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Items: 1 to 20 of 134

1.

Generic automated method for liquid chromatography-multiple reaction monitoring mass spectrometry based monoclonal antibody quantitation for preclinical pharmacokinetic studies.

Zhang Q, Spellman DS, Song Y, Choi B, Hatcher NG, Tomazela D, Beaumont M, Tabrizifard M, Prabhavalkar D, Seghezzi W, Harrelson J, Bateman KP.

Anal Chem. 2014 Sep 2;86(17):8776-84. doi: 10.1021/ac5019827.

PMID:
25010922
2.

General LC-MS/MS method approach to quantify therapeutic monoclonal antibodies using a common whole antibody internal standard with application to preclinical studies.

Li H, Ortiz R, Tran L, Hall M, Spahr C, Walker K, Laudemann J, Miller S, Salimi-Moosavi H, Lee JW.

Anal Chem. 2012 Feb 7;84(3):1267-73. doi: 10.1021/ac202792n.

PMID:
22243404
3.

A multiplexed hybrid LC-MS/MS pharmacokinetic assay to measure two co-administered monoclonal antibodies in a clinical study.

Xu K, Liu L, Maia M, Li J, Lowe J, Song A, Kaur S.

Bioanalysis. 2014;6(13):1781-94. doi: 10.4155/bio.14.142.

PMID:
25157485
4.

Fully validated LC-MS/MS assay for the simultaneous quantitation of coadministered therapeutic antibodies in cynomolgus monkey serum.

Jiang H, Zeng J, Titsch C, Voronin K, Akinsanya B, Luo L, Shen H, Desai DD, Allentoff A, Aubry AF, Desilva BS, Arnold ME.

Anal Chem. 2013 Oct 15;85(20):9859-67. doi: 10.1021/ac402420v.

PMID:
24024648
5.

Towards absolute quantification of therapeutic monoclonal antibody in serum by LC-MS/MS using isotope-labeled antibody standard and protein cleavage isotope dilution mass spectrometry.

Heudi O, Barteau S, Zimmer D, Schmidt J, Bill K, Lehmann N, Bauer C, Kretz O.

Anal Chem. 2008 Jun 1;80(11):4200-7. doi: 10.1021/ac800205s.

PMID:
18465883
6.

Critical role of bioanalytical strategies in investigation of clinical PK observations, a Phase I case study.

Peng K, Xu K, Liu L, Hendricks R, Delarosa R, Erickson R, Budha N, Leabman M, Song A, Kaur S, Fischer SK.

MAbs. 2014;6(6):1500-8. doi: 10.4161/mabs.36208.

7.

Evaluation of an immunoassay for human-specific quantitation of therapeutic antibodies in serum samples from non-human primates.

Stubenrauch K, Wessels U, Lenz H.

J Pharm Biomed Anal. 2009 May 1;49(4):1003-8. doi: 10.1016/j.jpba.2009.01.030.

PMID:
19250787
9.

A quantitative LC-MS/MS method for comparative analysis of capture-antibody affinity toward protein antigens.

Lowenthal MS, Gasca-Aragon H, Schiel JE, Dodder NG, Bunk DM.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Sep 15;879(26):2726-32. doi: 10.1016/j.jchromb.2011.07.037.

PMID:
21856254
10.

Comparison of bioanalytical methods for the quantitation of PEGylated human insulin.

de Dios K, Manibusan A, Marsden R, Pinkstaff J.

J Immunol Methods. 2013 Oct 31;396(1-2):1-7. doi: 10.1016/j.jim.2013.07.007.

PMID:
23933323
11.

A universal surrogate peptide to enable LC-MS/MS bioanalysis of a diversity of human monoclonal antibody and human Fc-fusion protein drug candidates in pre-clinical animal studies.

Furlong MT, Ouyang Z, Wu S, Tamura J, Olah T, Tymiak A, Jemal M.

Biomed Chromatogr. 2012 Aug;26(8):1024-32. doi: 10.1002/bmc.2759.

PMID:
22623136
12.

In vivo deamidation characterization of monoclonal antibody by LC/MS/MS.

Huang L, Lu J, Wroblewski VJ, Beals JM, Riggin RM.

Anal Chem. 2005 Mar 1;77(5):1432-9.

PMID:
15732928
13.

Quantitative determination of humanized monoclonal antibody rhuMAb2H7 in cynomolgus monkey serum using a Generic Immunoglobulin Pharmacokinetic (GRIP) assay.

Yang J, Ng C, Lowman H, Chestnut R, Schofield C, Sandlund B, Ernst J, Bennett G, Quarmby V.

J Immunol Methods. 2008 Jun 1;335(1-2):8-20. doi: 10.1016/j.jim.2008.01.016.

PMID:
18402977
14.

Bioanalytical platform comparison using a generic human IgG PK assay format.

Leary BA, Lawrence-Henderson R, Mallozzi C, Fernandez Ocaña M, Duriga N, O'Hara DM, Kavosi M, Qu Q, Joyce AP.

J Immunol Methods. 2013 Nov 29;397(1-2):28-36. doi: 10.1016/j.jim.2013.08.009.

PMID:
23994108
15.

Absolute and multiplex quantification of antibodies in serum using PSAQ™ standards and LC-MS/MS.

Lebert D, Picard G, Beau-Larvor C, Troncy L, Lacheny C, Maynadier B, Low W, Mouz N, Brun V, Klinguer-Hamour C, Jaquinod M, Beck A.

Bioanalysis. 2015;7(10):1237-51. doi: 10.4155/bio.15.56.

PMID:
25898209
16.

An exploratory universal LC-MS/MS assay for bioanalysis of hinge region-stabilized human IgG4 mAbs in clinical studies.

Furlong MT, Titsch C, Xu W, Jiang H, Jemal M, Zeng J.

Bioanalysis. 2014;6(13):1747-58. doi: 10.4155/bio.14.64.

PMID:
24661028
17.

Use of generic LC-MS/MS assays to characterize atypical PK profile of a biotherapeutic monoclonal antibody.

Law WS, Genin JC, Miess C, Treton G, Warren AP, Lloyd P, Dudal S, Krantz C.

Bioanalysis. 2014;6(23):3225-35. doi: 10.4155/bio.14.167.

PMID:
25529889
18.
20.

Clinical pharmacokinetic assessment of an anti-MAdCAM monoclonal antibody therapeutic by LC-MS/MS.

Fernández Ocaña M, James IT, Kabir M, Grace C, Yuan G, Martin SW, Neubert H.

Anal Chem. 2012 Jul 17;84(14):5959-67. doi: 10.1021/ac300600f.

PMID:
22816779

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