Similar articles for PMID: 25001311

Year	Number of Results
2001	1
2002	1
2004	4
2005	4
2006	2
2007	5
2008	2
2009	1
2010	6
2011	8
2012	7
2013	15
2014	11
2015	9
2016	5
2017	1
2018	5
2019	7
2020	5
2021	7
2022	4
2023	2
2024	0

1

Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis.

Trippier PC, Zhao KT, Fox SG, Schiefer IT, Benmohamed R, Moran J, Kirsch DR, Morimoto RI, Silverman RB. Trippier PC, et al. ACS Chem Neurosci. 2014 Sep 17;5(9):823-9. doi: 10.1021/cn500147v. Epub 2014 Jul 18. ACS Chem Neurosci. 2014. PMID: 25001311 Free PMC article.

2

Substituted pyrazolones require N2 hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1.

Trippier PC, Benmohamed R, Kirsch DR, Silverman RB. Trippier PC, et al. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6647-50. doi: 10.1016/j.bmcl.2012.08.114. Epub 2012 Sep 7. Bioorg Med Chem Lett. 2012. PMID: 23021992 Free PMC article.

3

Tertiary Amine Pyrazolones and Their Salts as Inhibitors of Mutant Superoxide Dismutase 1-Dependent Protein Aggregation for the Treatment of Amyotrophic Lateral Sclerosis.

Zhang Y, Zhao KT, Fox SG, Kim J, Kirsch DR, Ferrante RJ, Morimoto RI, Silverman RB. Zhang Y, et al. J Med Chem. 2015 Aug 13;58(15):5942-9. doi: 10.1021/acs.jmedchem.5b00561. Epub 2015 Jul 31. J Med Chem. 2015. PMID: 26186011 Free PMC article.

4

Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis.

Chen T, Benmohamed R, Arvanites AC, Ralay Ranaivo H, Morimoto RI, Ferrante RJ, Watterson DM, Kirsch DR, Silverman RB. Chen T, et al. Bioorg Med Chem. 2011 Jan 1;19(1):613-22. doi: 10.1016/j.bmc.2010.10.052. Epub 2010 Oct 30. Bioorg Med Chem. 2011. PMID: 21095130 Free PMC article.

5

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

Crippa V, Sau D, Rusmini P, Boncoraglio A, Onesto E, Bolzoni E, Galbiati M, Fontana E, Marino M, Carra S, Bendotti C, De Biasi S, Poletti A. Crippa V, et al. Hum Mol Genet. 2010 Sep 1;19(17):3440-56. doi: 10.1093/hmg/ddq257. Epub 2010 Jun 22. Hum Mol Genet. 2010. PMID: 20570967 Free article.

6

ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis.

Chen T, Benmohamed R, Kim J, Smith K, Amante D, Morimoto RI, Kirsch DR, Ferrante RJ, Silverman RB. Chen T, et al. J Med Chem. 2012 Jan 12;55(1):515-27. doi: 10.1021/jm2014277. Epub 2011 Dec 22. J Med Chem. 2012. PMID: 22191331 Free PMC article.

7

CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70.

Urushitani M, Kurisu J, Tateno M, Hatakeyama S, Nakayama K, Kato S, Takahashi R. Urushitani M, et al. J Neurochem. 2004 Jul;90(1):231-44. doi: 10.1111/j.1471-4159.2004.02486.x. J Neurochem. 2004. PMID: 15198682 Free article.

8

Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues.

Watanabe M, Dykes-Hoberg M, Culotta VC, Price DL, Wong PC, Rothstein JD. Watanabe M, et al. Neurobiol Dis. 2001 Dec;8(6):933-41. doi: 10.1006/nbdi.2001.0443. Neurobiol Dis. 2001. PMID: 11741389

9

RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue.

Vallarola A, Sironi F, Tortarolo M, Gatto N, De Gioia R, Pasetto L, De Paola M, Mariani A, Ghosh S, Watson R, Kalmes A, Bonetto V, Bendotti C. Vallarola A, et al. J Neuroinflammation. 2018 Mar 1;15(1):65. doi: 10.1186/s12974-018-1101-0. J Neuroinflammation. 2018. PMID: 29495962 Free PMC article.

10

Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis.

Poon HF, Hensley K, Thongboonkerd V, Merchant ML, Lynn BC, Pierce WM, Klein JB, Calabrese V, Butterfield DA. Poon HF, et al. Free Radic Biol Med. 2005 Aug 15;39(4):453-62. doi: 10.1016/j.freeradbiomed.2005.03.030. Epub 2005 Apr 14. Free Radic Biol Med. 2005. PMID: 16043017

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