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Items: 1 to 20 of 338


Label-free proteomic analysis of environmental acidification-influenced Streptococcus pyogenes secretome reveals a novel acid-induced protein histidine triad protein A (HtpA) involved in necrotizing fasciitis.

Wen YT, Wang JS, Tsai SH, Chuan CN, Wu JJ, Liao PC.

J Proteomics. 2014 Sep 23;109:90-103. doi: 10.1016/j.jprot.2014.06.026. Epub 2014 Jul 3.


Differential secretomics of Streptococcus pyogenes reveals a novel peroxide regulator (PerR)-regulated extracellular virulence factor mitogen factor 3 (MF3).

Wen YT, Tsou CC, Kuo HT, Wang JS, Wu JJ, Liao PC.

Mol Cell Proteomics. 2011 Sep;10(9):M110.007013. doi: 10.1074/mcp.M110.007013. Epub 2011 Jun 2.


Complement-mediated opsonization of invasive group A Streptococcus pyogenes strain AP53 is regulated by the bacterial two-component cluster of virulence responder/sensor (CovRS) system.

Agrahari G, Liang Z, Mayfield JA, Balsara RD, Ploplis VA, Castellino FJ.

J Biol Chem. 2013 Sep 20;288(38):27494-504. doi: 10.1074/jbc.M113.494864. Epub 2013 Aug 8.


Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes.

Wisniewska M, Happonen L, Kahn F, Varjosalo M, Malmström L, Rosenberger G, Karlsson C, Cazzamali G, Pozdnyakova I, Frick IM, Björck L, Streicher W, Malmström J, Wikström M.

J Biol Chem. 2014 Jun 27;289(26):18175-88. doi: 10.1074/jbc.M114.565978. Epub 2014 May 13.


A comprehensive analysis of the Streptococcus pyogenes and human plasma protein interaction network.

Sjöholm K, Karlsson C, Linder A, Malmström J.

Mol Biosyst. 2014 Jul;10(7):1698-708. doi: 10.1039/c3mb70555b. Epub 2014 Feb 14.


Trading Capsule for Increased Cytotoxin Production: Contribution to Virulence of a Newly Emerged Clade of emm89 Streptococcus pyogenes.

Zhu L, Olsen RJ, Nasser W, de la Riva Morales I, Musser JM.

MBio. 2015 Oct 6;6(5):e01378-15. doi: 10.1128/mBio.01378-15.


RivR is a negative regulator of virulence factor expression in group A Streptococcus.

Treviño J, Liu Z, Cao TN, Ramirez-Peña E, Sumby P.

Infect Immun. 2013 Jan;81(1):364-72. doi: 10.1128/IAI.00703-12. Epub 2012 Nov 12.


Necrotizing soft tissue infections caused by Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis of groups C and G in western Norway.

Bruun T, Kittang BR, de Hoog BJ, Aardal S, Flaatten HK, Langeland N, Mylvaganam H, Vindenes HA, Skrede S.

Clin Microbiol Infect. 2013 Dec;19(12):E545-50. doi: 10.1111/1469-0691.12276. Epub 2013 Jun 25.


Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract.

Kurupati P, Turner CE, Tziona I, Lawrenson RA, Alam FM, Nohadani M, Stamp GW, Zinkernagel AS, Nizet V, Edwards RJ, Sriskandan S.

Mol Microbiol. 2010 Jun;76(6):1387-97. doi: 10.1111/j.1365-2958.2010.07065.x. Epub 2010 Feb 10.


First Streptococcus pyogenes signature-tagged mutagenesis screen identifies novel virulence determinants.

Kizy AE, Neely MN.

Infect Immun. 2009 May;77(5):1854-65. doi: 10.1128/IAI.01306-08. Epub 2009 Feb 17.


A natural inactivating mutation in the CovS component of the CovRS regulatory operon in a pattern D Streptococcal pyogenes strain influences virulence-associated genes.

Liang Z, Zhang Y, Agrahari G, Chandrahas V, Glinton K, Donahue DL, Balsara RD, Ploplis VA, Castellino FJ.

J Biol Chem. 2013 Mar 1;288(9):6561-73. doi: 10.1074/jbc.M112.442657. Epub 2013 Jan 13.


Molecular pathogenesis of necrotizing fasciitis.

Olsen RJ, Musser JM.

Annu Rev Pathol. 2010;5:1-31. doi: 10.1146/annurev-pathol-121808-102135. Review.


Streptococcus pyogenes Ser/Thr kinase-regulated cell wall hydrolase is a cell division plane-recognizing and chain-forming virulence factor.

Pancholi V, Boël G, Jin H.

J Biol Chem. 2010 Oct 1;285(40):30861-74. doi: 10.1074/jbc.M110.153825. Epub 2010 Jul 19.


Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity.

Bao YJ, Liang Z, Mayfield JA, Donahue DL, Carothers KE, Lee SW, Ploplis VA, Castellino FJ.

J Bacteriol. 2016 May 27;198(12):1712-24. doi: 10.1128/JB.01019-15. Print 2016 Jun 15.


Surface export of GAPDH/SDH, a glycolytic enzyme, is essential for Streptococcus pyogenes virulence.

Jin H, Agarwal S, Agarwal S, Pancholi V.

MBio. 2011 May 31;2(3):e00068-11. doi: 10.1128/mBio.00068-11. Print 2011.


A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus.

Shelburne SA 3rd, Keith D, Horstmann N, Sumby P, Davenport MT, Graviss EA, Brennan RG, Musser JM.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1698-703. doi: 10.1073/pnas.0711767105. Epub 2008 Jan 29. Erratum in: Proc Natl Acad Sci U S A. 2009 May 26;106(21):8790.


The majority of 9,729 group A streptococcus strains causing disease secrete SpeB cysteine protease: pathogenesis implications.

Olsen RJ, Raghuram A, Cantu C, Hartman MH, Jimenez FE, Lee S, Ngo A, Rice KA, Saddington D, Spillman H, Valson C, Flores AR, Beres SB, Long SW, Nasser W, Musser JM.

Infect Immun. 2015 Dec;83(12):4750-8. doi: 10.1128/IAI.00989-15. Epub 2015 Sep 28.


An amino-terminal signal peptide of Vfr protein negatively influences RopB-dependent SpeB expression and attenuates virulence in Streptococcus pyogenes.

Shelburne SA 3rd, Olsen RJ, Makthal N, Brown NG, Sahasrabhojane P, Watkins EM, Palzkill T, Musser JM, Kumaraswami M.

Mol Microbiol. 2011 Dec;82(6):1481-95. doi: 10.1111/j.1365-2958.2011.07902.x. Epub 2011 Nov 21.

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