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Bioactives of Artemisia dracunculus L. enhance insulin sensitivity by modulation of ceramide metabolism in rat skeletal muscle cells.

Obanda DN, Ribnicky DM, Raskin I, Cefalu WT.

Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S59-66. doi: 10.1016/j.nut.2014.03.006. Epub 2014 Mar 19.


Bioactives of Artemisia dracunculus L. mitigate the role of ceramides in attenuating insulin signaling in rat skeletal muscle cells.

Obanda DN, Hernandez A, Ribnicky D, Yu Y, Zhang XH, Wang ZQ, Cefalu WT.

Diabetes. 2012 Mar;61(3):597-605. doi: 10.2337/db11-0396. Epub 2012 Feb 7.


Artemisia dracunculus L. extract ameliorates insulin sensitivity by attenuating inflammatory signalling in human skeletal muscle culture.

Vandanmagsar B, Haynie KR, Wicks SE, Bermudez EM, Mendoza TM, Ribnicky D, Cefalu WT, Mynatt RL.

Diabetes Obes Metab. 2014 Aug;16(8):728-38. doi: 10.1111/dom.12274. Epub 2014 Mar 10.


Bioactives from Artemisia dracunculus L. enhance insulin sensitivity via modulation of skeletal muscle protein phosphorylation.

Kheterpal I, Scherp P, Kelley L, Wang Z, Johnson W, Ribnicky D, Cefalu WT.

Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S43-51. doi: 10.1016/j.nut.2014.05.001. Epub 2014 May 13.


Bioactives of Artemisia dracunculus L enhance cellular insulin signaling in primary human skeletal muscle culture.

Wang ZQ, Ribnicky D, Zhang XH, Raskin I, Yu Y, Cefalu WT.

Metabolism. 2008 Jul;57(7 Suppl 1):S58-64. doi: 10.1016/j.metabol.2008.04.003.


Modulation of cellular insulin signaling and PTP1B effects by lipid metabolites in skeletal muscle cells.

Obanda DN, Cefalu WT.

J Nutr Biochem. 2013 Aug;24(8):1529-37. doi: 10.1016/j.jnutbio.2012.12.014. Epub 2013 Mar 6.


An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes.

Kirk-Ballard H, Wang ZQ, Acharya P, Zhang XH, Yu Y, Kilroy G, Ribnicky D, Cefalu WT, Floyd ZE.

PLoS One. 2013;8(2):e57112. doi: 10.1371/journal.pone.0057112. Epub 2013 Feb 20.


Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment.

Frangioudakis G, Diakanastasis B, Liao BQ, Saville JT, Hoffman NJ, Mitchell TW, Schmitz-Peiffer C.

Diabetologia. 2013 Dec;56(12):2697-701. doi: 10.1007/s00125-013-3035-5. Epub 2013 Aug 29.


An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-A(y) mice.

Wang ZQ, Ribnicky D, Zhang XH, Zuberi A, Raskin I, Yu Y, Cefalu WT.

J Nutr Biochem. 2011 Jan;22(1):71-8. doi: 10.1016/j.jnutbio.2009.11.015. Epub 2010 May 5.


Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight.

Mahfouz R, Khoury R, Blachnio-Zabielska A, Turban S, Loiseau N, Lipina C, Stretton C, Bourron O, Ferré P, Foufelle F, Hundal HS, Hajduch E.

PLoS One. 2014 Jul 24;9(7):e101865. doi: 10.1371/journal.pone.0101865. eCollection 2014.


Proteomic analysis reveals cellular pathways regulating carbohydrate metabolism that are modulated in primary human skeletal muscle culture due to treatment with bioactives from Artemisia dracunculus L.

Scherp P, Putluri N, LeBlanc GJ, Wang ZQ, Zhang XH, Yu Y, Ribnicky D, Cefalu WT, Kheterpal I.

J Proteomics. 2012 Jun 18;75(11):3199-210. doi: 10.1016/j.jprot.2012.03.024. Epub 2012 Mar 26.


An ethanolic extract of Artemisia dracunculus L. regulates gene expression of ubiquitin-proteasome system enzymes in skeletal muscle: potential role in the treatment of sarcopenic obesity.

Kirk-Ballard H, Kilroy G, Day BC, Wang ZQ, Ribnicky DM, Cefalu WT, Floyd ZE.

Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S21-5. doi: 10.1016/j.nut.2014.02.027. Epub 2014 Mar 14.


Artemisia dracunculus L. polyphenols complexed to soy protein show enhanced bioavailability and hypoglycemic activity in C57BL/6 mice.

Ribnicky DM, Roopchand DE, Poulev A, Kuhn P, Oren A, Cefalu WT, Raskin I.

Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S4-10. doi: 10.1016/j.nut.2014.03.009. Epub 2014 Mar 28.


Stinging Nettle (Urtica dioica L.) Attenuates FFA Induced Ceramide Accumulation in 3T3-L1 Adipocytes in an Adiponectin Dependent Manner.

Obanda DN, Zhao P, Richard AJ, Ribnicky D, Cefalu WT, Stephens JM.

PLoS One. 2016 Mar 3;11(3):e0150252. doi: 10.1371/journal.pone.0150252. eCollection 2016.


Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance.

Boon J, Hoy AJ, Stark R, Brown RD, Meex RC, Henstridge DC, Schenk S, Meikle PJ, Horowitz JF, Kingwell BA, Bruce CR, Watt MJ.

Diabetes. 2013 Feb;62(2):401-10. doi: 10.2337/db12-0686. Epub 2012 Nov 8.


Oral administration of a PPAR-delta agonist to rodents worsens, not improves, maximal insulin-stimulated glucose transport in skeletal muscle of different fibers.

Cresser J, Bonen A, Chabowski A, Stefanyk LE, Gulli R, Ritchie I, Dyck DJ.

Am J Physiol Regul Integr Comp Physiol. 2010 Aug;299(2):R470-9. doi: 10.1152/ajpregu.00431.2009. Epub 2010 Jun 10.


Ceramide-activated protein phosphatase involvement in insulin resistance via Akt, serine/arginine-rich protein 40, and ribonucleic acid splicing in L6 skeletal muscle cells.

Ghosh N, Patel N, Jiang K, Watson JE, Cheng J, Chalfant CE, Cooper DR.

Endocrinology. 2007 Mar;148(3):1359-66. Epub 2006 Dec 7.


Regulation of insulin action by an extract of Artemisia dracunculus L. in primary human skeletal muscle culture: a proteomics approach.

Kheterpal I, Coleman L, Ku G, Wang ZQ, Ribnicky D, Cefalu WT.

Phytother Res. 2010 Sep;24(9):1278-84. doi: 10.1002/ptr.3093.


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