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Increased Nek1 expression in renal cell carcinoma cells is associated with decreased sensitivity to DNA-damaging treatment.

Chen Y, Chen CF, Polci R, Wei R, Riley DJ, Chen PL.

Oncotarget. 2014 Jun 30;5(12):4283-94.


Nek1 regulates cell death and mitochondrial membrane permeability through phosphorylation of VDAC1.

Chen Y, Craigen WJ, Riley DJ.

Cell Cycle. 2009 Jan 15;8(2):257-67. Epub 2009 Jan 4.


Phosphorylation by Nek1 regulates opening and closing of voltage dependent anion channel 1.

Chen Y, Gaczynska M, Osmulski P, Polci R, Riley DJ.

Biochem Biophys Res Commun. 2010 Apr 9;394(3):798-803. doi: 10.1016/j.bbrc.2010.03.077. Epub 2010 Mar 15.


Nek1 silencing slows down DNA repair and blocks DNA damage-induced cell cycle arrest.

Pelegrini AL, Moura DJ, Brenner BL, Ledur PF, Maques GP, Henriques JA, Saffi J, Lenz G.

Mutagenesis. 2010 Sep;25(5):447-54. doi: 10.1093/mutage/geq026. Epub 2010 May 25.


Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.

Chen Y, Chen CF, Riley DJ, Chen PL.

Cell Cycle. 2011 Feb 15;10(4):655-63. Epub 2011 Feb 15.


Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint control.

Chen Y, Chen PL, Chen CF, Jiang X, Riley DJ.

Cell Cycle. 2008 Oct;7(20):3194-201. Epub 2008 Oct 18.


Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.

Liu S, Ho CK, Ouyang J, Zou L.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2175-80. doi: 10.1073/pnas.1217781110. Epub 2013 Jan 23.


Identification of the proteome complement of humanTLK1 reveals it binds and phosphorylates NEK1 regulating its activity.

Singh V, Connelly ZM, Shen X, De Benedetti A.

Cell Cycle. 2017 May 19;16(10):915-926. doi: 10.1080/15384101.2017.1314421. Epub 2017 Apr 20.


Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability.

Chen Y, Chen CF, Chiang HC, Pena M, Polci R, Wei RL, Edwards RA, Hansel DE, Chen PL, Riley DJ.

Mol Cancer. 2011 Jan 10;10(1):5. doi: 10.1186/1476-4598-10-5.


NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response.

Polci R, Peng A, Chen PL, Riley DJ, Chen Y.

Cancer Res. 2004 Dec 15;64(24):8800-3.


Nek1 shares structural and functional similarities with NIMA kinase.

Feige E, Shalom O, Tsuriel S, Yissachar N, Motro B.

Biochim Biophys Acta. 2006 Mar;1763(3):272-81. Epub 2006 Feb 21.


Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression.

Patil M, Pabla N, Ding HF, Dong Z.

Cell Cycle. 2013 Aug 15;12(16):2608-16. doi: 10.4161/cc.25624. Epub 2013 Jul 10.


Expression of Nek1 during kidney development and cyst formation in multiple nephron segments in the Nek1-deficient kat2J mouse model of polycystic kidney disease.

Chen Y, Chiang HC, Litchfield P, Pena M, Juang C, Riley DJ.

J Biomed Sci. 2014 Jul 17;21:63. doi: 10.1186/s12929-014-0063-5.


Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization.

Patil M, Pabla N, Huang S, Dong Z.

Cell Cycle. 2013 Jan 1;12(1):166-71. doi: 10.4161/cc.23053. Epub 2012 Dec 19.


The NEK1 interactor, C21ORF2, is required for efficient DNA damage repair.

Fang X, Lin H, Wang X, Zuo Q, Qin J, Zhang P.

Acta Biochim Biophys Sin (Shanghai). 2015 Oct;47(10):834-41. doi: 10.1093/abbs/gmv076. Epub 2015 Aug 18.


The NIMA-related kinase NEK1 cycles through the nucleus.

Hilton LK, White MC, Quarmby LM.

Biochem Biophys Res Commun. 2009 Nov 6;389(1):52-6. doi: 10.1016/j.bbrc.2009.08.086. Epub 2009 Aug 21.


The mammalian Nek1 kinase is involved in primary cilium formation.

Shalom O, Shalva N, Altschuler Y, Motro B.

FEBS Lett. 2008 Apr 30;582(10):1465-70. doi: 10.1016/j.febslet.2008.03.036. Epub 2008 Apr 1.


Harnessing the p53-PUMA axis to overcome DNA damage resistance in renal cell carcinoma.

Zhou X, Tolstov Y, Arslan A, Roth W, GrĂ¼llich C, Pahernik S, Hohenfellner M, Duensing S.

Neoplasia. 2014 Dec;16(12):1028-35. doi: 10.1016/j.neo.2014.09.012.


Targeting Integrin-Linked Kinase Suppresses Invasion and Metastasis through Downregulation of Epithelial-to-Mesenchymal Transition in Renal Cell Carcinoma.

Han KS, Li N, Raven PA, Fazli L, Ettinger S, Hong SJ, Gleave ME, So AI.

Mol Cancer Ther. 2015 Apr;14(4):1024-34. doi: 10.1158/1535-7163.MCT-14-0771. Epub 2015 Feb 5.

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