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Retracted: Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate lyase signaling.

Gao Y, Zeng Y, Tian J, Islam MS, Jiang G, Xiao D.

Oncotarget. 2014 Jun 26. pii: 2138. Epub 2014 Jun 26. Retraction in: Oncotarget. 2015 Oct 6;6(30):30420.


Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth.

Gao Y, Islam MS, Tian J, Lui VW, Xiao D.

Cancer Lett. 2014 Jul 10;349(1):15-25. doi: 10.1016/j.canlet.2014.03.015. Epub 2014 Mar 29.


z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo.

Xiao D, Singh SV.

Mol Cancer Ther. 2008 Jan;7(1):171-80. doi: 10.1158/1535-7163.MCT-07-0491.


ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.

Migita T, Narita T, Nomura K, Miyagi E, Inazuka F, Matsuura M, Ushijima M, Mashima T, Seimiya H, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y.

Cancer Res. 2008 Oct 15;68(20):8547-54. doi: 10.1158/0008-5472.CAN-08-1235.


Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact.

Migita T, Okabe S, Ikeda K, Igarashi S, Sugawara S, Tomida A, Taguchi R, Soga T, Seimiya H.

Am J Pathol. 2013 May;182(5):1800-10. doi: 10.1016/j.ajpath.2013.01.048. Epub 2013 Mar 15.


Reactive oxygen species-dependent apoptosis by gugulipid extract of Ayurvedic medicine plant Commiphora mukul in human prostate cancer cells is regulated by c-Jun N-terminal kinase.

Xiao D, Zeng Y, Prakash L, Badmaev V, Majeed M, Singh SV.

Mol Pharmacol. 2011 Mar;79(3):499-507. doi: 10.1124/mol.110.068551. Epub 2010 Nov 29.


ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway.

Lee JH, Jang H, Lee SM, Lee JE, Choi J, Kim TW, Cho EJ, Youn HD.

FEBS J. 2015 Jan;282(2):361-71. doi: 10.1111/febs.13139. Epub 2014 Nov 23.


ATP citrate lyase knockdown induces growth arrest and apoptosis through different cell- and environment-dependent mechanisms.

Zaidi N, Royaux I, Swinnen JV, Smans K.

Mol Cancer Ther. 2012 Sep;11(9):1925-35. doi: 10.1158/1535-7163.MCT-12-0095. Epub 2012 Jun 20.


Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential.

Xiao D, Lew KL, Zeng Y, Xiao H, Marynowski SW, Dhir R, Singh SV.

Carcinogenesis. 2006 Nov;27(11):2223-34. Epub 2006 Jun 13.


Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway.

Tanaka Y, Gavrielides MV, Mitsuuchi Y, Fujii T, Kazanietz MG.

J Biol Chem. 2003 Sep 5;278(36):33753-62. Epub 2003 Jun 24.


ATP citrate lyase (ACLY): a promising target for cancer prevention and treatment.

Khwairakpam AD, Shyamananda MS, Sailo BL, Rathnakaram SR, Padmavathi G, Kotoky J, Kunnumakkara AB.

Curr Drug Targets. 2015;16(2):156-63. Review.


Shikonin inhibits prostate cancer cells metastasis by reducing matrix metalloproteinase-2/-9 expression via AKT/mTOR and ROS/ERK1/2 pathways.

Chen Y, Zheng L, Liu J, Zhou Z, Cao X, Lv X, Chen F.

Int Immunopharmacol. 2014 Aug;21(2):447-55. doi: 10.1016/j.intimp.2014.05.026. Epub 2014 Jun 3.


miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.

Xin M, Qiao Z, Li J, Liu J, Song S, Zhao X, Miao P, Tang T, Wang L, Liu W, Yang X, Dai K, Huang G.

Oncotarget. 2016 Jul 12;7(28):44252-44265. doi: 10.18632/oncotarget.10020.


Honokiol, a constituent of oriental medicinal herb magnolia officinalis, inhibits growth of PC-3 xenografts in vivo in association with apoptosis induction.

Hahm ER, Arlotti JA, Marynowski SW, Singh SV.

Clin Cancer Res. 2008 Feb 15;14(4):1248-57. doi: 10.1158/1078-0432.CCR-07-1926.


Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells by independently targeting pro-survival Akt and mTOR.

Deeb D, Gao X, Jiang H, Dulchavsky SA, Gautam SC.

Prostate. 2009 Jun 1;69(8):851-60. doi: 10.1002/pros.20937.


Decreased Warburg effect induced by ATP citrate lyase suppression inhibits tumor growth in pancreatic cancer.

Zong H, Zhang Y, You Y, Cai T, Wang Y.

Med Oncol. 2015 Mar;32(3):85. doi: 10.1007/s12032-015-0540-z. Epub 2015 Feb 21. Retraction in: Med Oncol. 2015 Oct;32(10):243.


Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.

Kaur P, Shukla S, Gupta S.

Carcinogenesis. 2008 Nov;29(11):2210-7. doi: 10.1093/carcin/bgn201. Epub 2008 Aug 25.

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