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Items: 1 to 20 of 112

1.

FUS is sequestered in nuclear aggregates in ALS patient fibroblasts.

Schwartz JC, Podell ER, Han SS, Berry JD, Eggan KC, Cech TR.

Mol Biol Cell. 2014 Sep 1;25(17):2571-8. doi: 10.1091/mbc.E14-05-1007. Epub 2014 Jul 9.

2.

Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis.

Lim SM, Choi WJ, Oh KW, Xue Y, Choi JY, Kim SH, Nahm M, Kim YE, Lee J, Noh MY, Lee S, Hwang S, Ki CS, Fu XD, Kim SH.

Mol Neurodegener. 2016 Jan 22;11:8. doi: 10.1186/s13024-016-0075-6.

3.

Mutations in the 3' untranslated region of FUS causing FUS overexpression are associated with amyotrophic lateral sclerosis.

Sabatelli M, Moncada A, Conte A, Lattante S, Marangi G, Luigetti M, Lucchini M, Mirabella M, Romano A, Del Grande A, Bisogni G, Doronzio PN, Rossini PM, Zollino M.

Hum Mol Genet. 2013 Dec 1;22(23):4748-55. doi: 10.1093/hmg/ddt328. Epub 2013 Jul 11.

PMID:
23847048
4.

FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2.

Schwartz JC, Ebmeier CC, Podell ER, Heimiller J, Taatjes DJ, Cech TR.

Genes Dev. 2012 Dec 15;26(24):2690-5. doi: 10.1101/gad.204602.112.

5.

Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations.

Tradewell ML, Yu Z, Tibshirani M, Boulanger MC, Durham HD, Richard S.

Hum Mol Genet. 2012 Jan 1;21(1):136-49. doi: 10.1093/hmg/ddr448. Epub 2011 Sep 28.

PMID:
21965298
6.

Aggregation of ALS-linked FUS mutant sequesters RNA binding proteins and impairs RNA granules formation.

Takanashi K, Yamaguchi A.

Biochem Biophys Res Commun. 2014 Sep 26;452(3):600-7. doi: 10.1016/j.bbrc.2014.08.115. Epub 2014 Aug 28.

PMID:
25173930
7.

RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations.

Daigle JG, Lanson NA Jr, Smith RB, Casci I, Maltare A, Monaghan J, Nichols CD, Kryndushkin D, Shewmaker F, Pandey UB.

Hum Mol Genet. 2013 Mar 15;22(6):1193-205. doi: 10.1093/hmg/dds526. Epub 2012 Dec 20.

8.

ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules.

Vance C, Scotter EL, Nishimura AL, Troakes C, Mitchell JC, Kathe C, Urwin H, Manser C, Miller CC, Hortobágyi T, Dragunow M, Rogelj B, Shaw CE.

Hum Mol Genet. 2013 Jul 1;22(13):2676-88. doi: 10.1093/hmg/ddt117. Epub 2013 Mar 7.

9.

Nuclear localization of SMN and FUS is not altered in fibroblasts from patients with sporadic ALS.

Kariya S, Sampson JB, Northrop LE, Luccarelli CM, Naini AB, Re DB, Hirano M, Mitsumoto H.

Amyotroph Lateral Scler Frontotemporal Degener. 2014 Dec;15(7-8):581-7. doi: 10.3109/21678421.2014.907319. Epub 2014 May 9.

10.
11.

Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis.

Nomura T, Watanabe S, Kaneko K, Yamanaka K, Nukina N, Furukawa Y.

J Biol Chem. 2014 Jan 10;289(2):1192-202. doi: 10.1074/jbc.M113.516492. Epub 2013 Nov 26.

12.

FUS-SMN protein interactions link the motor neuron diseases ALS and SMA.

Yamazaki T, Chen S, Yu Y, Yan B, Haertlein TC, Carrasco MA, Tapia JC, Zhai B, Das R, Lalancette-Hebert M, Sharma A, Chandran S, Sullivan G, Nishimura AL, Shaw CE, Gygi SP, Shneider NA, Maniatis T, Reed R.

Cell Rep. 2012 Oct 25;2(4):799-806. doi: 10.1016/j.celrep.2012.08.025. Epub 2012 Sep 27.

13.

ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.

Sun S, Ling SC, Qiu J, Albuquerque CP, Zhou Y, Tokunaga S, Li H, Qiu H, Bui A, Yeo GW, Huang EJ, Eggan K, Zhou H, Fu XD, Lagier-Tourenne C, Cleveland DW.

Nat Commun. 2015 Jan 27;6:6171. doi: 10.1038/ncomms7171.

14.

Treatment with a Global Methyltransferase Inhibitor Induces the Intranuclear Aggregation of ALS-Linked FUS Mutant In Vitro.

Fujii S, Takanashi K, Kitajo K, Yamaguchi A.

Neurochem Res. 2016 Apr;41(4):826-35. doi: 10.1007/s11064-015-1758-z. Epub 2015 Nov 24.

PMID:
26603295
15.

Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1.

Tibshirani M, Tradewell ML, Mattina KR, Minotti S, Yang W, Zhou H, Strong MJ, Hayward LJ, Durham HD.

Hum Mol Genet. 2015 Feb 1;24(3):773-86. doi: 10.1093/hmg/ddu494. Epub 2014 Sep 30.

16.

Self-assembled FUS binds active chromatin and regulates gene transcription.

Yang L, Gal J, Chen J, Zhu H.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17809-14. doi: 10.1073/pnas.1414004111. Epub 2014 Dec 1.

17.

Pur-alpha functionally interacts with FUS carrying ALS-associated mutations.

Di Salvio M, Piccinni V, Gerbino V, Mantoni F, Camerini S, Lenzi J, Rosa A, Chellini L, Loreni F, Carrì MT, Bozzoni I, Cozzolino M, Cestra G.

Cell Death Dis. 2015 Oct 22;6:e1943. doi: 10.1038/cddis.2015.295.

18.

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

Ling SC, Albuquerque CP, Han JS, Lagier-Tourenne C, Tokunaga S, Zhou H, Cleveland DW.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13318-23. doi: 10.1073/pnas.1008227107. Epub 2010 Jul 12.

19.

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.

Patel A, Lee HO, Jawerth L, Maharana S, Jahnel M, Hein MY, Stoynov S, Mahamid J, Saha S, Franzmann TM, Pozniakovski A, Poser I, Maghelli N, Royer LA, Weigert M, Myers EW, Grill S, Drechsel D, Hyman AA, Alberti S.

Cell. 2015 Aug 27;162(5):1066-77. doi: 10.1016/j.cell.2015.07.047.

20.

ALS mutations in TLS/FUS disrupt target gene expression.

Coady TH, Manley JL.

Genes Dev. 2015 Aug 15;29(16):1696-706. doi: 10.1101/gad.267286.115. Epub 2015 Aug 6.

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