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Constitutive IRF8 expression inhibits AML by activation of repressed immune response signaling.

Sharma A, Yun H, Jyotsana N, Chaturvedi A, Schwarzer A, Yung E, Lai CK, Kuchenbauer F, Argiropoulos B, Görlich K, Ganser A, Humphries RK, Heuser M.

Leukemia. 2015 Jan;29(1):157-68. doi: 10.1038/leu.2014.162. Epub 2014 May 20.


MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.

Heuser M, Argiropoulos B, Kuchenbauer F, Yung E, Piper J, Fung S, Schlenk RF, Dohner K, Hinrichsen T, Rudolph C, Schambach A, Baum C, Schlegelberger B, Dohner H, Ganser A, Humphries RK.

Blood. 2007 Sep 1;110(5):1639-47. Epub 2007 May 9.


Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex.

Heuser M, Yun H, Berg T, Yung E, Argiropoulos B, Kuchenbauer F, Park G, Hamwi I, Palmqvist L, Lai CK, Leung M, Lin G, Chaturvedi A, Thakur BK, Iwasaki M, Bilenky M, Thiessen N, Robertson G, Hirst M, Kent D, Wilson NK, Göttgens B, Eaves C, Cleary ML, Marra M, Ganser A, Humphries RK.

Cancer Cell. 2011 Jul 12;20(1):39-52. doi: 10.1016/j.ccr.2011.06.020.


High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics.

Heuser M, Beutel G, Krauter J, Döhner K, von Neuhoff N, Schlegelberger B, Ganser A.

Blood. 2006 Dec 1;108(12):3898-905. Epub 2006 Aug 15.


MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression.

Meester-Smoor MA, Janssen MJ, Grosveld GC, de Klein A, van IJcken WF, Douben H, Zwarthoff EC.

Carcinogenesis. 2008 Oct;29(10):2025-34. doi: 10.1093/carcin/bgn168. Epub 2008 Jul 16.


Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study.

Langer C, Marcucci G, Holland KB, Radmacher MD, Maharry K, Paschka P, Whitman SP, Mrózek K, Baldus CD, Vij R, Powell BL, Carroll AJ, Kolitz JE, Caligiuri MA, Larson RA, Bloomfield CD.

J Clin Oncol. 2009 Jul 1;27(19):3198-204. doi: 10.1200/JCO.2008.20.6110. Epub 2009 May 18.


Meis2 as a critical player in MN1-induced leukemia.

Lai CK, Norddahl GL, Maetzig T, Rosten P, Lohr T, Sanchez Milde L, von Krosigk N, Docking TR, Heuser M, Karsan A, Humphries RK.

Blood Cancer J. 2017 Sep 29;7(9):e613. doi: 10.1038/bcj.2017.86.


Overexpression of MN1 confers resistance to chemotherapy, accelerates leukemia onset, and suppresses p53 and Bim induction.

Pardee TS.

PLoS One. 2012;7(8):e43185. doi: 10.1371/journal.pone.0043185. Epub 2012 Aug 14.


The interferon consensus sequence binding protein (ICSBP/IRF8) activates transcription of the FANCF gene during myeloid differentiation.

Saberwal G, Horvath E, Hu L, Zhu C, Hjort E, Eklund EA.

J Biol Chem. 2009 Nov 27;284(48):33242-54. doi: 10.1074/jbc.M109.010231. Epub 2009 Oct 2.


Mapping of MN1 sequences necessary for myeloid transformation.

Kandilci A, Surtel J, Janke L, Neale G, Terranova S, Grosveld GC.

PLoS One. 2013 Apr 23;8(4):e61706. doi: 10.1371/journal.pone.0061706. Print 2013.


[Advance of study on MN1 gene in acute myeloid leukemia - review].

Sun HM, Qian SX, Li JY.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Apr;17(2):504-8. Review. Chinese.


Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation.

Kandilci A, Grosveld GC.

Blood. 2009 Aug 20;114(8):1596-606. doi: 10.1182/blood-2009-02-205443. Epub 2009 Jun 26.


Meningioma 1 (MN1) expression: refined risk stratification in acute myeloid leukemia with normal cytogenetics (CN-AML).

Aref S, Ibrahim L, Morkes H, Azmy E, Ebrahim M.

Hematology. 2013 Sep;18(5):277-83. doi: 10.1179/1607845412Y.0000000065. Epub 2013 Jan 25.


Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3.

Argiropoulos B, Yung E, Xiang P, Lo CY, Kuchenbauer F, Palmqvist L, Reindl C, Heuser M, Sekulovic S, Rosten P, Muranyi A, Goh SL, Featherstone M, Humphries RK.

Blood. 2010 May 20;115(20):4071-82. doi: 10.1182/blood-2009-06-225573. Epub 2010 Mar 17.


The clinical characteristics and prognostic significance of MN1 gene and MN1-associated microRNA expression in adult patients with de novo acute myeloid leukemia.

Xiang L, Li M, Liu Y, Cen J, Chen Z, Zhen X, Xie X, Cao X, Gu W.

Ann Hematol. 2013 Aug;92(8):1063-9. doi: 10.1007/s00277-013-1729-x. Epub 2013 Mar 21.


Wilms' tumor gene 1 protein represses the expression of the tumor suppressor interferon regulatory factor 8 in human hematopoietic progenitors and in leukemic cells.

Vidovic K, Svensson E, Nilsson B, Thuresson B, Olofsson T, Lennartsson A, Gullberg U.

Leukemia. 2010 May;24(5):992-1000. doi: 10.1038/leu.2010.33. Epub 2010 Mar 18.


MN1, a novel player in human AML.

Grosveld GC.

Blood Cells Mol Dis. 2007 Nov-Dec;39(3):336-9. Epub 2007 Aug 14. Review.


MN1 and PTEN gene expression in acute myeloid leukemia.

Zayed RA, Eltaweel MA, Botros SK, Zaki MA.

Cancer Biomark. 2017;18(2):177-182. doi: 10.3233/CBM-160235.


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