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Items: 1 to 20 of 83


The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains.

Lin TF, Lin IW, Chen SC, Wu HH, Yang CS, Fang HY, Chiu MM, Jeng CJ.

J Biol Chem. 2014 Aug 15;289(33):22815-34. doi: 10.1074/jbc.M114.574814.


The Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels.

Lin TF, Jow GM, Fang HY, Fu SJ, Wu HH, Chiu MM, Jeng CJ.

PLoS One. 2014 Oct 21;9(10):e110423. doi: 10.1371/journal.pone.0110423.


Distal end of carboxyl terminus is not essential for the assembly of rat Eag1 potassium channels.

Chen IH, Hu JH, Jow GM, Chuang CC, Lee TT, Liu DC, Jeng CJ.

J Biol Chem. 2011 Aug 5;286(31):27183-96. doi: 10.1074/jbc.M111.233825.


External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor.

Kazmierczak M, Zhang X, Chen B, Mulkey DK, Shi Y, Wagner PG, Pivaroff-Ward K, Sassic JK, Bayliss DA, Jegla T.

J Gen Physiol. 2013 Jun;141(6):721-35. doi: 10.1085/jgp.201210938.


The structural mechanism of KCNH-channel regulation by the eag domain.

Haitin Y, Carlson AE, Zagotta WN.

Nature. 2013 Sep 19;501(7467):444-8. doi: 10.1038/nature12487.


Structure of the carboxy-terminal region of a KCNH channel.

Brelidze TI, Carlson AE, Sankaran B, Zagotta WN.

Nature. 2012 Jan 9;481(7382):530-3. doi: 10.1038/nature10735.


Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate.

Li X, Anishkin A, Liu H, van Rossum DB, Chintapalli SV, Sassic JK, Gallegos D, Pivaroff-Ward K, Jegla T.

J Gen Physiol. 2015 Nov;146(5):357-74. doi: 10.1085/jgp.201511491.


Effect of S5P alpha-helix charge mutants on inactivation of hERG K+ channels.

Clarke CE, Hill AP, Zhao J, Kondo M, Subbiah RN, Campbell TJ, Vandenberg JI.

J Physiol. 2006 Jun 1;573(Pt 2):291-304.


ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels.

Garg V, Stary-Weinzinger A, Sanguinetti MC.

Mol Pharmacol. 2013 Apr;83(4):805-13. doi: 10.1124/mol.112.084384.


Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain.

Schlichter LC, Jiang J, Wang J, Newell EW, Tsui FW, Lam D.

PLoS One. 2014 Feb 28;9(2):e90024. doi: 10.1371/journal.pone.0090024.


Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels.

Gianulis EC, Liu Q, Trudeau MC.

J Gen Physiol. 2013 Oct;142(4):351-66. doi: 10.1085/jgp.201310995.


C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels.

Ng CA, Ke Y, Perry MD, Tan PS, Hill AP, Vandenberg JI.

PLoS One. 2013 Oct 25;8(10):e77032. doi: 10.1371/journal.pone.0077032.


The punctate localization of rat Eag1 K+ channels is conferred by the proximal post-CNBHD region.

Chuang CC, Jow GM, Lin HM, Weng YH, Hu JH, Peng YJ, Chiu YC, Chiu MM, Jeng CJ.

BMC Neurosci. 2014 Feb 4;15:23. doi: 10.1186/1471-2202-15-23.


Functional analysis of a mouse brain Elk-type K+ channel.

Trudeau MC, Titus SA, Branchaw JL, Ganetzky B, Robertson GA.

J Neurosci. 1999 Apr 15;19(8):2906-18.


Molecular determinants of interactions between the N-terminal domain and the transmembrane core that modulate hERG K+ channel gating.

Fernández-Trillo J, Barros F, Machín A, Carretero L, Domínguez P, de la Peña P.

PLoS One. 2011;6(9):e24674. doi: 10.1371/journal.pone.0024674.


The subfamily-specific interaction between Kv2.1 and Kv6.4 subunits is determined by interactions between the N- and C-termini.

Bocksteins E, Mayeur E, Van Tilborg A, Regnier G, Timmermans JP, Snyders DJ.

PLoS One. 2014 Jun 5;9(6):e98960. doi: 10.1371/journal.pone.0098960.


Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule.

Garg V, Sachse FB, Sanguinetti MC.

J Gen Physiol. 2012 Sep;140(3):307-24. doi: 10.1085/jgp.201210826.

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