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Tetherin can restrict cell-free and cell-cell transmission of HIV from primary macrophages to T cells.

Giese S, Marsh M.

PLoS Pathog. 2014 Jul 3;10(7):e1004189. doi: 10.1371/journal.ppat.1004189.


Cell-cell spread of human immunodeficiency virus type 1 overcomes tetherin/BST-2-mediated restriction in T cells.

Jolly C, Booth NJ, Neil SJ.

J Virol. 2010 Dec;84(23):12185-99. doi: 10.1128/JVI.01447-10.


Tetherin/BST-2 is essential for the formation of the intracellular virus-containing compartment in HIV-infected macrophages.

Chu H, Wang JJ, Qi M, Yoon JJ, Chen X, Wen X, Hammonds J, Ding L, Spearman P.

Cell Host Microbe. 2012 Sep 13;12(3):360-72. doi: 10.1016/j.chom.2012.07.011.


TLR-4 engagement of dendritic cells confers a BST-2/tetherin-mediated restriction of HIV-1 infection to CD4+ T cells across the virological synapse.

Blanchet FP, Stalder R, Czubala M, Lehmann M, Rio L, Mangeat B, Piguet V.

Retrovirology. 2013 Jan 11;10:6. doi: 10.1186/1742-4690-10-6.


Tetherin restricts direct cell-to-cell infection of HIV-1.

Kuhl BD, Sloan RD, Donahue DA, Bar-Magen T, Liang C, Wainberg MA.

Retrovirology. 2010 Dec 24;7:115. doi: 10.1186/1742-4690-7-115.


Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue.

Schindler M, Rajan D, Banning C, Wimmer P, Koppensteiner H, Iwanski A, Specht A, Sauter D, Dobner T, Kirchhoff F.

Retrovirology. 2010 Jan 15;7:1. doi: 10.1186/1742-4690-7-1.


Tetherin restricts productive HIV-1 cell-to-cell transmission.

Casartelli N, Sourisseau M, Feldmann J, Guivel-Benhassine F, Mallet A, Marcelin AG, Guatelli J, Schwartz O.

PLoS Pathog. 2010 Jun 17;6(6):e1000955. doi: 10.1371/journal.ppat.1000955.


HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction.

Schmidt S, Fritz JV, Bitzegeio J, Fackler OT, Keppler OT.

MBio. 2011;2(3):e00036-11. doi: 10.1128/mBio.00036-11.


Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism.

Douglas JL, Viswanathan K, McCarroll MN, Gustin JK, Früh K, Moses AV.

J Virol. 2009 Aug;83(16):7931-47. doi: 10.1128/JVI.00242-09.


The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation.

Janvier K, Pelchen-Matthews A, Renaud JB, Caillet M, Marsh M, Berlioz-Torrent C.

PLoS Pathog. 2011 Feb 3;7(2):e1001265. doi: 10.1371/journal.ppat.1001265.


HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells.

Alvarez RA, Hamlin RE, Monroe A, Moldt B, Hotta MT, Rodriguez Caprio G, Fierer DS, Simon V, Chen BK.

J Virol. 2014 Jun;88(11):6031-46. doi: 10.1128/JVI.00449-14.


HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation.

Mangeat B, Gers-Huber G, Lehmann M, Zufferey M, Luban J, Piguet V.

PLoS Pathog. 2009 Sep;5(9):e1000574. doi: 10.1371/journal.ppat.1000574.


BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction.

Miyakawa K, Ryo A, Murakami T, Ohba K, Yamaoka S, Fukuda M, Guatelli J, Yamamoto N.

PLoS Pathog. 2009 Dec;5(12):e1000700. doi: 10.1371/journal.ppat.1000700.


Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment.

Dubé M, Roy BB, Guiot-Guillain P, Binette J, Mercier J, Chiasson A, Cohen EA.

PLoS Pathog. 2010 Apr 8;6(4):e1000856. doi: 10.1371/journal.ppat.1000856.


HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment.

Hauser H, Lopez LA, Yang SJ, Oldenburg JE, Exline CM, Guatelli JC, Cannon PM.

Retrovirology. 2010 Jun 7;7:51. doi: 10.1186/1742-4690-7-51. Erratum in: Retrovirology. 2011;8:85.


Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion.

Gupta RK, Hué S, Schaller T, Verschoor E, Pillay D, Towers GJ.

PLoS Pathog. 2009 May;5(5):e1000443. doi: 10.1371/journal.ppat.1000443.


Vpu-mediated tetherin antagonism of ongoing HIV-1 infection in CD4(+) T-cells is not directly related to the extent of tetherin cell surface downmodulation.

Kuhl BD, Sloan RD, Donahue DA, Liang C, Wainberg MA.

Virology. 2011 Sep 1;417(2):353-61. doi: 10.1016/j.virol.2011.06.012.

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