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Items: 1 to 20 of 100

1.

Akt enhances Runx2 protein stability by regulating Smurf2 function during osteoblast differentiation.

Choi YH, Kim YJ, Jeong HM, Jin YH, Yeo CY, Lee KY.

FEBS J. 2014 Aug;281(16):3656-66. doi: 10.1111/febs.12887. Epub 2014 Jul 15.

2.

Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.

Kaneki H, Guo R, Chen D, Yao Z, Schwarz EM, Zhang YE, Boyce BF, Xing L.

J Biol Chem. 2006 Feb 17;281(7):4326-33. Epub 2005 Dec 22.

3.

Prolyl isomerase Pin1 enhances osteoblast differentiation through Runx2 regulation.

Lee SH, Choi YH, Kim YJ, Choi HS, Yeo CY, Lee KY.

FEBS Lett. 2013 Nov 15;587(22):3640-7. doi: 10.1016/j.febslet.2013.09.040. Epub 2013 Oct 7.

4.

E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation.

Kumar Y, Kapoor I, Khan K, Thacker G, Khan MP, Shukla N, Kanaujiya JK, Sanyal S, Chattopadhyay N, Trivedi AK.

J Biol Chem. 2015 Dec 25;290(52):30975-87. doi: 10.1074/jbc.M115.669531. Epub 2015 Nov 5.

5.

CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation.

Li X, Huang M, Zheng H, Wang Y, Ren F, Shang Y, Zhai Y, Irwin DM, Shi Y, Chen D, Chang Z.

J Cell Biol. 2008 Jun 16;181(6):959-72. doi: 10.1083/jcb.200711044. Epub 2008 Jun 9.

6.

[Mechanism of transcriptional regulation by Runx2 in osteoblasts].

Komori T.

Clin Calcium. 2006 May;16(5):801-7. Review. Japanese.

PMID:
16679622
7.

Smurf2 regulates the degradation of YY1.

Jeong HM, Lee SH, Yum J, Yeo CY, Lee KY.

Biochim Biophys Acta. 2014 Sep;1843(9):2005-11. doi: 10.1016/j.bbamcr.2014.04.023. Epub 2014 May 4.

8.

BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity.

Jun JH, Yoon WJ, Seo SB, Woo KM, Kim GS, Ryoo HM, Baek JH.

J Biol Chem. 2010 Nov 19;285(47):36410-9. doi: 10.1074/jbc.M110.142307. Epub 2010 Sep 17.

9.

The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation.

Zhu W, He X, Hua Y, Li Q, Wang J, Gan X.

J Biol Chem. 2017 Jul 7;292(27):11178-11188. doi: 10.1074/jbc.M116.772277. Epub 2017 May 12.

PMID:
28500134
10.

Akt phosphorylates and regulates the osteogenic activity of Osterix.

Choi YH, Jeong HM, Jin YH, Li H, Yeo CY, Lee KY.

Biochem Biophys Res Commun. 2011 Aug 5;411(3):637-41. doi: 10.1016/j.bbrc.2011.07.009. Epub 2011 Jul 12.

PMID:
21777568
11.

Promotion of osteoblast differentiation in mesenchymal cells through Cbl-mediated control of STAT5 activity.

Dieudonne FX, Sévère N, Biosse-Duplan M, Weng JJ, Su Y, Marie PJ.

Stem Cells. 2013 Jul;31(7):1340-9. doi: 10.1002/stem.1380.

12.

BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation.

Matsubara T, Kida K, Yamaguchi A, Hata K, Ichida F, Meguro H, Aburatani H, Nishimura R, Yoneda T.

J Biol Chem. 2008 Oct 24;283(43):29119-25. doi: 10.1074/jbc.M801774200. Epub 2008 Aug 14.

13.

Tumor necrosis factor-α enhances the transcription of Smad ubiquitination regulatory factor 1 in an activating protein-1- and Runx2-dependent manner.

Lee HL, Yi T, Baek K, Kwon A, Hwang HR, Qadir AS, Park HJ, Woo KM, Ryoo HM, Kim GS, Baek JH.

J Cell Physiol. 2013 May;228(5):1076-86. doi: 10.1002/jcp.24256.

PMID:
23042144
14.

Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation.

Shen R, Chen M, Wang YJ, Kaneki H, Xing L, O'keefe RJ, Chen D.

J Biol Chem. 2006 Feb 10;281(6):3569-76. Epub 2005 Nov 18.

15.

BMP signaling is required for RUNX2-dependent induction of the osteoblast phenotype.

Phimphilai M, Zhao Z, Boules H, Roca H, Franceschi RT.

J Bone Miner Res. 2006 Apr;21(4):637-46. Epub 2006 Apr 5.

16.

Smurf1 plays a role in EGF inhibition of BMP2-induced osteogenic differentiation.

Lee HL, Park HJ, Kwon A, Baek K, Woo KM, Ryoo HM, Kim GS, Baek JH.

Exp Cell Res. 2014 May 1;323(2):276-87. doi: 10.1016/j.yexcr.2014.03.004. Epub 2014 Mar 11.

PMID:
24631292
17.

KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation.

Shukla S, Allam US, Ahsan A, Chen G, Krishnamurthy PM, Marsh K, Rumschlag M, Shankar S, Whitehead C, Schipper M, Basrur V, Southworth DR, Chinnaiyan AM, Rehemtulla A, Beer DG, Lawrence TS, Nyati MK, Ray D.

Neoplasia. 2014 Feb;16(2):115-28. doi: 10.1593/neo.14184.

18.

YY1 represses the transcriptional activity of Runx2 in C2C12 cells.

Jeong HM, Choi YH, Lee SH, Lee KY.

Mol Cell Endocrinol. 2014 Mar 5;383(1-2):103-10. doi: 10.1016/j.mce.2013.12.001. Epub 2013 Dec 8.

PMID:
24325869
19.

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2.

Sowa H, Kaji H, Hendy GN, Canaff L, Komori T, Sugimoto T, Chihara K.

J Biol Chem. 2004 Sep 24;279(39):40267-75. Epub 2004 May 18.

20.

Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins.

Guo R, Yamashita M, Zhang Q, Zhou Q, Chen D, Reynolds DG, Awad HA, Yanoso L, Zhao L, Schwarz EM, Zhang YE, Boyce BF, Xing L.

J Biol Chem. 2008 Aug 22;283(34):23084-92. doi: 10.1074/jbc.M709848200. Epub 2008 Jun 19.

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