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Items: 1 to 20 of 375

1.

Strategies to fine-map genetic associations with lipid levels by combining epigenomic annotations and liver-specific transcription profiles.

Lo KS, Vadlamudi S, Fogarty MP, Mohlke KL, Lettre G.

Genomics. 2014 Aug;104(2):105-12. doi: 10.1016/j.ygeno.2014.04.006. Epub 2014 Jul 2.

2.

On the identification of potential regulatory variants within genome wide association candidate SNP sets.

Chen CY, Chang IS, Hsiung CA, Wasserman WW.

BMC Med Genomics. 2014 Jun 11;7:34. doi: 10.1186/1755-8794-7-34.

3.

Genome-wide analyses of ChIP-Seq derived FOXA2 DNA occupancy in liver points to genetic networks underpinning multiple complex traits.

Johnson ME, Schug J, Wells AD, Kaestner KH, Grant SF.

J Clin Endocrinol Metab. 2014 Aug;99(8):E1580-5. doi: 10.1210/jc.2013-4503. Epub 2014 May 30.

4.

Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus.

Fogarty MP, Cannon ME, Vadlamudi S, Gaulton KJ, Mohlke KL.

PLoS Genet. 2014 Sep 11;10(9):e1004633. doi: 10.1371/journal.pgen.1004633. eCollection 2014 Sep.

5.

Identifying causal regulatory SNPs in ChIP-seq enhancers.

Huang D, Ovcharenko I.

Nucleic Acids Res. 2015 Jan;43(1):225-36. doi: 10.1093/nar/gku1318. Epub 2014 Dec 17.

6.

Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq.

Motallebipour M, Ameur A, Reddy Bysani MS, Patra K, Wallerman O, Mangion J, Barker MA, McKernan KJ, Komorowski J, Wadelius C.

Genome Biol. 2009;10(11):R129. doi: 10.1186/gb-2009-10-11-r129. Epub 2009 Nov 17.

7.

Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing.

Wallerman O, Motallebipour M, Enroth S, Patra K, Bysani MS, Komorowski J, Wadelius C.

Nucleic Acids Res. 2009 Dec;37(22):7498-508. doi: 10.1093/nar/gkp823.

8.

Most brain disease-associated and eQTL haplotypes are not located within transcription factor DNase-seq footprints in brain.

Handel AE, Gallone G, Zameel Cader M, Ponting CP.

Hum Mol Genet. 2017 Jan 1;26(1):79-89. doi: 10.1093/hmg/ddw369.

9.

Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells.

López Rodríguez M, Kaminska D, Lappalainen K, Pihlajamäki J, Kaikkonen MU, Laakso M.

Genome Med. 2017 Jul 6;9(1):63. doi: 10.1186/s13073-017-0453-x.

10.

Molecular Characterization of the Lipid Genome-Wide Association Study Signal on Chromosome 18q11.2 Implicates HNF4A-Mediated Regulation of the TMEM241 Gene.

Rodríguez A, Gonzalez L, Ko A, Alvarez M, Miao Z, Bhagat Y, Nikkola E, Cruz-Bautista I, Arellano-Campos O, Muñoz-Hernández LL, Ordóñez-Sánchez ML, Rodriguez-Guillen R, Mohlke KL, Laakso M, Tusie-Luna T, Aguilar-Salinas CA, Pajukanta P.

Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1350-5. doi: 10.1161/ATVBAHA.116.307182. Epub 2016 May 19.

11.

Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver.

Hoffman BG, Robertson G, Zavaglia B, Beach M, Cullum R, Lee S, Soukhatcheva G, Li L, Wederell ED, Thiessen N, Bilenky M, Cezard T, Tam A, Kamoh B, Birol I, Dai D, Zhao Y, Hirst M, Verchere CB, Helgason CD, Marra MA, Jones SJ, Hoodless PA.

Genome Res. 2010 Aug;20(8):1037-51. doi: 10.1101/gr.104356.109. Epub 2010 Jun 15.

12.

Global analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencing.

Wederell ED, Bilenky M, Cullum R, Thiessen N, Dagpinar M, Delaney A, Varhol R, Zhao Y, Zeng T, Bernier B, Ingham M, Hirst M, Robertson G, Marra MA, Jones S, Hoodless PA.

Nucleic Acids Res. 2008 Aug;36(14):4549-64. doi: 10.1093/nar/gkn382. Epub 2008 Jul 8.

13.

Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding.

Robertson AG, Bilenky M, Tam A, Zhao Y, Zeng T, Thiessen N, Cezard T, Fejes AP, Wederell ED, Cullum R, Euskirchen G, Krzywinski M, Birol I, Snyder M, Hoodless PA, Hirst M, Marra MA, Jones SJ.

Genome Res. 2008 Dec;18(12):1906-17. doi: 10.1101/gr.078519.108. Epub 2008 Sep 11.

14.

Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements.

Rye M, Sætrom P, Håndstad T, Drabløs F.

BMC Biol. 2011 Nov 24;9:80. doi: 10.1186/1741-7007-9-80.

15.

Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol.

Roman TS, Marvelle AF, Fogarty MP, Vadlamudi S, Gonzalez AJ, Buchkovich ML, Huyghe JR, Fuchsberger C, Jackson AU, Wu Y, Civelek M, Lusis AJ, Gaulton KJ, Sethupathy P, Kangas AJ, Soininen P, Ala-Korpela M, Kuusisto J, Collins FS, Laakso M, Boehnke M, Mohlke KL.

Am J Hum Genet. 2015 Dec 3;97(6):801-15. doi: 10.1016/j.ajhg.2015.10.016.

16.

Computational analyses of type 2 diabetes-associated loci identified by genome-wide association studies.

Cheng M, Liu X, Yang M, Han L, Xu A, Huang Q.

J Diabetes. 2017 Apr;9(4):362-377. doi: 10.1111/1753-0407.12421. Epub 2016 Jul 27.

PMID:
27121852
17.

Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23.1.

Biancolella M, Fortini BK, Tring S, Plummer SJ, Mendoza-Fandino GA, Hartiala J, Hitchler MJ, Yan C, Schumacher FR, Conti DV, Edlund CK, Noushmehr H, Coetzee SG, Bresalier RS, Ahnen DJ, Barry EL, Berman BP, Rice JC, Coetzee GA, Casey G.

Hum Mol Genet. 2014 Apr 15;23(8):2198-209. doi: 10.1093/hmg/ddt584. Epub 2013 Nov 20.

18.

Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3.

Frietze S, Wang R, Yao L, Tak YG, Ye Z, Gaddis M, Witt H, Farnham PJ, Jin VX.

Genome Biol. 2012 Sep 26;13(9):R52. doi: 10.1186/gb-2012-13-9-r52.

19.

Epigenetic and genetic alterations and their influence on gene regulation in chronic lymphocytic leukemia.

Huang D, Ovcharenko I.

BMC Genomics. 2017 Mar 16;18(1):236. doi: 10.1186/s12864-017-3617-6.

20.

Identification of breast cancer associated variants that modulate transcription factor binding.

Liu Y, Walavalkar NM, Dozmorov MG, Rich SS, Civelek M, Guertin MJ.

PLoS Genet. 2017 Sep 28;13(9):e1006761. doi: 10.1371/journal.pgen.1006761. eCollection 2017 Sep.

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