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Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury.

Peng J, Li X, Zhang D, Chen JK, Su Y, Smith SB, Dong Z.

Kidney Int. 2015 Jan;87(1):137-50. doi: 10.1038/ki.2014.226. Epub 2014 Jun 25.


ROS, P53, and ischemic acute kidney injury in diabetic models.

Wen J, Shu Y, Zhang W.

Kidney Int. 2015 Jul;88(1):198-9. doi: 10.1038/ki.2015.130. No abstract available.


DNA damage response in renal ischemia-reperfusion and ATP-depletion injury of renal tubular cells.

Ma Z, Wei Q, Dong G, Huo Y, Dong Z.

Biochim Biophys Acta. 2014 Jul;1842(7):1088-96. doi: 10.1016/j.bbadis.2014.04.002. Epub 2014 Apr 12.


Persistent disruption of mitochondrial homeostasis after acute kidney injury.

Funk JA, Schnellmann RG.

Am J Physiol Renal Physiol. 2012 Apr 1;302(7):F853-64. doi: 10.1152/ajprenal.00035.2011. Epub 2011 Dec 7.


p53 is renoprotective after ischemic kidney injury by reducing inflammation.

Sutton TA, Hato T, Mai E, Yoshimoto M, Kuehl S, Anderson M, Mang H, Plotkin Z, Chan RJ, Dagher PC.

J Am Soc Nephrol. 2013 Jan;24(1):113-24. doi: 10.1681/ASN.2012050469. Epub 2012 Dec 6.


The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury.

Dagher PC, Mai EM, Hato T, Lee SY, Anderson MD, Karozos SC, Mang HE, Knipe NL, Plotkin Z, Sutton TA.

Am J Physiol Renal Physiol. 2012 Jan 15;302(2):F284-91. doi: 10.1152/ajprenal.00317.2011. Epub 2011 Nov 2.


Tubular p53 regulates multiple genes to mediate AKI.

Zhang D, Liu Y, Wei Q, Huo Y, Liu K, Liu F, Dong Z.

J Am Soc Nephrol. 2014 Oct;25(10):2278-89. doi: 10.1681/ASN.2013080902. Epub 2014 Apr 3.


OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury.

Xiao X, Hu Y, Quirós PM, Wei Q, López-Otín C, Dong Z.

Am J Physiol Renal Physiol. 2014 Jun 1;306(11):F1318-26. doi: 10.1152/ajprenal.00036.2014. Epub 2014 Mar 26.


Do tubular changes in the diabetic kidney affect the susceptibility to acute kidney injury?

Vallon V.

Nephron Clin Pract. 2014;127(1-4):133-8. doi: 10.1159/000363554. Epub 2014 Sep 24. Review.


The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury.

Fan H, Yang HC, You L, Wang YY, He WJ, Hao CM.

Kidney Int. 2013 Mar;83(3):404-13. doi: 10.1038/ki.2012.394. Epub 2013 Jan 9.


The Authors Reply.

Dong Z.

Kidney Int. 2015 Jul;88(1):199. doi: 10.1038/ki.2015.131. No abstract available.


Acute kidney injury after hepatic ischemia and reperfusion injury in mice.

Lee HT, Park SW, Kim M, D'Agati VD.

Lab Invest. 2009 Feb;89(2):196-208. doi: 10.1038/labinvest.2008.124. Epub 2008 Dec 15.


TNFR1-dependent pulmonary apoptosis during ischemic acute kidney injury.

White LE, Santora RJ, Cui Y, Moore FA, Hassoun HT.

Am J Physiol Lung Cell Mol Physiol. 2012 Sep;303(5):L449-59. doi: 10.1152/ajplung.00301.2011. Epub 2012 Jun 22.


Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis.

Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H.

Am J Physiol Renal Physiol. 2009 Jul;297(1):F125-37. doi: 10.1152/ajprenal.90666.2008. Epub 2009 Apr 29.


TNF-α mediates increased susceptibility to ischemic AKI in diabetes.

Gao G, Zhang B, Ramesh G, Betterly D, Tadagavadi RK, Wang W, Reeves WB.

Am J Physiol Renal Physiol. 2013 Mar 1;304(5):F515-21. doi: 10.1152/ajprenal.00533.2012. Epub 2013 Jan 2.


Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule-specific knockout mouse models.

Wei Q, Dong G, Chen JK, Ramesh G, Dong Z.

Kidney Int. 2013 Jul;84(1):138-48. doi: 10.1038/ki.2013.68. Epub 2013 Mar 6.


UNC5B receptor deletion exacerbates tissue injury in response to AKI.

Ranganathan P, Jayakumar C, Navankasattusas S, Li DY, Kim IM, Ramesh G.

J Am Soc Nephrol. 2014 Feb;25(2):239-49. doi: 10.1681/ASN.2013040418. Epub 2013 Oct 10.


Disruption of renal tubular mitochondrial quality control by Myo-inositol oxygenase in diabetic kidney disease.

Zhan M, Usman IM, Sun L, Kanwar YS.

J Am Soc Nephrol. 2015 Jun;26(6):1304-21. doi: 10.1681/ASN.2014050457. Epub 2014 Sep 30.


Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice.

Zhou D, Li Y, Lin L, Zhou L, Igarashi P, Liu Y.

Kidney Int. 2012 Sep;82(5):537-47. doi: 10.1038/ki.2012.173. Epub 2012 May 23. Erratum in: Kidney Int. 2013 Sep;84(3):626.


Autophagy in proximal tubules protects against acute kidney injury.

Jiang M, Wei Q, Dong G, Komatsu M, Su Y, Dong Z.

Kidney Int. 2012 Dec;82(12):1271-83. doi: 10.1038/ki.2012.261. Epub 2012 Aug 1.

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