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Items: 1 to 20 of 115

1.

Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells.

Ertych N, Stolz A, Stenzinger A, Weichert W, Kaulfuß S, Burfeind P, Aigner A, Wordeman L, Bastians H.

Nat Cell Biol. 2014 Aug;16(8):779-91. doi: 10.1038/ncb2994. Epub 2014 Jun 29.

2.

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

Ertych N, Stolz A, Valerius O, Braus GH, Bastians H.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1817-22. doi: 10.1073/pnas.1525129113. Epub 2016 Feb 1.

3.

A growing role for Aurora A in chromosome instability.

Maia AR, van Heesbeen RG, Medema RH.

Nat Cell Biol. 2014 Aug;16(8):739-41. doi: 10.1038/ncb3018.

PMID:
25082197
4.

The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells.

Stolz A, Ertych N, Kienitz A, Vogel C, Schneider V, Fritz B, Jacob R, Dittmar G, Weichert W, Petersen I, Bastians H.

Nat Cell Biol. 2010 May;12(5):492-9. doi: 10.1038/ncb2051. Epub 2010 Apr 4.

PMID:
20364141
5.

The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability.

Lüddecke S, Ertych N, Stenzinger A, Weichert W, Beissbarth T, Dyczkowski J, Gaedcke J, Valerius O, Braus GH, Kschischo M, Bastians H.

Oncogene. 2016 May 5;35(18):2398-406. doi: 10.1038/onc.2015.290. Epub 2015 Aug 24.

PMID:
26300001
6.

Examining the link between chromosomal instability and aneuploidy in human cells.

Thompson SL, Compton DA.

J Cell Biol. 2008 Feb 25;180(4):665-72. doi: 10.1083/jcb.200712029. Epub 2008 Feb 18.

7.

A phenotypic screen identifies microtubule plus end assembly regulators that can function in mitotic spindle orientation.

Stolz A, Ertych N, Bastians H.

Cell Cycle. 2015;14(6):827-37. doi: 10.1080/15384101.2014.1000693.

8.

DNA-damage response during mitosis induces whole-chromosome missegregation.

Bakhoum SF, Kabeche L, Murnane JP, Zaki BI, Compton DA.

Cancer Discov. 2014 Nov;4(11):1281-9. doi: 10.1158/2159-8290.CD-14-0403. Epub 2014 Aug 8.

9.

Mechanisms of chromosomal instability.

Thompson SL, Bakhoum SF, Compton DA.

Curr Biol. 2010 Mar 23;20(6):R285-95. doi: 10.1016/j.cub.2010.01.034. Review.

11.

Chromosomal instability, colorectal cancer and taxane resistance.

Swanton C, Tomlinson I, Downward J.

Cell Cycle. 2006 Apr;5(8):818-23. Epub 2006 Apr 17. Review.

PMID:
16628000
13.

Loss of the tumour-suppressor genes CHK2 and BRCA1 results in chromosomal instability.

Stolz A, Ertych N, Bastians H.

Biochem Soc Trans. 2010 Dec;38(6):1704-8. doi: 10.1042/BST0381704.

PMID:
21118151
14.

Aurora-A expression is independently associated with chromosomal instability in colorectal cancer.

Baba Y, Nosho K, Shima K, Irahara N, Kure S, Toyoda S, Kirkner GJ, Goel A, Fuchs CS, Ogino S.

Neoplasia. 2009 May;11(5):418-25.

15.

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.

Sanhaji M, Friel CT, Wordeman L, Louwen F, Yuan J.

Oncotarget. 2011 Dec;2(12):935-47. Review.

16.

Replication stress links structural and numerical cancer chromosomal instability.

Burrell RA, McClelland SE, Endesfelder D, Groth P, Weller MC, Shaikh N, Domingo E, Kanu N, Dewhurst SM, Gronroos E, Chew SK, Rowan AJ, Schenk A, Sheffer M, Howell M, Kschischo M, Behrens A, Helleday T, Bartek J, Tomlinson IP, Swanton C.

Nature. 2013 Feb 28;494(7438):492-496. doi: 10.1038/nature11935. Erratum in: Nature. 2013 Aug 22;500(7463):490.

17.

High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation.

Zasadil LM, Britigan EM, Ryan SD, Kaur C, Guckenberger DJ, Beebe DJ, Moser AR, Weaver BA.

Mol Biol Cell. 2016 Jul 1;27(13):1981-9. doi: 10.1091/mbc.E15-10-0747. Epub 2016 May 4.

18.

APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability.

Sansregret L, Patterson JO, Dewhurst S, López-García C, Koch A, McGranahan N, Chao WCH, Barry DJ, Rowan A, Instrell R, Horswell S, Way M, Howell M, Singleton MR, Medema RH, Nurse P, Petronczki M, Swanton C.

Cancer Discov. 2017 Feb;7(2):218-233. doi: 10.1158/2159-8290.CD-16-0645. Epub 2017 Jan 9.

19.

A mechanism linking extra centrosomes to chromosomal instability.

Ganem NJ, Godinho SA, Pellman D.

Nature. 2009 Jul 9;460(7252):278-82. doi: 10.1038/nature08136. Epub 2009 Jun 7.

20.

Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer.

Iwaizumi M, Shinmura K, Mori H, Yamada H, Suzuki M, Kitayama Y, Igarashi H, Nakamura T, Suzuki H, Watanabe Y, Hishida A, Ikuma M, Sugimura H.

Gut. 2009 Feb;58(2):249-60. doi: 10.1136/gut.2008.149468. Epub 2008 Jul 17.

PMID:
18635744

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