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CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase.

Shibata E, Dar A, Dutta A.

J Biol Chem. 2014 Aug 15;289(33):23056-64. doi: 10.1074/jbc.M114.574210. Epub 2014 Jun 24.


Thymine DNA glycosylase is a CRL4Cdt2 substrate.

Slenn TJ, Morris B, Havens CG, Freeman RM Jr, Takahashi TS, Walter JC.

J Biol Chem. 2014 Aug 15;289(33):23043-55. doi: 10.1074/jbc.M114.574194. Epub 2014 Jun 19.


CDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis.

Rizzardi LF, Coleman KE, Varma D, Matson JP, Oh S, Cook JG.

J Biol Chem. 2015 Jan 2;290(1):556-67. doi: 10.1074/jbc.M114.614701. Epub 2014 Nov 19.


Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV irradiation.

Shiomi Y, Hayashi A, Ishii T, Shinmyozu K, Nakayama J, Sugasawa K, Nishitani H.

Mol Cell Biol. 2012 Jun;32(12):2279-88. doi: 10.1128/MCB.06506-11. Epub 2012 Apr 9.


Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2.

Havens CG, Walter JC.

Mol Cell. 2009 Jul 10;35(1):93-104. doi: 10.1016/j.molcel.2009.05.012.


PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A.

Genes Dev. 2008 Sep 15;22(18):2496-506. doi: 10.1101/gad.1676108.


CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis.

Terai K, Abbas T, Jazaeri AA, Dutta A.

Mol Cell. 2010 Jan 15;37(1):143-9. doi: 10.1016/j.molcel.2009.12.018.


Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2.

Havens CG, Shobnam N, Guarino E, Centore RC, Zou L, Kearsey SE, Walter JC.

J Biol Chem. 2012 Mar 30;287(14):11410-21. doi: 10.1074/jbc.M111.337683. Epub 2012 Feb 2.


Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.

Shibata E, Abbas T, Huang X, Wohlschlegel JA, Dutta A.

Mol Cell Biol. 2011 Aug;31(15):3136-45. doi: 10.1128/MCB.05496-11. Epub 2011 May 31.


PCNA-dependent ubiquitination of Cdt1 and p21 in mammalian cells.

Hayashi A, Suenaga N, Shiomi Y, Nishitani H.

Methods Mol Biol. 2014;1170:367-82. doi: 10.1007/978-1-4939-0888-2_19.


Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4(Cdt2) -mediated proteolysis.

Michishita M, Morimoto A, Ishii T, Komori H, Shiomi Y, Higuchi Y, Nishitani H.

Genes Cells. 2011 Jan;16(1):12-22. doi: 10.1111/j.1365-2443.2010.01464.x. Epub 2010 Dec 9.


The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA.

Kim DH, Budhavarapu VN, Herrera CR, Nam HW, Kim YS, Yew PR.

Mol Cell Biol. 2010 Sep;30(17):4120-33. doi: 10.1128/MCB.01135-09. Epub 2010 Jul 6.


PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage.

Tsanov N, Kermi C, Coulombe P, Van der Laan S, Hodroj D, Maiorano D.

Nucleic Acids Res. 2014 Apr;42(6):3692-706. doi: 10.1093/nar/gkt1400. Epub 2014 Jan 14.


Sequential replication-coupled destruction at G1/S ensures genome stability.

Coleman KE, Grant GD, Haggerty RA, Brantley K, Shibata E, Workman BD, Dutta A, Varma D, Purvis JE, Cook JG.

Genes Dev. 2015 Aug 15;29(16):1734-46. doi: 10.1101/gad.263731.115. Epub 2015 Aug 13.


Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells.

Ishii T, Shiomi Y, Takami T, Murakami Y, Ohnishi N, Nishitani H.

J Biol Chem. 2010 Dec 31;285(53):41993-2000. doi: 10.1074/jbc.M110.161661. Epub 2010 Oct 7.


CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.

Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L.

Mol Cell. 2010 Oct 8;40(1):22-33. doi: 10.1016/j.molcel.2010.09.015.


SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation.

Jørgensen S, Eskildsen M, Fugger K, Hansen L, Larsen MS, Kousholt AN, Syljuåsen RG, Trelle MB, Jensen ON, Helin K, Sørensen CS.

J Cell Biol. 2011 Jan 10;192(1):43-54. doi: 10.1083/jcb.201009076.


Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.

Lee HO, Zacharek SJ, Xiong Y, Duronio RJ.

Mol Biol Cell. 2010 Nov 1;21(21):3639-53. doi: 10.1091/mbc.E10-02-0130. Epub 2010 Sep 8.


A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase.

Zhang S, Zhao H, Darzynkiewicz Z, Zhou P, Zhang Z, Lee EY, Lee MY.

J Biol Chem. 2013 Oct 11;288(41):29550-61. doi: 10.1074/jbc.M113.490466. Epub 2013 Aug 2.


Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase.

Havens CG, Walter JC.

Genes Dev. 2011 Aug 1;25(15):1568-82. doi: 10.1101/gad.2068611. Review.

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