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Items: 1 to 20 of 295

1.

CREPT/RPRD1B, a recently identified novel protein highly expressed in tumors, enhances the β-catenin·TCF4 transcriptional activity in response to Wnt signaling.

Zhang Y, Liu C, Duan X, Ren F, Li S, Jin Z, Wang Y, Feng Y, Liu Z, Chang Z.

J Biol Chem. 2014 Aug 15;289(33):22589-99. doi: 10.1074/jbc.M114.560979. Epub 2014 Jun 30.

2.

p15RS attenuates Wnt/{beta}-catenin signaling by disrupting {beta}-catenin·TCF4 Interaction.

Wu Y, Zhang Y, Zhang H, Yang X, Wang Y, Ren F, Liu H, Zhai Y, Jia B, Yu J, Chang Z.

J Biol Chem. 2010 Nov 5;285(45):34621-31. doi: 10.1074/jbc.M110.148791. Epub 2010 Aug 25.

3.

p15RS/RPRD1A (p15INK4b-related sequence/regulation of nuclear pre-mRNA domain-containing protein 1A) interacts with HDAC2 in inhibition of the Wnt/β-catenin signaling pathway.

Liu C, Zhang Y, Li J, Wang Y, Ren F, Zhou Y, Wu Y, Feng Y, Zhou Y, Su F, Jia B, Wang D, Chang Z.

J Biol Chem. 2015 Apr 10;290(15):9701-13. doi: 10.1074/jbc.M114.620872. Epub 2015 Feb 19.

4.

Human telomerase reverse transcriptase (hTERT) is a novel target of the Wnt/β-catenin pathway in human cancer.

Zhang Y, Toh L, Lau P, Wang X.

J Biol Chem. 2012 Sep 21;287(39):32494-511. Epub 2012 Jul 31.

5.

Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4).

Togi S, Ikeda O, Kamitani S, Nakasuji M, Sekine Y, Muromoto R, Nanbo A, Oritani K, Kawai T, Akira S, Matsuda T.

J Biol Chem. 2011 May 27;286(21):19170-7. doi: 10.1074/jbc.M110.189829. Epub 2011 Mar 30.

6.

Transcription factor Zic2 inhibits Wnt/β-catenin protein signaling.

Pourebrahim R, Houtmeyers R, Ghogomu S, Janssens S, Thelie A, Tran HT, Langenberg T, Vleminckx K, Bellefroid E, Cassiman JJ, Tejpar S.

J Biol Chem. 2011 Oct 28;286(43):37732-40. doi: 10.1074/jbc.M111.242826. Epub 2011 Sep 9.

7.

ITF2 prevents activation of the β-catenin-TCF4 complex in colon cancer cells and levels decrease with tumor progression.

Shin HW, Choi H, So D, Kim YI, Cho K, Chung HJ, Lee KH, Chun YS, Cho CH, Kang GH, Kim WH, Park JW.

Gastroenterology. 2014 Aug;147(2):430-442.e8. doi: 10.1053/j.gastro.2014.04.047. Epub 2014 May 15.

PMID:
24846398
8.

Human SMC2 protein, a core subunit of human condensin complex, is a novel transcriptional target of the WNT signaling pathway and a new therapeutic target.

Dávalos V, Súarez-López L, Castaño J, Messent A, Abasolo I, Fernandez Y, Guerra-Moreno A, Espín E, Armengol M, Musulen E, Ariza A, Sayós J, Arango D, Schwartz S Jr.

J Biol Chem. 2012 Dec 21;287(52):43472-81. doi: 10.1074/jbc.M112.428466. Epub 2012 Oct 24.

9.

SOX9 regulates low density lipoprotein receptor-related protein 6 (LRP6) and T-cell factor 4 (TCF4) expression and Wnt/β-catenin activation in breast cancer.

Wang H, He L, Ma F, Regan MM, Balk SP, Richardson AL, Yuan X.

J Biol Chem. 2013 Mar 1;288(9):6478-87. doi: 10.1074/jbc.M112.419184. Epub 2013 Jan 10.

10.

Context-dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cancer cells.

Ju X, Ishikawa TO, Naka K, Ito K, Ito Y, Oshima M.

Cancer Sci. 2014 Apr;105(4):418-24. doi: 10.1111/cas.12356. Epub 2014 Feb 18.

11.

ZEB1 and TCF4 reciprocally modulate their transcriptional activities to regulate Wnt target gene expression.

Sánchez-Tilló E, de Barrios O, Valls E, Darling DS, Castells A, Postigo A.

Oncogene. 2015 Nov 12;34(46):5760-70. doi: 10.1038/onc.2015.352. Epub 2015 Sep 21.

PMID:
26387539
12.

Activation of the Wnt/β-catenin pathway represses the transcription of the β-amyloid precursor protein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter.

Parr C, Mirzaei N, Christian M, Sastre M.

FASEB J. 2015 Feb;29(2):623-35. doi: 10.1096/fj.14-253211. Epub 2014 Nov 10.

PMID:
25384422
13.

MENA is a transcriptional target of the Wnt/beta-catenin pathway.

Najafov A, Seker T, Even I, Hoxhaj G, Selvi O, Ozel DE, Koman A, Birgül-İyison N.

PLoS One. 2012;7(5):e37013. doi: 10.1371/journal.pone.0037013. Epub 2012 May 17.

14.

Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis.

Jiang L, Yin M, Wei X, Liu J, Wang X, Niu C, Kang X, Xu J, Zhou Z, Sun S, Wang X, Zheng X, Duan S, Yao K, Qian R, Sun N, Chen A, Wang R, Zhang J, Chen S, Meng D.

Circ Res. 2015 Jul 31;117(4):364-375. doi: 10.1161/CIRCRESAHA.115.306829. Epub 2015 Jun 29. Erratum in: Circ Res. 2015 Oct 9;117(9):e79.

15.

The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane.

Loregger A, Grandl M, Mejías-Luque R, Allgäuer M, Degenhart K, Haselmann V, Oikonomou C, Hatzis P, Janssen KP, Nitsche U, Gradl D, van den Broek O, Destree O, Ulm K, Neumaier M, Kalali B, Jung A, Varela I, Schmid RM, Rad R, Busch DH, Gerhard M.

Sci Signal. 2015 Sep 8;8(393):ra90. doi: 10.1126/scisignal.aac6757.

PMID:
26350900
16.

Henryin, an ent-kaurane diterpenoid, inhibits Wnt signaling through interference with β-catenin/TCF4 interaction in colorectal cancer cells.

Li X, Pu J, Jiang S, Su J, Kong L, Mao B, Sun H, Li Y.

PLoS One. 2013 Jul 2;8(7):e68525. doi: 10.1371/journal.pone.0068525. Print 2013.

17.

OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors.

Ye GD, Sun GB, Jiao P, Chen C, Liu QF, Huang XL, Zhang R, Cai WY, Li SN, Wu JF, Liu YJ, Wu RS, Xie YY, Chan EC, Liou YC, Li BA.

Gastroenterology. 2016 Mar;150(3):659-671.e16. doi: 10.1053/j.gastro.2015.11.041. Epub 2015 Nov 24.

PMID:
26619963
18.

Wnt/β-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells.

Konsavage WM Jr, Kyler SL, Rennoll SA, Jin G, Yochum GS.

J Biol Chem. 2012 Apr 6;287(15):11730-9. doi: 10.1074/jbc.M111.327767. Epub 2012 Feb 15.

19.

The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis.

Mahmoudi T, Boj SF, Hatzis P, Li VS, Taouatas N, Vries RG, Teunissen H, Begthel H, Korving J, Mohammed S, Heck AJ, Clevers H.

PLoS Biol. 2010 Nov 16;8(11):e1000539. doi: 10.1371/journal.pbio.1000539. Erratum in: PLoS Biol. 2017 Feb 7;15(2):e1002596.

20.

β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness.

Sánchez-Tilló E, de Barrios O, Siles L, Cuatrecasas M, Castells A, Postigo A.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19204-9. doi: 10.1073/pnas.1108977108. Epub 2011 Nov 11.

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