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Items: 1 to 20 of 129

1.

Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly.

Vajjhala PR, Kaiser S, Smith SJ, Ong QR, Soh SL, Stacey KJ, Hill JM.

J Biol Chem. 2014 Aug 22;289(34):23504-19. doi: 10.1074/jbc.M114.553305. Epub 2014 Jul 8.

2.

Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein.

Vajjhala PR, Mirams RE, Hill JM.

J Biol Chem. 2012 Dec 7;287(50):41732-43. doi: 10.1074/jbc.M112.381228. Epub 2012 Oct 12.

3.

The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments.

Vajjhala PR, Lu A, Brown DL, Pang SW, Sagulenko V, Sester DP, Cridland SO, Hill JM, Schroder K, Stow JL, Wu H, Stacey KJ.

J Biol Chem. 2015 Dec 4;290(49):29217-30. doi: 10.1074/jbc.M115.687731. Epub 2015 Oct 14.

4.

Structure of the absent in melanoma 2 (AIM2) pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly.

Jin T, Perry A, Smith P, Jiang J, Xiao TS.

J Biol Chem. 2013 May 10;288(19):13225-35. doi: 10.1074/jbc.M113.468033. Epub 2013 Mar 25.

5.

Inhibiting the inflammasome: one domain at a time.

Dorfleutner A, Chu L, Stehlik C.

Immunol Rev. 2015 May;265(1):205-16. doi: 10.1111/imr.12290. Review.

6.

ASC Pyrin Domain Self-associates and Binds NLRP3 Protein Using Equivalent Binding Interfaces.

Oroz J, Barrera-Vilarmau S, Alfonso C, Rivas G, de Alba E.

J Biol Chem. 2016 Sep 9;291(37):19487-501. doi: 10.1074/jbc.M116.741082. Epub 2016 Jul 18.

7.

Crystal structure of NALP3 protein pyrin domain (PYD) and its implications in inflammasome assembly.

Bae JY, Park HH.

J Biol Chem. 2011 Nov 11;286(45):39528-36. doi: 10.1074/jbc.M111.278812. Epub 2011 Aug 31.

8.

Purification and analysis of the interactions of caspase-1 and ASC for assembly of the inflammasome.

Narayanan KB, Park HH.

Appl Biochem Biotechnol. 2015 Mar;175(6):2883-94. doi: 10.1007/s12010-014-1471-4. Epub 2015 Jan 8.

PMID:
25567507
9.

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain.

Stutz A, Kolbe CC, Stahl R, Horvath GL, Franklin BS, van Ray O, Brinkschulte R, Geyer M, Meissner F, Latz E.

J Exp Med. 2017 Jun 5;214(6):1725-1736. doi: 10.1084/jem.20160933. Epub 2017 May 2.

PMID:
28465465
10.

Self-oligomerization of ASC PYD domain prevents the assembly of inflammasome in vitro.

Narayanan KB, Jang TH, Park HH.

Appl Biochem Biotechnol. 2014 Apr;172(8):3902-12. doi: 10.1007/s12010-014-0819-0. Epub 2014 Mar 2.

PMID:
24585381
11.

Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.

Dorfleutner A, Bryan NB, Talbott SJ, Funya KN, Rellick SL, Reed JC, Shi X, Rojanasakul Y, Flynn DC, Stehlik C.

Infect Immun. 2007 Mar;75(3):1484-92. Epub 2006 Dec 18.

12.

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome.

Xu H, Yang J, Gao W, Li L, Li P, Zhang L, Gong YN, Peng X, Xi JJ, Chen S, Wang F, Shao F.

Nature. 2014 Sep 11;513(7517):237-41. doi: 10.1038/nature13449. Epub 2014 Jun 11.

PMID:
24919149
13.

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.

Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H, Egelman EH.

Cell. 2014 Mar 13;156(6):1193-1206. doi: 10.1016/j.cell.2014.02.008.

14.

Mapping of POP1-binding site on pyrin domain of ASC.

Srimathi T, Robbins SL, Dubas RL, Chang H, Cheng H, Roder H, Park YC.

J Biol Chem. 2008 May 30;283(22):15390-8. doi: 10.1074/jbc.M801589200. Epub 2008 Mar 24.

15.

Structural mechanisms of inflammasome assembly.

Lu A, Wu H.

FEBS J. 2015 Feb;282(3):435-44. doi: 10.1111/febs.13133. Epub 2014 Nov 21. Review.

16.

The CARD plays a critical role in ASC foci formation and inflammasome signalling.

Proell M, Gerlic M, Mace PD, Reed JC, Riedl SJ.

Biochem J. 2013 Feb 1;449(3):613-21. doi: 10.1042/BJ20121198.

17.

An updated view on the structure and function of PYRIN domains.

Chu LH, Gangopadhyay A, Dorfleutner A, Stehlik C.

Apoptosis. 2015 Feb;20(2):157-73. doi: 10.1007/s10495-014-1065-1.

18.

Ribotoxic stress through p38 mitogen-activated protein kinase activates in vitro the human pyrin inflammasome.

Yu JW, Farias A, Hwang I, Fernandes-Alnemri T, Alnemri ES.

J Biol Chem. 2013 Apr 19;288(16):11378-83. doi: 10.1074/jbc.M112.448795. Epub 2013 Mar 11.

19.

Crystal structure of the F27G AIM2 PYD mutant and similarities of its self-association to DED/DED interactions.

Lu A, Kabaleeswaran V, Fu T, Magupalli VG, Wu H.

J Mol Biol. 2014 Apr 3;426(7):1420-7. doi: 10.1016/j.jmb.2013.12.029. Epub 2014 Jan 7.

20.

Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC.

Taniguchi S, Sagara J.

Semin Immunopathol. 2007 Sep;29(3):231-8. Epub 2007 Sep 6. Review.

PMID:
17805543

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