfu103. Epub 2014 Jun 13.

16.

In silico discovery and validation of potent small-molecule inhibitors targeting the activation function 2 site of human oestrogen receptor α.

Singh K, Munuganti RS, Leblanc E, Lin YL, Leung E, Lallous N, Butler M, Cherkasov A, Rennie PS.

Breast Cancer Res. 2015 Feb 25;17:27. doi: 10.1186/s13058-015-0529-8.

17.

Development of an image analysis screen for estrogen receptor alpha (ERα) ligands through measurement of nuclear translocation dynamics.

Dull A, Goncharova E, Hager G, McMahon JB.

J Steroid Biochem Mol Biol. 2010 Nov;122(5):341-51. doi: 10.1016/j.jsbmb.2010.08.009. Epub 2010 Sep 17.

18.

Psoralidin, a coumestan analogue, as a novel potent estrogen receptor signaling molecule isolated from Psoralea corylifolia.

Liu X, Nam JW, Song YS, Viswanath AN, Pae AN, Kil YS, Kim HD, Park JH, Seo EK, Chang M.

Bioorg Med Chem Lett. 2014 Mar 1;24(5):1403-6. doi: 10.1016/j.bmcl.2014.01.029. Epub 2014 Jan 20.

PMID:
24507928
19.

Ginsenoside Rg1 exerts estrogen-like activities via ligand-independent activation of ERalpha pathway.

Lau WS, Chan RY, Guo DA, Wong MS.

J Steroid Biochem Mol Biol. 2008 Jan;108(1-2):64-71. Epub 2007 Sep 8.

PMID:
17936617
20.

A Data Analysis Pipeline Accounting for Artifacts in Tox21 Quantitative High-Throughput Screening Assays.

Hsieh JH, Sedykh A, Huang R, Xia M, Tice RR.

J Biomol Screen. 2015 Aug;20(7):887-97. doi: 10.1177/1087057115581317. Epub 2015 Apr 22.

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