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Items: 1 to 20 of 169


Exploring the RING-catalyzed ubiquitin transfer mechanism by MD and QM/MM calculations.

Zhen Y, Qin G, Luo C, Jiang H, Yu K, Chen G.

PLoS One. 2014 Jul 8;9(7):e101663. doi: 10.1371/journal.pone.0101663. eCollection 2014.


Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis.

Plechanovová A, Jaffray EG, Tatham MH, Naismith JH, Hay RT.

Nature. 2012 Sep 6;489(7414):115-20. doi: 10.1038/nature11376.


Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases.

Pruneda JN, Littlefield PJ, Soss SE, Nordquist KA, Chazin WJ, Brzovic PS, Klevit RE.

Mol Cell. 2012 Sep 28;47(6):933-42. doi: 10.1016/j.molcel.2012.07.001. Epub 2012 Aug 9.


Activation of a primed RING E3-E2-ubiquitin complex by non-covalent ubiquitin.

Buetow L, Gabrielsen M, Anthony NG, Dou H, Patel A, Aitkenhead H, Sibbet GJ, Smith BO, Huang DT.

Mol Cell. 2015 Apr 16;58(2):297-310. doi: 10.1016/j.molcel.2015.02.017. Epub 2015 Mar 19.


Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase.

Nakatani Y, Kleffmann T, Linke K, Condon SM, Hinds MG, Day CL.

Biochem J. 2013 Mar 15;450(3):629-38. doi: 10.1042/BJ20121702.


Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation.

Lechtenberg BC, Rajput A, Sanishvili R, Dobaczewska MK, Ware CF, Mace PD, Riedl SJ.

Nature. 2016 Jan 28;529(7587):546-50. doi: 10.1038/nature16511. Epub 2016 Jan 20.


Mechanism of ubiquitylation by dimeric RING ligase RNF4.

Plechanovová A, Jaffray EG, McMahon SA, Johnson KA, Navrátilová I, Naismith JH, Hay RT.

Nat Struct Mol Biol. 2011 Aug 21;18(9):1052-9. doi: 10.1038/nsmb.2108.


E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP.

Soss SE, Yue Y, Dhe-Paganon S, Chazin WJ.

J Biol Chem. 2011 Jun 17;286(24):21277-86. doi: 10.1074/jbc.M111.224006. Epub 2011 Apr 25.


RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex.

Brown NG, VanderLinden R, Watson ER, Qiao R, Grace CR, Yamaguchi M, Weissmann F, Frye JJ, Dube P, Ei Cho S, Actis ML, Rodrigues P, Fujii N, Peters JM, Stark H, Schulman BA.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5272-9. doi: 10.1073/pnas.1504161112. Epub 2015 Mar 30.


BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.

Dou H, Buetow L, Sibbet GJ, Cameron K, Huang DT.

Nat Struct Mol Biol. 2012 Sep;19(9):876-83. doi: 10.1038/nsmb.2379. Epub 2012 Aug 14.


Capturing a substrate in an activated RING E3/E2-SUMO complex.

Streich FC Jr, Lima CD.

Nature. 2016 Aug 18;536(7616):304-8. Epub 2016 Aug 10.


Structural insights into the conformation and oligomerization of E2~ubiquitin conjugates.

Page RC, Pruneda JN, Amick J, Klevit RE, Misra S.

Biochemistry. 2012 May 22;51(20):4175-87. doi: 10.1021/bi300058m. Epub 2012 May 14.


UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.

Wenzel DM, Lissounov A, Brzovic PS, Klevit RE.

Nature. 2011 Jun 2;474(7349):105-8. doi: 10.1038/nature09966. Epub 2011 May 1.


Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity.

Wright JD, Mace PD, Day CL.

Nat Struct Mol Biol. 2016 Jan;23(1):45-52. doi: 10.1038/nsmb.3142. Epub 2015 Dec 14.


Molecular basis for lysine specificity in the yeast ubiquitin-conjugating enzyme Cdc34.

Sadowski M, Suryadinata R, Lai X, Heierhorst J, Sarcevic B.

Mol Cell Biol. 2010 May;30(10):2316-29. doi: 10.1128/MCB.01094-09. Epub 2010 Mar 1.


Engineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transfer.

Qian SB, Waldron L, Choudhary N, Klevit RE, Chazin WJ, Patterson C.

J Biol Chem. 2009 Sep 25;284(39):26797-802. doi: 10.1074/jbc.M109.032334. Epub 2009 Jul 31.


Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3.

Dou H, Buetow L, Sibbet GJ, Cameron K, Huang DT.

Nat Struct Mol Biol. 2013 Aug;20(8):982-986. doi: 10.1038/nsmb.2621. Epub 2013 Jul 14.


Formation of nondegradable forked ubiquitin conjugates by ring-finger ligases and its prevention by S5a.

Kim HT, Goldberg AL.

Methods Mol Biol. 2012;832:639-52. doi: 10.1007/978-1-61779-474-2_45.


A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

Sheng Y, Hong JH, Doherty R, Srikumar T, Shloush J, Avvakumov GV, Walker JR, Xue S, Neculai D, Wan JW, Kim SK, Arrowsmith CH, Raught B, Dhe-Paganon S.

Mol Cell Proteomics. 2012 Aug;11(8):329-41. doi: 10.1074/mcp.O111.013706. Epub 2012 Apr 10.


Structure and Function of the RING Domains of RNF20 and RNF40, Dimeric E3 Ligases that Monoubiquitylate Histone H2B.

Foglizzo M, Middleton AJ, Day CL.

J Mol Biol. 2016 Oct 9;428(20):4073-4086. doi: 10.1016/j.jmb.2016.07.025. Epub 2016 Aug 25.


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